Process analytical chemistry (PAC) can be defined as the technology of obtaining quantitative and qualitative information about a chemical process in order to control or optimise its performance. This highly practical book provides an up-to-date introduction to the field with a special emphasis placed on industrial processes. Edited by representatives from one of the world's leading chemical companies and centres of excellence for research into the subject, the book is written by a transatlantic team of authors who provide a global perspective.

This practice-oriented book introduces chemists, engineers and technicians to the strategies, techniques and efficiency of modern process analytical chemistry. The author targets in particular those professionals in SMEs who have to carry out process control tasks in a "solo-run".

Process Analytical Technology explores the concepts of PAT and its application in the chemical and pharmaceutical industry from the point of view of the analytical chemist. In this new edition all of the original chapters have been updated and revised, and new chapters covering the important topics of sampling, NMR, fluorescence, and acoustic chemometrics have been added. Coverage includes: Implementation of Process Analytical Technologies UV-Visible Spectroscopy for On-line Analysis Infrared Spectroscopy for Process Analytical Applications Process Raman Spectroscopy Process NMR Spectrscopy: Technology and On-line Applications Fluorescent Sensing and Process Analytical Applications Chemometrics in Process Analytical Technology (PAT) On-Line PAT Applications of Spectroscopy in the Pharmaceutical Industry Future Trends for PAT for Increased Process Understanding and Growing Applications in Biomanufacturing NIR Chemical Imaging This volume is an important starting point for anyone wanting to implement PAT and is intended not only to assist a newcomer to the field but also to provide up-to-date information for those who practice process analytical chemistry and PAT. It is relevant for chemists, chemical and process engineers, and analytical chemists working on process development, scale-up and production in the pharmaceutical, fine and specialty chemicals industries, as well as for academic chemistry, chemical engineering, chemometrics and pharmaceutical science research groups focussing on PAT. Review from the First Edition “The book provides an excellent first port of call for anyone seeking material and discussions to understand the area better. It deserves to be found in every library that serves those who are active in the field of Process Analytical Technology.”—Current Engineering Practice

This book highlights many of the latest developments and trends in engineering chemistry research and describes the respective tools to characterize and predict properties and behavior of materials. The book provides original, theoretical, and important experimental results which use non-routine methodologies and presents chapters on novel applications of more familiar experimental techniques and analyses of composite problems which indicate the need for new experimental approaches presented. Technical and technological development demands the creation of new materials that are stronger, more reliable and more durable, i.e. materials with new properties. This volume presents new research that will help lead to new and better materials. Each chapter describes the principle of the respective method as well as the detailed procedures of experiments with examples of actual applications presented. Thus, readers will be able to apply the concepts as described in the book to their own experiments. Experts in each of the areas covered have reviewed the state of the art, thus creating a book that will be useful to readers at all levels in academic, industry, and research institutions. Engineers, polymer scientists, and technicians will find this volume useful in selecting approaches and techniques applicable to characterizing molecular, compositional, rheological, and thermodynamic properties of elastomers and plastics.

This volume concentrates on the attributes, requirements and applications of spectroscopic techniques in process analysis, considering off-line and at-/near-line methodology, in addition to on-line, in-line and non-invasive approaches. At a time when cost- and time-effective process spectroscopy is becoming an issue of increasing importance within the chemical industry, this volume provides a valuable source of up-to-date information on technological advances in the area. It complements more general works on process analytical chemistry.