This book presents regenerative strategies for the treatment of knee joint disabilities. The book is composed of four main sections totaling 19 chapters which review the current knowledge on the clinical management and preclinical regenerative strategies. It examines the role of different natural-based biomaterials as scaffolds and implants for addressing different tissue lesions in the knee joint. Section one provides an updated and comprehensive discussion on articular cartilage tissue regeneration. Section two focuses on the important contributions for bone and osteochondral tissue engineering. Section three overview the recent advances on meniscus repair/regeneration strategies. Finally, section four further discusses the current strategies for treatment of ligament lesions. Each chapter is prepared by world know expert on their fields, so we do firmly believe that the proposed book will be a reference in the area of biomaterials for regenerative medicine.

This is the 3rd volume in a series of reviews centered on the single major topic of bone replacement, discussing the biology of stem cells and cell signals, the knowledge needed to make stem cell-engineered bone tissue a reality, and how to prevent bone allograft infection. Useful as a followup to its predecessors, and as a stand-alone reference, it will interest a broad audience from orthopedists and bioengineers to dentists.

Advances in Biomedical Polymers and Composites: Materials and Applications is a comprehensive guide to polymers and polymer composites for biomedical applications, bringing together detailed information on their preparation, properties, cutting-edge technologies, innovative materials and key application areas. Sections introduce polymers and composites in biomedical applications and cover characterization techniques, preparation and properties of composites and gel-based systems. Innovative technologies and instruments used in the fabrication of polymer composites for biomedical applications are then presented in detail, including 3D bioprinting, 4D printing, electrospinning, stimuli-responsive polymers and quantum dots. This is a valuable resource for anyone looking to gain a broader understanding of polymers and composites for biomedical applications. In addition, it is ideal for readers who want to conduct interdisciplinary research or explore new avenues for research and development. - Provides broad, systematic and detailed coverage of preparation methods, properties, technologies, structures and applications - Explores the state-of-the-art in biomedical polymers, including gene delivery, oleogels, bigels, 3D bioprinting, 4D printing and antiviral materials - Offers analysis and comparison of experimental data on physical properties and explains environmental, ethical and medical guidelines

Cartilage, Tissue and Knee Joint Biomechanics: Fundamentals, Characterization and Modelling is a cutting-edge multidisciplinary book specifically focused on modeling, characterization and related clinical aspects. The book takes a comprehensive approach towards mechanics, fundamentals, morphology and properties of Cartilage Tissue and Knee Joints. Leading researchers from health science, medical technologists, engineers, academics, government, and private research institutions across the globe have contributed to this book. This book is a very valuable resource for graduates and postgraduates, engineers and research scholars. The content also includes comprehensive real-world applications. As a reference for the total knee arthroplasty, this book focuses deeply on existing related theories (including: histology, design, manufacturing and clinical aspects) to assist readers in solving fundamental and applied problems in biomechanical and biomaterials characterization, modeling and simulation of human cartilages and cells. For biomedical engineers dealing with implants and biomaterials for knee joint injuries, this book will guide you in learning the knee anatomy, range of motion, surgical procedures, physiological loading and boundary conditions, biomechanics of connective soft tissues, type of injuries, and more. - Provides a comprehensive resource on the knee joint and its connective soft tissues; content included spans biomechanics, biomaterials, biology, anatomy, imaging and surgical procedure - Covers ISO and FDA based regulatory control and compliance in the manufacturing process - Includes discussions on the relationship between knee anatomical parameters and knee biomechanics

Osteoarthritis (OA), the most common form of arthritis, is generally characterized by a slowly progressive degeneration of articular cartilage, particularly in the weight-bearing joints. It has a stronger prevalence in women, and its incidence increases with age. OA is a major and growing health concern in developed countries, owing to steadily increasing life expectancy and the demand for better quality of life. Because of its chronic nature and nonfatal outcome, OA affects the growing population of the elderly over an increasing time span. Moreover, despite its relatively benign character, OA is one of the most disabling diseases; it is responsible for increasing financial and social burdens in terms of medical treatments, forced inactivity, loss of mobility, and dependence. Despite a growing awareness of OA as a medical problem that has yet to reach its maximum impact on society, there is a surprising absence of effective medical treatments beyond pain control and surgery. So far, only symptom-modifying drugs are available, while there remains a major demand for disease-modifying treatments of proven clinical efficacy. This demand will hopefully be met in the future by some of the drugs that have been pressed into development and are now at different stages of clinical investigation. Nevertheless, the current lack of effective treatments reflects a still insufficient knowledge of cartilage with respect to its metabolism, interactions with other joint tissues, and causes and mechanisms (possibly of very different nature) leading to failure of its turnover.

Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies. - Comprehensively covers the interdisciplinary field of regenerative medicine with contributions from leaders in tissue engineering, cell and developmental biology, biomaterials sciences, nanotechnology, physics, chemistry, bioengineering and surgery - Includes new chapters devoted to iPS cells and other alternative sources for generating stem cells as written by the scientists who made the breakthroughs - Edited by a world-renowned team to present a complete story of the development and promise of regenerative medicine

Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.