Organophosphates Chemistry, Fate, and Effects
Title | Organophosphates Chemistry, Fate, and Effects PDF eBook |
Author | Janice E. Chambers |
Publisher | Elsevier |
Pages | 462 |
Release | 2013-10-22 |
Genre | Medical |
ISBN | 0080917267 |
This volume pulls together a wealth of up-to-date information on the toxicology of this diverse and ubiquitous class of insecticides. Leading experts review the reactivity of organophosphorus compounds with cholinesterase, as well as their metabolism and biological effects on humans and other nontarget organisms. The book not only covers the anticholinesterase actions of organophosphates, but also other, presumably independent, effects, such as teratogenicity, delayed neuropathy, immunotoxicity, and behavioral toxicity. - Offers crucial overviews of chemical and biochemical reactivity and biological responsiveness of mainly nontarget organisms - Reviews new developments in assessment of metabolism and disposition of organophosphorus compounds - Examines organophosphorus compound-induced toxicity mediated by mechanisms other than inhibition of acetylcholinesterase - Covers new research on differences in toxicity induced by the variety of organophosphorus - Analyzes current controversies on the relevance of certain biochemical parameters in actual organophosphate toxicity in vivo
Chemistry and Fate of Organophosphorus Compounds
Title | Chemistry and Fate of Organophosphorus Compounds PDF eBook |
Author | E. Merian |
Publisher | Taylor & Francis |
Pages | 232 |
Release | 1987 |
Genre | Science |
ISBN | 9782881242151 |
First published in 1987. Routledge is an imprint of Taylor & Francis, an informa company.
Toxicology of Organophosphate and Carbamate Compounds
Title | Toxicology of Organophosphate and Carbamate Compounds PDF eBook |
Author | Ramesh C Gupta |
Publisher | Academic Press |
Pages | 781 |
Release | 2011-04-28 |
Genre | Technology & Engineering |
ISBN | 0080543103 |
This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs. In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides. - Describes everything you need to know about Organophosphates and Carbamates - Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants - Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates - Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases - Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity - Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis - Provides in vitro and in vivo models for neurotoxicity testing - Integrates knowledge of studies in lab animals and humans - Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues - Describes management of Anticholinesterase poisoning in humans
Basic and Clinical Toxicology of Organophosphorus Compounds
Title | Basic and Clinical Toxicology of Organophosphorus Compounds PDF eBook |
Author | Mahdi Balali-Mood |
Publisher | Springer Science & Business Media |
Pages | 264 |
Release | 2013-12-19 |
Genre | Medical |
ISBN | 1447156250 |
This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.
Toxic Phosphorus Esters
Title | Toxic Phosphorus Esters PDF eBook |
Author | Richard D. O'Brien |
Publisher | Elsevier |
Pages | 447 |
Release | 2013-10-22 |
Genre | Science |
ISBN | 1483270939 |
Toxic Phosphorus Esters: Chemistry, Metabolism, and Biological Effects aims to become a source book on organophosphate research and show how the understanding of the events following organophosphate poisoning of animals can be understood in terms of events at the molecular level. The manuscript first offers information on nonenzymic reactions and the reaction with cholinesterase in vitro. Discussions focus on hydrolysis, isomerization, oxidation, phosphorylation of the enzyme, and selectivity for different cholinesterases. The text then examines enzymic degradation and activation in vitro, effects in mammals, and effects on isolated whole tissues. The publication ponders on the effects in insects and plants, including results of poisoning, metabolism, resistance, antagonism and synergism, and phytotoxicity. The text also reviews selective toxicity, as well as excretion and storage, metabolism, design of new selective compounds, and nature of the target. The manuscript is a dependable reference for readers interested in the composition, reactions, and effects of toxic phosphorus esters.
The Chemistry of Organophosphorus Pesticides
Title | The Chemistry of Organophosphorus Pesticides PDF eBook |
Author | C. Fest |
Publisher | Springer Science & Business Media |
Pages | 369 |
Release | 2012-12-06 |
Genre | Technology & Engineering |
ISBN | 3642684416 |
Rapid progress in the field of organophosphate compounds has made this new edition necessary. Particular attention has been paid to new developments in biologically active products as this is probably of greatest interest to practical chemists. I have therefore updated the chapter on chemistry and, in connection with this, rewritten the chapter on metabolism. I should especially like to thank Professor Dr. HELLMUT HOFFMANN for his constant encouragement and interest in my work and for many fruitful discus sions. The co-author to the 1st edition, Dr. KARL-JULIUS SCHMIDT, died suddenly on November 21, 1980. I treasure the memory of a valued colleague of many years standing. Elberfeld, January 1982 CHRISTA FEST VII Preface to the First Edition Our intention has been to provide a short introduction to the chemistry and mode of action of insecticidal phosphoric acid compounds, with particular ref erence to the relationship between structure and activity. The yearly produc tion of these pesticides is now approaching 100,000 tons and thus offers an im portant example of applied research. If, however, one examines the historical development of these compounds, it is apparent that this was preceded by a hundred years of pure chemistry of phosphorus.
Quantitative Structure Activity Relationships to Predict the Fate and Effects of Selected Organophosphorus and Carbamate Insecticides in Aquatic Systems
Title | Quantitative Structure Activity Relationships to Predict the Fate and Effects of Selected Organophosphorus and Carbamate Insecticides in Aquatic Systems PDF eBook |
Author | David Brian Kallander |
Publisher | |
Pages | 264 |
Release | 1993 |
Genre | |
ISBN |