Now an award-winning documentary feature film The search for a “patient zero”—popularly understood to be the first person infected in an epidemic—has been key to media coverage of major infectious disease outbreaks for more than three decades. Yet the term itself did not exist before the emergence of the HIV/AIDS epidemic in the 1980s. How did this idea so swiftly come to exert such a strong grip on the scientific, media, and popular consciousness? In Patient Zero, Richard A. McKay interprets a wealth of archival sources and interviews to demonstrate how this seemingly new concept drew upon centuries-old ideas—and fears—about contagion and social disorder. McKay presents a carefully documented and sensitively written account of the life of Gaétan Dugas, a gay man whose skin cancer diagnosis in 1980 took on very different meanings as the HIV/AIDS epidemic developed—and who received widespread posthumous infamy when he was incorrectly identified as patient zero of the North American outbreak. McKay shows how investigators from the US Centers for Disease Control inadvertently created the term amid their early research into the emerging health crisis; how an ambitious journalist dramatically amplified the idea in his determination to reframe national debates about AIDS; and how many individuals grappled with the notion of patient zero—adopting, challenging and redirecting its powerful meanings—as they tried to make sense of and respond to the first fifteen years of an unfolding epidemic. With important insights for our interconnected age, Patient Zero untangles the complex process by which individuals and groups create meaning and allocate blame when faced with new disease threats. What McKay gives us here is myth-smashing revisionist history at its best.

An investigative account of the medical, sexual, and scientific questions surrounding the spread of AIDS across the country.

An updated edition of Jacques Pépin's acclaimed account of the events that transformed a chimpanzee virus into a global pandemic.

Engrossing true stories of the pioneers of epidemiology who risked their lives to find the source of deadly diseases—now revised to include updated information and a new chapter on Covid-19. More people have died in disease epidemics than in wars or other disasters, but the process of identifying these diseases and determining how they spread is often a terrifying gamble. Epidemiologists have been ignored, mocked, or silenced all while trying to protect the population and identify “patient zero”—the first person to have contracted the disease, and a key piece in solving the epidemic puzzle. Patient Zero tracks the gripping tales of eight epidemics and pandemics—how they started, how they spread, and the fight to stop them. This revised edition combines a brand-new design with updated information and features diseases such as Spanish Influenza, Ebola, and AIDS, as well as a new chapter on Covid-19.

From the Castro bathhouses to AZT and the denial of AIDS in South Africa, this sweeping look at AIDS covers the epidemic from all angles and across the world. Engel seamlessly weaves together science, politics, and culture, writing with an even hand—noting the excesses of the more radical edges of the ACT UP movement as well as the conservative religious leaders who thought AIDS victims deserved what they got. The story of AIDS is one of the most compelling human dramas of our time, both in its profound tragedy and in the extraordinary scientific efforts impelled on its behalf. For gay Americans, it has been the story of the past generation, redefining the community and the community's sexuality. For the Third World, AIDS has created endless devastation, toppling economies, social structures, and whole villages and regions. And the worst may yet be to come: AIDS is expanding quickly into India, Russia, China, and elsewhere, while still raging in sub-Saharan Africa. A distinguished medical historian, Engel lets his characters speak for themselves. Whether gay activists, government officials, public health professionals, scientists, or frightened parents of schoolchildren, they responded as best they could to tragic happenstance that emerged seemingly from nowhere. There is much drama here, and human weakness and heroism too. Writing with vivid immediacy, Engel allows us to relive the short but tumultuous history of a modern scourge.

In 1992, Dr. Ross A. Slotten signed more death certificates in Chicago—and, by inference, the state of Illinois—than anyone else. As a family physician, he was trained to care for patients from birth to death, but when he completed his residency in 1984, he had no idea that many of his future patients would be cut down in the prime of their lives. Among those patients were friends, colleagues, and lovers, shunned by most of the medical community because they were gay and HIV positive. Slotten wasn’t an infectious disease specialist, but because of his unique position as both a gay man and a young physician, he became an unlikely pioneer, swept up in one of the worst epidemics in modern history. Plague Years is an unprecedented first-person account of that epidemic, spanning not just the city of Chicago but four continents as well. Slotten provides an intimate yet comprehensive view of the disease’s spread alongside heartfelt portraits of his patients and his own conflicted feelings as a medical professional, drawn from more than thirty years of personal notebooks. In telling the story of someone who was as much a potential patient as a doctor, Plague Years sheds light on the darkest hours in the history of the LGBT community in ways that no previous medical memoir has.

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.