Provides a concise and authoritative reference on the use of vaccines against diseases of livestock Compiled by Senior Animal Health Officers at The Food and Agriculture Organization of the United Nations, and with contributions from international leading experts, Veterinary Vaccines: Principles and Applications is a concise and authoritative reference featuring easily readable reviews of the latest research in vaccinology and vaccine immune response to pathogens of major economic impact to livestock. It covers advice and recommendations for vaccine production, quality control, and effective vaccination schemes including vaccine selection, specifications, vaccination programs, vaccine handling in the field, application, failures, and assessment of herd protection. In addition, the book presents discussions on the current status and potential future developments of vaccines and vaccination against selected transboundary animal diseases. Provides a clear and comprehensive guide on using veterinary vaccines to protect livestock from diseases Teaches the principles of vaccinology and vaccine immune response Highlights the vaccine production schemes and standards for quality control testing Offers easy-to-read reviews of the most current research on the subject Gives readers advice and recommendations on which vaccination schemes are most effective Discusses the today’s state of vaccines and vaccination against selected transboundary animal diseases as well as possible future developments in the field Veterinary Vaccines: Principles and Applications is an important resource for veterinary practitioners, animal health department officials, vaccine scientists, and veterinary students. It will also be of interest to professional associations and NGO active in livestock industry.

In the case of livestock, control of the major epizootic diseases will be a prime requirement for increased production in the developing world. Veterinary vaccines are a major factor in programmes to bring the economically important diseases under control. They must be effective, consistent in performance and economically affordable. The book will help to protect farmers in the developing countries from the effects of poor-quality veterinary vaccines and will contribute to the welfare of livestock as well as the global control of animal diseases. Contents Part I: Overview on Veterinary Vaccines for Developing Countries Chapter 1: Regional Harmonization of Vaccine Quality Standards and Stimulation of Vaccine Technologies in Developing Countries by M M Rweyemamu, D Sylla nad V Palya, Chapter 2: Profiles of Veterinary Vaccine Production and Quality Control in Developing and Less Advanced Countries: Vaccines for Livestock by P C Lefevre, Chapter 3: Profiles of Veterinary Vaccines Production and Quality Control in Developing and Less Advanced Countries: Vaccines for Poultry by A L Ibrahim and L H Seng, Chapter 4: Veterinary Vaccine Production and Quality Control in Developing and Less Advanced Countries by F G Davies, Discussion. Part II: Veterinary Vaccine Production and Qulaity Control Facilities in Different Regions of the World Country Reports: Africa: Chapter 1: Eradication Policy for Foot-and-Mouth Diseases in Botswana by M Mannathoko, Chapter 2: Production and Quality Control of Vaccine at the National Veterinary Laboratory, Garoua (Cameroon) by N Zoyem, Chapter 3: Vaccine Production and Quality Control in Ethiopia by G Y Mebratu, Chapter 4: The Kenya Veterinary Vaccine Production Unit (KEVEVAPI) by R Korir, Chapter 5: Vaccine Production in West Africa: Sengal and Mali by D Sylla nad M Rweyemamu, Chapter 6: Quality Control of Modified Living Viral Vaccines in Libya Somalia and Czechoslovakia by V Rozkosny, Chapter 7: Vaccine Production and Control in Syria by G Khoury. Asia and the Pacific Region; Chapter 8: Production and Quality Control Systems for Veterinary Bioproducts in China by T Guiyun, Chapter 9: Vaccine Production and Quality Control in India by P N Bhat, Chapter 10: The Activities of the Veterinary Drug Assay Laboratories, Gujungsindur, Bogor, Indonesia by S B Siregar, Chapter 11: Vaccine Production and Quality Control in Malaysia by A L Ibrahim and L H Seng. Latin America; Chapter 12: Foot-and-Mouth Disease Virus Production and Control of Vaccines in South America by R A Casas Olascoaga. Europe; Chapter 13: Vaccine Control in Italy by M Tollis, Chapter 14: Vaccine Production and Control in France by R M Lombard, Chapter 15: Vaccine Production and Quality Control in Poland by Z Pejsak and J Gorski, Chapter 16: Vaccine Production and Control in Hungary by V Palya, Discussion. Part III: Some Technical Aspects of Vaccine Production and Quality Control: Chapter 1: Live Viral Vaccines by L E Carmichael, Inactivated Viral Vaccines by L E Carmichael, Chapter 3: Viral Vaccines Produced in Embryonating Eggs by L E Carmichael, Discussion, Chapter 4: Contagious Bovince Pleuropneumonia Vaccine Production and Quality Control by P C Lefevre, Chapter 5: The Quality Control of Vaccines Against Brucellosis by J De Ryke, Chapter 6: Industrial Production and Quality Control of Veterinary Vaccines by L K Nagy, Discussion, Chapter 7: Protozoal and Rickettsial with Special Reference to Quality Control by F L Musisi, J A Lawrence, J C Quiroga, S P Kamwendo and J Malika, Discussion. Part IV: Specific Issues to Veterinary Vaccines Chapter 1: Modern Trends Related to Veterinary Vaccines by T R Doel, Chapter 2: Genetically Engineered Vaccines by T Yilma, Chapter 3: Attenuation of Virulence and Enhancement of Immunogenicity by T Yilma, Discussion. Part V: Major Vaccination Campaigns in Developing Countries Chapter 1: The Role of PANVAC in the Quality Control of Veterinary Vaccines for Major Vaccination Programmes in Africa by D Sylla, M Rweyemamu, V Palya, and J Prandota, Chapter 2: Global Strategies for Rinderpest Eradication by K J Wojciechowski, Discussion, Chapter 3: Office International des Epizooties: Activities Related to Veterinary Vaccines Quality Control by Y Ozawa, Chapter 4: Continental Strategy in the Fight Against Foot-and-Mouth Disease in Latin America by R Casas Olascoaga, Chapter 5: Newcastle Disease Control in Rural Poultry: Overview on Quality Control of Food Based Newcastle Disease Vaccine by A L Ibrahim, Chapter 6: Rinderpest Vaccine Quality Control by the Pan African Veterinary Vaccine Centre (PANVAC) by M Rweyemanu, D Sylla, V Palya, J Prandota and K J Wojciechowski, Chapter 7: Seromonitoring of Post Vaccinal Immunity by J M Jeggo. Part VI: Vaccine Banks and Emergency Stocks of Vaccine Against Exotic Diseases Chapter 1: The Plum Island (USA) Model by C A Mebus, Chapter 2: International Vaccine Banks by T R Doel, Discussion. Part VII: Special Presentations Chapter 1: Anti Rabies Vaccines: Feasibility of Joint Control of Medical and Veterinary Vaccines by O Thraenhart, Chapter 2: The Role of Molecular Biology in Quality Control of Veterinary Vaccines and Biologicals by C A Mebus, Chapter 3: Development and Transfer of Vaccine Technology to the Third World: Long Term Challenges and Strategies BIOFORCE 95 by A Atger. Part VIII: Constraints to Vaccine Production Chapter 1: Constraints in Vaccine Production and Quality Control in Developing Countries by F G Davies, Chapter 2: Technical Financail and Socio Economic Constraints on Vaccine Production in Africa by L E Carmichael and D Sylla. Part IX: Licensing and Quality Control Chapter 1: Licensing and Quality Control of DNA Technology Products by C A Mebus, Chapter 2: Licensing of Veterinary Vaccines and Biologicals by J M Rutter, Discussion.

Hardbound. Vaccination is widely recognised as one of the most efficient tools in public health, showing obvious cost-benefit advantages for all target populations involved.Vaccines in the veterinary field can contribute greatly to the welfare of domestic and wild animals and, indirectly, to environmental protection. The aim of animal vaccination will increasingly be to prevent dissemination of zoonoses (such as rabies, taeniosis, salmonellosis, etc.) rather than to protect the animal itself, especially when infection or infestation is not harmful to the reservoir (cysticercosis)At present there is insufficient overall understanding of some important aspects of veterinary vaccines. Literature on the subject exists, but often consists of either research communications or 'catalogue-type' descriptive works. This unique book fills a gap within the already available literature. The scope is broad and covers all aspects of vaccines and vaccination in the

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This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.