Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.

This book presents two analyses, the first of which involves the search for a new heavy charged gauge boson, a so-called W' boson. This new gauge boson is predicted by some theories extending the Standard Model gauge group to solve some of its conceptual problems. Decays of the W' boson in final states with a lepton (l± = e± , μ±) and the corresponding (anti-)neutrino are considered. Data collected by the ATLAS experiment in 2015 at a center of mass energy of √s =13 TeV is used for the analysis. In turn, the second analysis presents a measurement of the double-differential cross section of the process pp->Z/gamma^* + X -> l^+l^- + X, including a gamma gamma induced contribution, at a center of mass energy of sqrt{s} = 8 TeV. The measurement is performed in an invariant mass region of 116 GeV to 1500 GeV as a function of invariant mass and absolute rapidity of the l^+l^-- pair, and as a function of invariant mass and pseudorapidity separation of the l^+l^-- pair. The data analyzed was recorded by the ATLAS experiment in 2012 and corresponds to an integrated luminosity of 20.3/fb. It is expected that the measured cross sections are sensitive to the PDFs at very high values of the Bjorken-x scaling variable, and to the photon structure of the proton.

The Black Book of Quantum Chromodynamics is an in-depth introduction to the particle physics of current and future experiments at particle accelerators. The book offers the reader an overview of practically all aspects of the strong interaction necessary to understand and appreciate modern particle phenomenology at the energy frontier. It assumes a working knowledge of quantum field theory at the level of introductory textbooks used for advanced undergraduate or in standard postgraduate lectures. The book expands this knowledge with an intuitive understanding of relevant physical concepts, an introduction to modern techniques, and their application to the phenomenology of the strong interaction at the highest energies. Aimed at graduate students and researchers, it also serves as a comprehensive reference for LHC experimenters and theorists. This book offers an exhaustive presentation of the technologies developed and used by practitioners in the field of fixed-order perturbation theory and an overview of results relevant for the ongoing research programme at the LHC. It includes an in-depth description of various analytic resummation techniques, which form the basis for our understanding of the QCD radiation pattern and how strong production processes manifest themselves in data, and a concise discussion of numerical resummation through parton showers, which form the basis of event generators for the simulation of LHC physics, and their matching and merging with fixed-order matrix elements. It also gives a detailed presentation of the physics behind the parton distribution functions, which are a necessary ingredient for every calculation relevant for physics at hadron colliders such as the LHC, and an introduction to non-perturbative aspects of the strong interaction, including inclusive observables such as total and elastic cross sections, and non-trivial effects such as multiple parton interactions and hadronization. The book concludes with a useful overview contextualising data from previous experiments such as the Tevatron and the Run I of the LHC which have shaped our understanding of QCD at hadron colliders.

This concise primer reviews the latest developments in the field of jets. Jets are collinear sprays of hadrons produced in very high-energy collisions, e.g. at the LHC or at a future hadron collider. They are essential to and ubiquitous in experimental analyses, making their study crucial. At present LHC energies and beyond, massive particles around the electroweak scale are frequently produced with transverse momenta that are much larger than their mass, i.e., boosted. The decay products of such boosted massive objects tend to occupy only a relatively small and confined area of the detector and are observed as a single jet. Jets hence arise from many different sources and it is important to be able to distinguish the rare events with boosted resonances from the large backgrounds originating from Quantum Chromodynamics (QCD). This requires familiarity with the internal properties of jets, such as their different radiation patterns, a field broadly known as jet substructure. This set of notes begins by providing a phenomenological motivation, explaining why the study of jets and their substructure is of particular importance for the current and future program of the LHC, followed by a brief but insightful introduction to QCD and to hadron-collider phenomenology. The next section introduces jets as complex objects constructed from a sequential recombination algorithm. In this context some experimental aspects are also reviewed. Since jet substructure calculations are multi-scale problems that call for all-order treatments (resummations), the bases of such calculations are discussed for simple jet quantities. With these QCD and jet physics ingredients in hand, readers can then dig into jet substructure itself. Accordingly, these notes first highlight the main concepts behind substructure techniques and introduce a list of the main jet substructure tools that have been used over the past decade. Analytic calculations are then provided for several families of tools, the goal being to identify their key characteristics. In closing, the book provides an overview of LHC searches and measurements where jet substructure techniques are used, reviews the main take-home messages, and outlines future perspectives.

Describes the branch of astronomy in which processes in the universe are investigated with experimental methods employed in particle-physics experiments. After a historical introduction the basics of elementary particles, Explains particle interactions and the relevant detection techniques, while modern aspects of astroparticle physics are described in a chapter on cosmology. Provides an orientation in the field of astroparticle physics that many beginners might seek and appreciate because the underlying physics fundamentals are presented with little mathematics, and the results are illustrated by many diagrams. Readers have a chance to enter this field of astronomy with a book that closes the gap between expert and popular level.

The Higgs Hunter's Guide is a definitive and comprehensive guide to the physics of Higgs bosons. In particular, it discusses the extended Higgs sectors required by those recent theoretical approaches that go beyond the Standard Model, including supersymmetry and superstring-inspired models.

Quantum physics may appear complicated, especially if one forgets the "big picture" and gets lost in the details. However, it can become clearer and less tangled if one applies a few fundamental concepts so that simplified approaches can emerge and estimated orders of magnitude become clear. Povh and Rosina’s Scattering and Structures presents the properties of quantum systems (elementary particles, nucleons, atoms, molecules, quantum gases, quantum liquids, stars, and early universe) with the help of elementary concepts and analogies between these seemingly different systems. In this new edition, sections on quantum gases and an up to date overview of elementary particles have been added.