Pattern Formation in Morphogenesis is a rich source of interesting and challenging mathematical problems. The volume aims at showing how a combination of new discoveries in developmental biology and associated modelling and computational techniques has stimulated or may stimulate relevant advances in the field. Finally it aims at facilitating the process of unfolding a mutual recognition between Biologists and Mathematicians of their complementary skills, to the point where the resulting synergy generates new and novel discoveries. It offers an interdisciplinary interaction space between biologists from embryology, genetics and molecular biology who present their own work in the perspective of the advancement of their specific fields, and mathematicians who propose solutions based on the knowledge grasped from biologists.

This text explores the use of cellular automata in modeling pattern formation in biological systems. It describes several mathematical modeling approaches utilizing cellular automata that can be used to study the dynamics of interacting cell systems both in simulation and in practice. New in this edition are chapters covering cell migration, tissue development, and cancer dynamics, as well as updated references and new research topic suggestions that reflect the rapid development of the field. The book begins with an introduction to pattern-forming principles in biology and the various mathematical modeling techniques that can be used to analyze them. Cellular automaton models are then discussed in detail for different types of cellular processes and interactions, including random movement, cell migration, adhesive cell interaction, alignment and cellular swarming, growth processes, pigment cell pattern formation, tissue development, tumor growth and invasion, and Turing-type patterns and excitable media. In the final chapter, the authors critically discuss possibilities and limitations of the cellular automaton approach in modeling various biological applications, along with future research directions. Suggestions for research projects are provided throughout the book to encourage additional engagement with the material, and an accompanying simulator is available for readers to perform their own simulations on several of the models covered in the text. QR codes are included within the text for easy access to the simulator. With its accessible presentation and interdisciplinary approach, Cellular Automaton Modeling of Biological Pattern Formation is suitable for graduate and advanced undergraduate students in mathematical biology, biological modeling, and biological computing. It will also be a valuable resource for researchers and practitioners in applied mathematics, mathematical biology, computational physics, bioengineering, and computer science. PRAISE FOR THE FIRST EDITION “An ideal guide for someone with a mathematical or physical background to start exploring biological modelling. Importantly, it will also serve as an excellent guide for experienced modellers to innovate and improve their methodologies for analysing simulation results.” —Mathematical Reviews

This 121st IMA volume, entitled MATHEMATICAL MODELS FOR BIOLOGICAL PATTERN FORMATION is the first of a new series called FRONTIERS IN APPLICATION OF MATHEMATICS. The FRONTIERS volumes are motivated by IMA pro grams and workshops, but are specially planned and written to provide an entree to and assessment of exciting new areas for the application of mathematical tools and analysis. The emphasis in FRONTIERS volumes is on surveys, exposition and outlook, to attract more mathematicians and other scientists to the study of these areas and to focus efforts on the most important issues, rather than papers on the most recent research results aimed at an audience of specialists. The present volume of peer-reviewed papers grew out of the 1998-99 IMA program on "Mathematics in Biology," in particular the Fall 1998 em phasis on "Theoretical Problems in Developmental Biology and Immunol ogy." During that period there were two workshops on Pattern Formation and Morphogenesis, organized by Professors Murray, Maini and Othmer. James Murray was one of the principal organizers for the entire year pro gram. I am very grateful to James Murray for providing an introduction, and to Philip Maini and Hans Othmer for their excellent work in planning and preparing this first FRONTIERS volume. I also take this opportunity to thank the National Science Foundation, whose financial support of the IMA made the Mathematics in Biology pro gram possible.

This Lecture Notes Volume represents the first time any of the summer school lectures have been collected and published on a discrete subject rather than grouping all of a season's lectures together. This volume provides a broad survey of current thought on the problem of pattern formation. Spanning six years of summer school lectures, it includes articles which examine the origin and evolution of spatial patterns in physio-chemical and biological systems from a great diversity of theoretical and mechanistic perspectives. In addition, most of these pieces have been updated by their authors and three articles never previously published have been added.

On Growth and Form Spatio-temporal Pattern Formation in Biology M. A. J. Chaplain and G. D. Singh, both of the University of Dundee, UK J. C. McLachlan, St. Andrews University, UK Spatio-temporal pattern formation is a major area of research within the subject of mathematical biology. The topic involves the use of mathematical modelling to analyse how patterns in biology are created and develop. For example, the growth, over time, of the intricate and beautiful patterns on certain sea-shells or the striped markings on a tiger can be modelled and their development predicted in terms of non-linear mathematical processes. The current volume captures the breadth of recent research into various aspects of spatio-temporal pattern and form, such as development biology, reaction-diffusion systems and morphometrics. * Brings the ideas of the classic On Growth and Form by D'Arcy Thompson, the founding classic of mathematical biology, fully up to date and looks to future developments in the subject * Foreword provided by Professor John Tyler Bonner, Princeton University * World class collection of internationally renowned contributors from both experimental and theoretical backgrounds Taking its inspiration from D'Arcy Thompson's classic and still influential volume On Growth and Form, this new volume presents a collection of 21 articles from the Plenary Speakers of the recent D'Arcy Thompson Conference, held at the University of Dundee, 20-24 September 1998. The topics covered include pattern formation in development biology, reaction-diffusion systems, intercellular systems and morphometrics, offering the reader a stimulating blend of theory and experiment. This book will be of particular interest to bio-mathematicians and development biologists. Paediatric clinicians, evolutionary biologists, orthodontists, anatomists, physiologists and many other members of the biology community will also benefit greatly from it.

Fully illustrated mathematical guide to pattern formation. Includes instructive exercises and examples.