Discover the powerful story of one woman's lifelong dedication to adventure and determination to succeed, as featured in the brand new BBC2 documentary The Last Mountain 'I shed a tear as I read this . . . I'll admit that I did not do so when I originally heard of her death. The difference? This book' INDEPENDENT ______ Alison Hargeaves was one of the finest climbers of her generation. But in 1995, she died during a violent storm on K2. On her death she was vilified by media outrage that a wife and mother would take such extreme risks. This is the story of a woman with an astonishing determination to be the best that she could. A woman driven to succeed just to secure a future for herself and her family. ______ 'A riveting and incredibly moving story' Irish News 'Few realized the extent of her inner turmoil - and her courage. A very moving biography of an extraordinary woman with an extraordinary talent and determination' Daily Telegraph 'A sensitive and intelligent book . . . Rose and Douglas recuse Hargreaves from the crude distortions of those who wanted to vilify or venerate her' Sunday Telegraph

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

This gripping story belongs with the classics of mountaineering. In 1986, nine expeditions attempted to climb K-2. Twenty-seven climbers reached the summit. Thirteen people died that summer. Two 8-page inserts, one in color. Maps.

A version of the OpenStax text

Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.