Apple Best Books of 2021 Longlisted for the Andrew Carnegie Medal * Shortlisted for the Zocalo Book Prize From the New York Times bestselling author of Dreamland, a searing follow-up that explores the terrifying next stages of the opioid epidemic and the quiet yet ardent stories of community repair. Sam Quinones traveled from Mexico to main streets across the U.S. to create Dreamland, a groundbreaking portrait of the opioid epidemic that awakened the nation. As the nation struggled to put back the pieces, Quinones was among the first to see the dangers that lay ahead: synthetic drugs and a new generation of kingpins whose product could be made in Magic Bullet blenders. In fentanyl, traffickers landed a painkiller a hundred times more powerful than morphine. They laced it into cocaine, meth, and counterfeit pills to cause tens of thousands of deaths-at the same time as Mexican traffickers made methamphetamine cheaper and more potent than ever, creating, Sam argues, swaths of mental illness and a surge in homelessness across the United States. Quinones hit the road to investigate these new threats, discovering how addiction is exacerbated by consumer-product corporations. “In a time when drug traffickers act like corporations and corporations like traffickers,” he writes, “our best defense, perhaps our only defense, lies in bolstering community.” Amid a landscape of despair, Quinones found hope in those embracing the forgotten and ignored, illuminating the striking truth that we are only as strong as our most vulnerable. Weaving analysis of the drug trade into stories of humble communities, The Least of Us delivers an unexpected and awe-inspiring response to the call that shocked the nation in Sam Quinones's award-winning Dreamland.

The question how alcohol alters mood states and why this may end up becoming an addiction is puzzling alcohol researchers since decades. In this volume, an assembly of highly distinguished experts and leaders in alcohol addiction research provides lucid presentations of the current knowledge and research challenges as well as interesting viewpoints on future research directions aimed to stimulate communication and convergence between clinical and preclinical researchers, and to renew interest in the vibrant field of alcohol addiction research among a wide scientifically minded audience. Five Current Topics are discussed in this volume: Neurobiological mechanisms of alcoholism, Genetics, Clinical phenotypes and their preclinical models, Brain imaging, and Translational approaches for treatment development, both pharmacological and non-pharmacological. These areas have in our opinion brought alcohol research substantially forward and influenced our thinking about how to reach our common paramount goal, namely to offer effective treatment solutions for an extensive group of patients with largely unmet medical needs.

INSTANT NEW YORK TIMES and LOS ANGELES TIMES BESTSELLER “Brilliant . . . riveting, scary, cogent, and cleverly argued.”—Beth Macy, author of Dopesick, as heard on Fresh Air This book is about pleasure. It’s also about pain. Most important, it’s about how to find the delicate balance between the two, and why now more than ever finding balance is essential. We’re living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting, Facebooking, Instagramming, YouTubing, tweeting . . . The increased numbers, variety, and potency is staggering. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. As such we’ve all become vulnerable to compulsive overconsumption. In Dopamine Nation, Dr. Anna Lembke, psychiatrist and author, explores the exciting new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain . . . and what to do about it. Condensing complex neuroscience into easy-to-understand metaphors, Lembke illustrates how finding contentment and connectedness means keeping dopamine in check. The lived experiences of her patients are the gripping fabric of her narrative. Their riveting stories of suffering and redemption give us all hope for managing our consumption and transforming our lives. In essence, Dopamine Nation shows that the secret to finding balance is combining the science of desire with the wisdom of recovery.

Explore the brain and discover the clinical and pharmacological issues surrounding drug abuse and dependence. The authors, research scientists with years of experience in alcohol and drug studies, provide definitions, historic discoveries about the nervous system, and original, eye-catching illustrations to discuss the brain/behavior relationship, basic neuroanatomy, neurophysiology, and the mechanistic actions of mood-altering drugs. You will learn about: • how psychoactive drugs affect cognition, behavior, and emotion • the brain/behavior relationship • the specific effects of major addictive and psychoactive drug groups • new definitions and thinking about abuse and dependence • the medical and forensic consequences of drugs use Drugs, the Brain, and Behavior uses a balance of instruction, illustrations, and tables and formulas that will give you a broad, lasting introduction to this intriguing subject. Whether you're a nurse, chemical dependency counselor, psychologist, or clinician, this book will be a quick reference guide long after the first reading.

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

“This masterpiece of dogged and loving reporting will astonish you and touch your heart. The struggles and quest for redemption of football star Jackie Wallace make for a fall-from-grace tale that’s both unsettling and uplifting.”—Walter Isaacson, author of Steve Jobs and Leonardo da Vinci The heartbreaking, timeless, and redemptive story of the transformative friendship binding a fallen-from-grace NFL player and a Pulitzer Prize-winning photojournalist who meet on the streets of New Orleans, offering a rare glimpse into the precarious world of homelessness and the lingering impact of systemic racism and poverty on the lives of NOLA’s citizens. In 1990, while covering a story about homelessness for the New Orleans Times-Picayune, Ted Jackson encountered a drug addict sleeping under a bridge. After snapping a photo, Jackson woke the man. Pointing to the daily newspaper by his feet, the homeless stranger looked the photojournalist in the eye and said, “You ought to do a story about me.” When Ted asked why, he was stunned by the answer. “Because, I’ve played in three Super Bowls.” That chance meeting was the start of Ted’s thirty-year relationship with Jackie Wallace, a former NFL star who rose to the pinnacle of fame and fortune, only to crash and lose it all. Getting to know Jackie, Ted learned the details of his life, and how he spiraled into the “vortex of darkness” that left him addicted and living on the streets of New Orleans. Ted chronicles Jackie's life from his teenage years in New Orleans through college and the NFL to the end of his pro career and the untimely death of his mother—devastating events that led him into addiction and homelessness. Throughout, Ted pays tribute to the enduring friendship he shares with this man he has come to know and also look at as an inspiration. But Ted is not naïve; he speaks frankly about the vulnerability of such a relationship: Can a man like Jackie recover, or is he destined to roam the streets until his end? Tragic and triumphant, inspiring and unexpected, You Ought to Do a Story About Me offers a rare glimpse into the precarious world of homelessness and the lingering impact of racism and poverty on the lives of NOLA’s citizens. Lyrical and evocative, Ted's account is pure, singular, and ambitious—a timeless tale about loss, redemption, and hope in their multifarious forms. “This book will melt your heart. The story of Jackie Wallace is an unforgettable tale of hope, grace, and the miracle of the human spirit. Ted Jackson writes with searing honesty and deep love for a troubled man who started as his subject and became his lifelong friend.”—Jonathan Eig, bestselling author of Ali: A Life and Luckiest Man: The Life and Death of Lou Gehrig