Doctors Pellet, Cannoni and Pech have joined forces to write a masterly work on the subject of otoneurosurgery and tumors of the base of the skull. The anatomic illustrations, derived from their meticulous dissections, are of excellent quality and a credit to the famed tradition of French neuroanatomists of the past. It is evident that the operative techniques described by these surgeons indicate that they have spent a great deal of time in the dissecting-room and that they have completely mastered the temporal bone. A perfect knowledge of the fundamental anatomy of the petrous bone is essential before embarking on the difficult surgical procedures in this region of the brain and base of the skull. Reading this work makes it abundantly clear that the results of this type of sur gery are vastly improved when neurosurgeons and otologists combine their skills. Each of these specialists brings his unique experience and entire knowledge to the operation for the greater benefit of the patient. We wish to congratulate Doctors Pellet, Cannoni and Pech on the publication of this excellent work. March 1990 William F. House, MD William E. Hitselberger, MD Contents Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Basic Anatomy .. 5 The Petrous Pyramid 7 TIle Petrous Cortex 7 Surfaces 8 14 Base ....... .

Modern microsurgical techniques have opened up a new horizon for the otoneurosurgeon. This volume is a very important contribu tion to the student who is learning these surgical approaches. Surgical otoneurology has now passed the infancy stage, but is still an adolescent. As more otologists and neurosurgeons become skilled in this type of surgery, new and better approaches will evolve. Certainly there needs to be much better management of the carotid artery as it passes through the temporal bone. Better techniques to preserve the IX, X, and XI nerves in the jugular bulb area should be developed, and more delicate procedures for management of lesions inside the cochlea and vestibular labyrinth should be developed. As our diagnostic techniques have improved, particularly through imaging, surgical techniques to match the improved diagnostic techniques will emerge. For future otoneurologists who are pre pared, many problems involving the temporal bone that are now considered untreatable will be successfully managed for very grateful patients. The purpose of this text is to familiarize the otoneurosur geon with the anatomy of the temporal bone, skull base, infratem poral fossa, and cerebellopontine angle. This anatomy will be taught by demonstrating surgical procedures. This atlas which is an example of cooperation between the schools of Los Angeles and Verona will permit the reader to rehearse otoneurosurgical procedures in the laboratory, and, when the techniques have been mastered, apply the various approaches in the treatment of inner ear and skull base lesions. William F. House MD.

As an addition to the European postgraduate training system for young neurosurgeons, we began to publish in 1974 this series of Advances and Technical Standards in Neurosurgery which was later sponsored by the European Association of Neurosurgical Societies. This series was first discussed in 1972 at a combined meeting of the Italian and German Neurosurgical Societies in Taormina, the founding fathers of the series being Jean Brihaye, Bernard Pertuiset, Fritz Loew and Hugo Krayenbuhl. Thus were established the principles of European co operation which have been born from the European spirit, flourished in the European Association, and have been associated throughout with this senes. The fact that the English language is now the international medium for communication at European scientificconferences is a great asset in terms of mutual understanding. Therefore we have decided to publish all contri butions in English, regardless of the native language of the authors. All contributions are submitted to the entire editorial board before publication of any volume for scrutiny and suggestions for revision. Our series is not intended to compete with the publications of original scientificpapers in other neurosurgical journals. Our intention is, rather, to present fields of neurosurgery and related areas in which important recent advances have been made. The contributions are written by specialists in the given fieldsand constitute the first part of each volume.

Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer''s disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer''s, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena. Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on OC Metals and the Brain: From Neurochemistry to NeurodegenerationOCO (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa. This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy. Contents: Metal-Catalyzed Redox Activity in Neurodegenerative Disease (M A Taddeo et al.); Aluminum and Central Nervous System Morphology in Hemodialysis (E Reusche); Transition Metals, Oxidation, Lipoproteins, and Amyloid-: Major Players in Alzheimer''s Disease (A Kontush); Molecular Basis of Copper Transport: Cellular and Physiological Functions of Menkes and Wilson Disease Proteins (ATP7A and ATP7B) (D R Kramer et al.); Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis (M B Yim et al.); Copper and Prion Disease (J Sasson & D Brown); Metallothioneins in Neurodegeneration (M Aschner et al.); Iron and Neurodegeneration (S L Grab & J R Connor); Iron, Neuromelanin, and -Synuclein in Neuropathogenesis of Parkinson''s Disease (K L Double et al.); Iron and Epilepsy (W-Y Ong et al.); Role of Iron Metabolism in Multiple Sclerosis (M J Kotze et al.); Neuroprotective Effects of Lithium (S Ermidiou-Pollet & S Pollet); and other articles. Readership: Academics, graduate students and researchers in neurology, psychiatry, neuroscience and environmental health."

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Sixteenth Edition, Seven Volume Set builds on the success of the 15 previous editions, providing an extensively reorganized and expanded resource that now comprises more than 1,500 individual drug articles with the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature, making this a must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company. The online version of the book provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking, and fully downloadable and printable full-text, HTML or PDF articles. Enhanced encyclopedic format with drug monographs now organized alphabetically Completely expanded coverage of each drug, with more than 1,500 drug articles and information on adverse reactions and interactions Clearer, systematic organization of information for easier reading, including case histories to provide perspective on each listing Extensive bibliography with over 40,000 references A must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company