A new release in the Quality Chasm Series, Priority Areas for National Action recommends a set of 20 priority areas that the U.S. Department of Health and Human Services and other groups in the public and private sectors should focus on to improve the quality of health care delivered to all Americans. The priority areas selected represent the entire spectrum of health care from preventive care to end of life care. They also touch on all age groups, health care settings and health care providers. Collective action in these areas could help transform the entire health care system. In addition, the report identifies criteria and delineates a process that DHHS may adopt to determine future priority areas.

Start a dangerous adventure with Carrie O'Connor—an elite covert operative of the mysterious CIS—who isn’t burdened by bureaucrats or rule books. The first novel in the Carrie Chronicles series. She didn’t start the fight, but she’ll gladly finish it… While confirming the elimination of a target during a drone attack, Carrie discovers a massive cover-up. Now a target herself, she’s determined to find out who wants her dead, and begins to cut through a complex web of lies and deceit. Even if it means going to war with the CIA. With innocents killed and her own life at stake, how will Carrie survive so that justice is served? Reviews ★★★★★ "...The action's relentless, the tension extreme and the characters remarkably good. Exhausting, but a very satisfying read!" ★★★★★ "Ethan Jones has hit another home run with this new series. It's a real barn-burner, a real page turner that is nonstop action from the first page to the very last page. Having met Carrie first as a character in a Justin Hall thriller I had no doubt that in a series of her own that she would be a winner, but the truth is that the first book in the Carrie series even exceeded my highest expectations and I look forward to reading each new volume as they become available. Five stars doesn't do this book justice, I would have liked to give it a solid ten stars. Give me more Carrie!!!!" ★★★★★ "The CIA has botched a drone strike. Then they try to cover it up by trying to kill anyone who can bring evidence to bear against the first. Innocents have been killed. Canadian clandestine agent O'Connor won't rest until justice is served. An absolutely amazing read !!" ★★★★★ "Loved the book, has everything in it I love - danger, suspense, spies, fighting and a mind bend whilst you work out who the bad guy is! Going to read a lot more of Ethan Jones' books!" The Carrie Chronicle Spy Thriller Series Ethan Jones’ bestselling series confirms his place as a spy fiction master. With hundreds of five-star reviews and thousands of sales and downloads. Each book is a self-contained story without cliffhangers and can be enjoyed on its own. In the vein of bestselling authors Thor, Baldacci, and Flynn, Priority Target is an action-packed adventure that will keep you reading through the night. Scroll, click/tap and start the fantastic, heart-stopping adventure now! If you love assassinations, conspiracies, crime, espionage, military, political, psychological, technothrillers, terrorism, suspense, spy thrillers, secret agents, clandestine covert missions, and action & adventure with series favorites such as Jack Storm, Justin Hall, Javin Pierce, Carrie O’Connor, or Max Thorne… You’ll love this book.

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.