Among the topics covered in Volume 49 are neurotransmitter transporters circadian rhythms, transgenic model for studying isles development, protein phosphateses, the androgen receptor, molecular genetics of steroid 5oz-reductases and benign and malignant prostatic neoplasms.

Recent Progress in Hormone Research, Volume 50: Proceedings of the 1993 Laurentian Hormone Conference focuses on the advancements of processes, methodologies, techniques, and approaches involved in hormone research. The selection first offers information on the molecular design of the NMDA receptor channel; synthesis and signaling of growth hormone-releasing hormone; and signaling mechanisms during the response of pituitary gonadotropes to GnRH. The discussions focus on calcium economy of gonadotropes, role of oscillations, structure and expression of the GHRH gene, transgenic animal models for GHRH action, and functional determinants in NMDA receptors. The text then elaborates on signaling mechanisms during the response of pituitary gonadotropes to GnRH; molecular genetic analysis of cAMP and glucocorticoid signaling in development; and activins and the receptor serine kinase superfamily. The publication takes a look at MAP kinase cascade, expression and signal transduction pathways of gonadotropin-releasing hormone receptors, ovarian cell differentiation, and the role of oxytocin and its receptor in parturition. The book also examines the role of prolactin in developmental differentiation of hypophysiotropic tuberoinfundibular dopaminergic neurons and calcitonin gene expression in rat uterus during pregnancy. The selection is a valuable source of data for researchers interested in hormone research. - Neuroendocrinology - Transmembrane signaling - Reproduction - Steroids and the steroid receptor family - Hypertension

Includes Part 1A: Books and Part 1B: Pamphlets, Serials and Contributions to Periodicals

Vols. 1- issued as "Proceedings of the Laurentian Hormone Conference".

This volume is a collection of the most significant contributions to the 4th International Symposium on MULTIPLE RISK FACTORS IN CARDIOVASCULAR DISEASE: STRATEGIES OF PREVENTION OF CORONARY HEART DISEASE, CARDIAC F AlLURE, AND STROKE held in Washington, D. C. in April 1997. The meeting focused on the risk factors for cardiovascular disease and their interactions. The need for this symposium is based on the epidemiological, clinical, and biological evidence that individuals from industrialized countries often possess two or more risk factors which synergistically increase the global risk profile. This has become more evident in recent years with the increase in life expectancy of populations in the industrialized countries. The evidence that a combination of risk factors confers a very high risk of developing cardiovascular diseases, is of pivotal interest in the process of detection of patients who will benefit the most from pharmacological treatment. Many recent epidemiological data identifying the intrinsic and environmental factors contributing to the development of atherosclerosis are discussed. These results, in parallel with basic and clinical research, underline atherosclerosis as a complex and multifactorial process involving the influences of lipids, including lipoprotein subfractions, blood pressure rheologic forces, carbohydrate tolerance, and thrombogenic factors, including fibrinogen, tissue factor, PAl-I, and homocysteine. Furthennore, the risk associated with anyone of these risk factors varies widely depending on the level of the associated atherogenic risk factors. Hyper cholesterolemia and hypertriglyceridemia, for instance, are more common than would be expected by chance among hypertensive patients.

Inspired by Carlos Beyer’s 50 years of pioneering research and influence on his students and colleagues, Behavioral Neuroendocrinology builds upon Beyer’s fundamental discoveries and concepts as well as their widespread implications. It presents original research and reviews on mechanisms — genomic and non-genomic — of steroid and protein hormone action; the role of steroid metabolism, especially aromatization, protein phosphorylation, and neurotransmitter action in mediating reproductive behavior and sexual differentiation; and brain and spinal cord mechanisms in sexual behavior and analgesia. This book presents a rich diversity of topics — lactation, maternal behavior, pheromone action, chronobiology, allodynia, angiogenesis, prostate physiology, sexual motivation, and specific brain systems, including vomeronasal system, cerebellum, preoptic area, hypothalamus, and spinal cord. This book brings together, in one source, an international "family" of researchers whose work has evolved in diverse but related ways from a seminal set of discoveries and concepts in behavioral neuroendocrinology.