If theoretical physicists can seriously entertain canonical “standard models” even for the big-bang generation of the entire universe, why cannot life scientists reach a consensus on how life has emerged and settled on this planet? Scientists are hindered by conceptual gaps between bottom-up inferences (from early Earth geological conditions) and top-down extrapolations (from modern life forms to common ancestral states). This book challenges several widely held assumptions and argues for alternative approaches instead. Primal syntheses (literally or figuratively speaking) are called for in at least five major areas. (1) The first RNA-like molecules may have been selected by solar light as being exceptionally photostable. (2) Photosynthetically active minerals and reduced phosphorus compounds could have efficiently coupled the persistent natural energy flows to the primordial metabolism. (3) Stochastic, uncoded peptides may have kick-started an ever-tightening co-evolution of proteins and nucleic acids. (4) The living fossils from the primeval RNA World thrive within modern cells. (5) From the inherently complex protocellular associations preceding the consolidation of integral genomes, eukaryotic cell organization may have evolved more naturally than simple prokaryote-like life forms. – If this book can motivate dedicated researchers to further explore the alternative mechanisms presented, it will have served its purpose well.

Conflicting Models for the Origin of Life Conflicting Models for the Origin of Life provides a forum to compare and contrast the many hypotheses that have been put forward to explain the origin of life. There is a revolution brewing in the field of Origin of Life: in the process of trying to figure out how Life started, many researchers believe there is an impending second creation of life, not necessarily biological. Up-to-date understanding is needed to prepare us for the technological, and societal changes it would bring. Schrodinger’s 1944 “What is life?” included the insight of an information carrier, which inspired the discovery of the structure of DNA. In “Conflicting Models of the Origin of Life” a selection of the world’s experts are brought together to cover different aspects of the research: from progress towards synthetic life – artificial cells and sub-cellular components, to new definitions of life and the unexpected places life could (have) emerge(d). Chapters also cover fundamental questions of how memory could emerge from memoryless processes, and how we can tell if a molecule may have emerged from life. Similarly, cutting-edge research discusses plausible reactions for the emergence of life both on Earth and on exoplanets. Additional perspectives from geologists, philosophers and even roboticists thinking about the origin of life round out this volume. The text is a state-of-the-art snapshot of the latest developments on the emergence of life, to be used both in graduate classes and by citizen scientists. Audience Researchers in any area of astrobiology, as well as others interested in the origins of life, will find a modern and current review of the field and the current debates and obstacles. This book will clearly illustrate the current state-of-the-art and engage the imagination and creativity of experts across many disciplines.

This book surveys the models for the origin of life and presents a new model starting with shaped droplets and ending with life as polygonal Archaea; it collects the most published micrographs of Archaea (discovered only in 1977), which support this conclusion, and thus provides the first visual survey of Archaea. Origin of Life via Archaea’s purpose is to add a new hypothesis on what are called “shaped droplets”, as the starting point, for flat, polygonal Archaea, supporting the Vesicles First hypothesis. The book contains over 6000 distinct references and micrographs of 440 extant species of Archaea, 41% of which exhibit polygonal phenotypes. It surveys the intellectual battleground of the many ideas of the origin of life on earth, chemical equilibrium, autocatalysis, and biotic polymers. This book contains 17 chapters, some coauthored, on a wide range of topics on the origin of life, including Archaea’s origin, patterns, and species. It shows how various aspects of the origin of life may have occurred at chemical equilibrium, not requiring an energy source, contrary to the general assumption. For the reader’s value, its compendium of Archaea micrographs might also serve many other interesting questions about Archaea. One chapter presents a theory for the shape of flat, polygonal Archaea in terms of the energetics at the surface, edges and corners of the S-layer. Another shows how membrane peptides may have originated. The book also includes a large table of most extant Archaea, that is searchable in the electronic version. It ends with a chapter on problems needing further research. Audience This book will be used by astrobiologists, origin of life biologists, physicists of small systems, geologists, biochemists, theoretical and vesicle chemists.

Untangling Molecular Biodiversity presents a unique global framework to explain molecular and organismal biodiversity that is grounded in evolutionary genomics. This book will tackle important questions such as the origin of life, the emergence of biochemistry, the origin of viruses, the nature of the last universal common ancestor responsible for diversified life, the role of information and thermodynamics in evolution, the reason for having three cellular domains in life, and the centrality of modules in biology.This book will explore six themes: (1) Explanatory frameworks for biological organization; (2) Evolutionary patterns and biodiversity; (3) Molecular structure and evolutionary genomics; (4) A framework of persistence strategies that borrows from engineering and systems biology; (5) Use of this framework to explain diversity in the molecular world; and (6) Exploring the origin and evolution of cells and viruses.Consequently, this book represents a very unique collection of ideas that can attract the attention of a broad readership interested in life sciences/biology.

Addressing the emergence of life from a systems biology perspective, this new edition has undergone extensive revision, reflecting changes in scientific understanding and evolution of thought on the question 'what is life?'. With an emphasis on the philosophical aspects of science, including the epistemic features of modern synthetic biology, and also providing an updated view of the autopoiesis/cognition theory, the book gives an exhaustive treatment of the biophysical properties of vesicles, seen as the beginning of the 'road map' to the minimal cell - a road map which will develop into the question of whether and to what extent synthetic biology will be capable of making minimal life in the laboratory. Fully illustrated, accessibly written, directly challenging the reader with provocative questions, offering suggestions for research proposals, and including dialogues with contemporary authors such as Humberto Maturana, Albert Eschenmoser and Harold Morowitz, this is an ideal resource for researchers and students across fields including bioengineering, evolutionary biology, molecular biology, chemistry and chemical engineering.

A reconceptualization of origins research that exploits a modern understanding of non-covalent molecular forces that stabilize living prokaryotic cells. Scientific research into the origins of life remains exploratory and speculative. Science has no definitive answer to the biggest questions--"What is life?" and "How did life begin on earth?" In this book, Jan Spitzer reconceptualizes origins research by exploiting a modern understanding of non-covalent molecular forces and covalent bond formation--a physicochemical approach propounded originally by Linus Pauling and Max Delbrück. Spitzer develops the Pauling-Delbrück premise as a physicochemical jigsaw puzzle that identifies key stages in life's emergence, from the formation of first oceans, tidal sediments, and proto-biofilms to progenotes, proto-cells and the first cellular organisms.