A 23-year-old African Caribbean woman presents in the emergency department with an acute onset facial rash. During initial assessment she complains of a two week history of general malaise, fatigue, fever, and weight loss. You have been assigned her examination...100 Cases in Dermatology presents 100 scenarios with a dermatological manifestation co

It is one of the most extraordinary cases in the history of science: the mating calls of insects were mistaken for a “sonic weapon” that led to a major diplomatic row. Since August 2017, the world media has been absorbed in the “attack” on diplomats from the American and Canadian Embassies in Cuba. While physicians treating victims have described it as a novel and perplexing condition that involves an array of complaints including brain damage, the authors present compelling evidence that mass psychogenic illness was the cause of “Havana Syndrome.” This mysterious condition that has baffled experts is explored across 11-chapters which offer insights by a prominent neurologist and an expert on psychogenic illness. A lively and enthralling read, the authors explore the history of similar scares from the 18th century belief that sounds from certain musical instruments were harmful to human health, to 19th century cases of “telephone shock,” and more contemporary panics involving people living near wind turbines that have been tied to a variety of health complaints. The authors provide dozens of examples of kindred episodes of mass hysteria throughout history, in addition to psychosomatic conditions and even the role of insects in triggering outbreaks. Havana Syndrome: Mass Psychogenic Illness and the Real Story Behind the Embassy Mystery and Hysteria is a scientific detective story and a case study in the social construction of mass psychogenic illness.

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.

Comprehensive history of the 200 year-old Royal Society of Medicine, which originated in 1805 when leading members of the Medical Society of London seceded to found a more dynamic society "for the purpose of conversation on professional subjects, for the reception of communications and for the formation of a library."

Climate Change: Evidence and Causes is a jointly produced publication of The US National Academy of Sciences and The Royal Society. Written by a UK-US team of leading climate scientists and reviewed by climate scientists and others, the publication is intended as a brief, readable reference document for decision makers, policy makers, educators, and other individuals seeking authoritative information on the some of the questions that continue to be asked. Climate Change makes clear what is well-established and where understanding is still developing. It echoes and builds upon the long history of climate-related work from both national academies, as well as on the newest climate-change assessment from the United Nations' Intergovernmental Panel on Climate Change. It touches on current areas of active debate and ongoing research, such as the link between ocean heat content and the rate of warming.