An understanding of the molecular pathogenesis of colorectal cancer by researchers and clinicians is essential to facilitate progress in improving patient outcomes in this common cancer that still carries a poor prognosis if not identified early. This book covers the major areas of importance in the field, incorporating new knowledge that has arisen due to the advancement of molecular techniques and the ability to correlate molecular changes with clinical behaviour of tumours. Each chapter is a summary written by experts, concisely summarising current data as well as highlighting potential areas for advancement. Appreciating the differences between tumours on a molecular level is the key to developing and delivering precision medicine, and nowhere is this more critically required than in the field of colorectal cancer.

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Rectal cancer is one of the most prevalent cancers world-wide. It is also a paradigm for multimodal management, as the combination of surgery, chemotherapy and radiotherapy is often necessary to achieve the optimal outcome. Recently, international experts met in Heidelberg, Germany to discuss the latest developments in the management of rectal cancer, including the anatomic and pathologic basis, staging tools, surgical concepts including fast-track surgery and laparoscopic resection, functional outcome after surgery and the role of radio- and chemotherapy. This monograph summarizes this meeting and gives an extensive overview of the current concepts in management of rectal cancer.

From surgery to chemotherapy and radiotherapy, attempts to conquer colorectal cancer have been ongoing for a century. Due to these efforts, the mortality rate of colorectal cancer has decreased by about 3% per year for the past 10 years. Progress in reducing mortality from colorectal cancer can be accelerated by improving screening and the use of standard care in all populations. In recent years, advanced knowledge and technologies for better efficiency in targeting colorectal cancer have been developed to improve conventional therapeutics or to propose new therapies as standard regimens. This book discusses diagnostics as well as surgical techniques using robotics, immunotherapy, and radiology-based therapy for colorectal cancer. The section on diagnostics provides information on proteomics, organoid culture techniques, and various candidate markers. The section on treatment discusses robotic surgical techniques for rectal cancer care and multidisciplinary approaches for colorectal cancer treatment. The book also examines the latest in supportive care from a nutritional and metabolic point of view.

For the lay reader wishing to know more about colon cancer, this handbook gives concise information and explanation on diagnosis, prognosis, and treatment. Illustrations.

This book presents an Asian perspective on how the treatment of colorectal cancer can be optimized and standardized in ways that take into account technological advances and the trend towards individually tailored therapy. Readers will find careful, well-illustrated descriptions of the standard surgical techniques for rectal cancer and colon cancer that have contributed to recent improvements in 5-year survival rates in the Asia-Pacific region, where the incidence of colorectal cancer has been rising alarmingly due to lifestyle changes. The vital role now being played by minimally invasive laparoscopic and robotic options receives detailed scrutiny. Extent and timing of surgery, patient safety, risk of complications, and unresolved issues are all discussed. Furthermore, the use of surgery within the context of multimodal management including chemotherapy and radiotherapy is explained and an integrated approach for stage IV and recurrent disease is described. The book will serve as a valuable reference for young surgeons who are in training, experienced practitioners who want to enhance their knowledge and skills, and all others who wish to learn about this field.