This volume is the result of a NATO Advanced Study Institute held in England at Kingswood Hall of Residence, Royal Holloway College (London University), Surrey, during the last two weeks of July, 1976. The ASI was organized within the guide lines laid down by the Scientific Affairs Division of the North Atlantic Treaty Organization. During the past two decades, significant advances have been made in our understanding of vertebrate evolution. The purpose of the Institute was to present the current status of our know ledge of vertebrate evolution above the species level. Since the subject matter was obviously too broad to be covered adequately in the limited time available, selected topics, problems, and areas which are applicable to vertebrate zoology as a whole were reviewed. The program was divided into three areas: (1) the theory and methodology of phyletic inference and approaches to the an alysis of macroevolutionary trends as applied to vertebrates; (2) the application of these methodological principles and an alytical processes to different groups and structures, particular ly in anatomy and paleontology; (3) the application of these re sults to classification. The basic principles considered in the first area were outlined in lectures covering the problems of character analysis, functional morphology, karyological evidence, biochemical evidence, morphogenesis, and biogeography.

'Patterning in Vertebrate Development' is a new volume in the 'Frontiers in Molecular Biology' series which provides a range of comprehensive, and authoritative reviews of current research into patterning, a fundamental process in developmental biology.

Eggs of all animals contain mRNAs and proteins that are supplied to or deposited in the egg as it develops during oogenesis. These maternal gene products regulate all aspects of oocyte development, and an embryo fully relies on these maternal gene products for all aspects of its early development, including fertilization, transitions between meiotic and mitotic cell cycles, and activation of its own genome. Given the diverse processes required to produce a developmentally competent egg and embryo, it is not surprising that maternal gene products are not only essential for normal embryonic development but also for fertility. This review provides an overview of fundamental aspects of oocyte and early embryonic development and the interference and genetic approaches that have provided access to maternally regulated aspects of vertebrate development. Some of the pathways and molecules highlighted in this review, in particular, Bmps, Wnts, small GTPases, cytoskeletal components, and cell cycle regulators, are well known and are essential regulators of multiple aspects of animal development, including oogenesis, early embryogenesis, organogenesis, and reproductive fitness of the adult animal. Specific examples of developmental processes under maternal control and the essential proteins will be explored in each chapter, and where known conserved aspects or divergent roles for these maternal regulators of early vertebrate development will be discussed throughout this review. Table of Contents: Introduction / Oogenesis: From Germline Stem Cells to Germline Cysts / Oocyte Polarity and the Embryonic Axes: The Balbiani Body, an Ancient Oocyte Asymmetry / Preparing Developmentally Competent Eggs / Egg Activation / Blocking Polyspermy / Cleavage/ Mitosis: Going Multicellular / Maternal-Zygotic Transition / Reprogramming: Epigenetic Modifications and Zygotic Genome Activation / Dorsal-Ventral Axis Formation before Zygotic Genome Activation in Zebrafish and Frogs / Maternal TGF-β and the Dorsal-Ventral Embryonic Axis / Maternal Control After Zygotic Genome Activation / Compensation by Stable Maternal Proteins / Maternal Contributions to Germline Establishment or Maintenance / Perspective / Acknowledgments / References

The factors that influenced the evolution of the vertebrates are compared with the importance of variation and selection that Darwin emphasised in this broad study of the patterns and forces of evolutionary change.

This book vividly describes how complex and integrated movements can arise from the properties and behaviors of biological molecules. It provides a uniquely integrated account in which the latest findings from biophysics and molecular biology are put into the context of living cells. This second edition is updated throughout with recent advances in the field and has a completely revised and redrawn art program. The text is suitable for advanced undergraduates, graduate students, and for professionals wishing for an overview of this field.

This text provides a broad but authoritative view of the cellular and molecular aspects of developmental neurobiology written by leaders in the field.