Obsessive-compulsive disorder affects approximately one person in 40 and causes great suffering. Effective treatments are available that can help many, and our understanding of the psychology, neurobiology, and clinical treatment of the disorder has advanced dramatically over the past 25 years. Nevertheless, much remains to be learned, and a substantial minority of patients benefit little even from the best treatments we have to offer today. This volume provides the first comprehensive summary of the state of the field, summarizing topics ranging from genetics and neurobiology through cognitive psychology, clinical treatment, related conditions, societal implications, and personal experiences of patients and clinicians. This book is unique in its comprehensive coverage that extends far beyond the realm of cognitive-behavioral therapy. As such it will serve as a valuable introduction to those new to the field, a fascinating resource for OCD suffers and their families, and an essential reference for students, clinicians, and researchers.

Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. - Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics - Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry - Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. - Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics - Identifies key concepts, methods, and findings - Includes coverage of multiple disorders from autism to schizophrenia - Reviews specific genes associated with disorders - Discusses the genetic architecture of these syndromes - Explains how recent findings are influencing the understanding of biology - Clarifies the promise of these findings for future treatment

A comprehensive, full-color guide to the principles and practice of neuropsychiatry and behavioral neurology. A primary resource in the field A Doody's Core Title for 2023! From the world-renowned experts at the Center for Brain/Mind Medicine at Brigham and Women’s Hospital and Harvard Medical School, Neuropsychiatry and Behavioral Neurology delivers authoritative, multidisciplinary information and insights for improving patient care. Chapter authors include additional worldwide academic clinician leaders from sister institutions. Covering the latest advances in cognitive, affective, and behavioral neuroscience, the text provides a practical and clearly written approach to structural and functional neuroanatomy; neuropsychiatric and behavioral neurology assessments and treatments; and neurobehavioral/neuropsychiatric syndromes and disorders. Neuropsychiatry and Behavioral Neurology includes: A definitive introductory chapter on the neuroanatomy of cognitive and behavioral neuroscience Chapters on the neurocircuitry of emotions and cognition Chapters on neuropsychiatric assessment methods and therapeutics, including pharmacology and neurostimulation modalities Chapters on neurobehavioral and neuropsychiatric syndromes, as well as on neuropsychiatric aspects of different neurological and medical diseases Numerous full-color illustrations of brain anatomy High-resolution brain CT and MRI scans Summaries and key points, patient cases, and multiple choice questions with annotated answers Evidence-based updates, combined with clinical guidance from master academic clinician Whether you’re a trainee, recent graduate, seasoned practicing clinician, or investigator interested in linking basic neuroscience research to clinical care, you’ll find everything you need to determine the neurobiological origins of alterations in emotion, cognition, and behavior; contextualize the illness to emphasize the role of underlying brain circuitry; develop informed differential diagnoses; and plan and implement the most effective treatment strategies. This text meets the curriculum requirements needed to prepare for board certification in Behavioral Neurology and Neuropsychiatry.

Published on Behalf of the World Health Organization

In this edited volume a group of leading thinkers in psychiatry, psychology, and philosophy offer alternative perspectives that address both the scientific and clinical aspects of psychiatric validation, emphasizing throughout their philosophical and historical considerations.