This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.

Optical coherence tomography angiography (OCTA) has undergone tremendous growth since its first commercial introduction in 2014. Because it provides injection-free, capillary-resolution, 3-dimensional angiography of the retina and choroid, OCTA is likely to overtake fluorescein as the most important angiographic imaging technique in the eye. Nearly all manufacturers of ophthalmic OCT now offer OCTA products. A PubMed search now yields over 5700 articles on OCTA and related terms. Clinical investigators have already found a use for OCTA in almost every category of retinal and optic nerve diseases. This book is meant to bring together all this information so clinicians can have one authoritative text to turn to as we begin to use this new imaging modality that was never taught when we were in formal training. Table of contents Introduction Dedication About the Editors Contributors 1. Optical coherence tomography systems for angiography 2. Optical coherence tomographic angiography algorithms 3. Vascular anatomy of the normal retina and choroid 4. OCTA of the normal anterior eye circulations 5. Artifacts 6. Quantification 7. Artificial intelligence in optical coherence tomographic angiography 8. Terminology: a new standard 9. AngioVue SSADA OCTA on the Optovue SOLIX Spectral-Domain OCT 10. Optical microangiography with AngioPlex® and PLEX® Elite systems 11. Optical coherence tomography angiography imaging on the Topcon Triton and Maestro2 systems 12. NIDEK Mirante OCT angiography 13. OCTA on the Heidelberg spectralis spectral-domain OCT 14. OCTA on the Optopol REVO NX spectral-domain OCT 15. OCTA on the Canon OCT-HS100 and Xephilio OCT-A1 Spectral-Domain OCT 16. Exudative neovascular age-related macular degeneration—Type 1, 2 and 3 neovascularization 17. Retinal angiomatous proliferation—type 3 choroidal neovascularization 18. Short- and long-term follow-up of macular neovascularization response to antiangiogenic treatment 19. Nonexudative neovascular age-related macular degeneration 20. Non-neovascular age-related macular degeneration 21. Polypoidal choroidal vasculopathy 22. Macular telangiectasia 23. Central serous chorioretinopathy 25. Nonproliferative diabetic retinopathy 26. Subclinical neovascular diabetic retinopathy 27. Proliferative diabetic retinopathy 28. Retinal venous occlusion 29. Retinal arterial occlusion 30. Plexus-specific occlusions in retinal vascular diseases 31. Paracentral acute middle maculopathy 32. Inherited retinal degenerations 33. Pathologic myopia 34. Multimodal imaging and the role of optical coherence tomography angiography in retinal vasculitis 35. White spot syndromes 36. Choroidal tumors 37. Radiation retinopathy 38. Open-angle glaucoma 39. Primary angle-closure glaucoma 40. Optic neuritis and multiple sclerosis 41. Alzheimer’s disease 42. Corneal neovascularization 43. Ocular surface and iris tumors

This handbook provides ophthalmologists and trainees with the latest advances in the rapidly developing field of OCT Angiography. Beginning with an overview of the technology and terminology, the next chapter explains how to perform an OCTA examination. The following sections describe the pathophysiology, clinical features, imaging and management techniques for different retinal disorders. Authored by an internationally recognised group of experts, led by Professor Bruno Lumbroso, the book is highly illustrated with cross sectional and ‘en face’ OCT images, drawings and tables. This text is invaluable reading for clinicians learning OCTA interpretation for routine everyday use and diagnostic retinal pathologies. Key points Presents latest advances in field of OCT Angiography Covers pathophysiology, clinical features, imaging and management techniques for different retinal disorders Highly illustrated with cross sectional and ‘en face’ OCT images, drawings and tables Internationally recognised author team led by renowned Professor Bruno Lumbroso

"The recent introduction of optical coherence tomography angiography (OCTA) has remarkably expanded our knowledge of different retinal, chorioretinal, and optic disc disorders. OCTA is nowadays often introduced as a routine exam in clinical practice, granting the opportunity to non-invasively investigate retinal and choroidal circulation. In this book, many major experts in posterior eye imaging share their experiences and their latest images and ideas about OCTA"--

Highly visual and easy to navigate, OCT and OCT Angiography in Retinal Disorders is a concise, reliable reference for optical coherence tomography (OCT) and OCT angiography findings in both common and uncommon retinal disorders. Each chapter explores the prognostic features of OCT and OCTA scans along with additional diagnostic modalities for comparison and correlation. Where appropriate, longitudinal changes in response to treatment or natural history are also discussed.

Optical coherence tomography angiography (OCTA) is a non-invasive technique for imaging the microvasculature of the retina and the choroid. The advent of OCTA has allowed ophthalmologists to identify new pathologies, recognise new syndromes, and organise disorders with new classifications. This atlas provides clinicians with state-of-the-art principles of clinical OCTA imaging, helping them interpret and understand the features of the angiographic images. Following the success of the first edition (9789351528999) published in 2015, this second edition has been fully revised, with all chapters rewritten and new topics added to provide the very latest advances in the field. New knowledge about existing diseases and new disorders are described in depth, and operating principles, clinical applications, and future developments are explained thoroughly by the pioneers of the technology. The first part of the atlas covers the basic principles of OCT angiography, methods and technology, image interpretation, vascular anatomy of the retina, and clinical applications. Part two provides a general update on current research into OCT angiography in various retinal, choroid and anterior chamber disorders. The third and final part of the book describes future clinical applications and implications of next generation devices. This new edition is an invaluable guide for ophthalmologists and trainees for use in everyday practice.

This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.