Many of the systemic autoimmune diseases seen in children are different from those seen in adults making them a special problem for physicians and scientists who care for the affected children and study their diseases. Benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties, this volume covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices.

Pediatrics in Systemic Autoimmune Diseases, Second Edition, provides a good starting point for physicians and scientists new to the field and for anyone looking for the most up-to-date summary of a particular disease. While many questions are answered, many more are raised for which we do not yet have the answers. The book provides inspiration to readers conducting their own research and helps to answer their questions. The care of children with systemic autoimmune diseases is moving forward at a rapid pace. The systemic autoimmune diseases of childhood have always represented a special problem for the physicians and scientists who care for the affected children and study their diseases. Some conditions, such as Kawasaki disease, are virtually unique to childhood, while systemic lupus erythematosus, progressive systemic sclerosis, and juvenile onset spondyloarthropathies may be thought of as the early onset of the same disease which is seen in adults. The autoinflammatory disorders appear to be of clear genetic origin, accounting for their frequent discovery in childhood. For many other conditions, such as juvenile dermatomyositis, the relationship between the conditions seen in children and that seen in adults is less certain. This book explores these phenomena, giving users a foundation on which to understand certain diseases. - Includes completely updated chapters and five new chapters - Explains the differences in systemic autoimmune diseases seen in children vs. those seen in adults - Covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices, benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties - Brings the reader up-to-date and allows easy access to individual topics in one place - Provides the latest information available in a format that would give the clinician both a clear understanding of what has been done in the past and a scientific basis for deciding what to do for the next afflicted child in their care

Paediatric Rheumatology is an indispensible resource for the identification and management of specific rheumatological disorders. As well as covering common and rare rheumatological problems, there are also chapters on investigations and emergencies, designed for quick reference. The handbook includes dedicated topics on systemic diseases affecting rheumatology; the relevant clinical guidelines and information needed for a rheumatologist to successfully management a young patient; and, a coloured section for guidance on rash-related investigations. Paediatric Rheumatology is also fully endorsed by the British Society for Paediatric and Adolescent Rheumatology and the UK Paediatric Rheumatology Clinical Studies Group.

Not too long ago, it was thought that inflammation of blood vessels was the sole manifestation of systemic autoimmune diseases. Today, however, we know that disorders of coagulation, injuries to both neutrophils and endothelial cells, and certain lipids and amino acids are all intricately involved in the development of vascular disease. How are all

Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy and memory loss and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, from psychiatry to orthopedics. This book provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved as well as clinical manifestations in both “the thrombotic and “non-thrombotic manifestations of this important disease. Comprehensive review of this major disease Includes information on treatment options available

The purpose of this book is to provide a concise but precise consensus on the impact of uveitis in children and on the diagnostic and therapeutic approaches. Experts in Ocular Immunology and Rheumatology were convened in an effort to provide guidelines in the diagnosis and treatment of uveitis in children. The result of those efforts are captured in this monograph.