The mechanisms of release of insulin in response to the body's intake of nutrients has long been one of the central problems of research into diabetes. This book presents the latest findings on the topic from the leading laboratories in the field.

Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control. Part One of the book provides general coverage of nutrition and diabetes in terms of dietary patterns, insulin resistance, and the glucose-insulin axis, while Part Two presents the molecular biology of diabetes and focuses on areas such as oxidative stress, mitochondrial function, insulin resistance, high-fat diets, nutriceuticals, and lipid accumulation. Final sections explore the genetic machinery behind diabetes and diabetic metabolism, including signaling pathways, gene expression, genome-wide association studies, and specific gene expression. While the main focus of each chapter is the basic and clinical research on diabetes as a nutritional problem, all chapters also end with a translational section on the implications for the nutritional control of diabetes. Offers updated information and a perspective on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of diabetes mellitus Explores how nutritional factors are involved in the pathogenesis of both type1 and type2 diabetes and their complications Investigates the molecular and genetic bases of diabetes and diabetic metabolism through the lens of a rapidly evolving field of molecular nutrition

More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.

Metabolic Regulation looks in detail at how molecules, cells and tissues operate collectively in human health and disease, using an approach that has become known as ‘integrative physiology’. Since the publication of the first edition of this extremely well received book, the understanding of how metabolism is regulated has developed substantially in several ways, for example with the discovery of the hormone leptin, and also in the continuing advances in the understanding of gene expression. Full details of these and other new advances are included in this fully updated edition. Carefully laid out with relevant and clearly explained examples, and containing much new material, this new edition covers in an integrated way: concepts and mechanisms, digestion and intestinal absorption, organs and tissues, endocrine organs and hormones, the integration of carbohydrate, fat and protein metabolism, the nervous system and metabolism, lipoprotein metabolism, diabetes mellitus, energy balance and body weight regulation and how the body copes with some extreme situations. The author, Keith Frayn, who has many years’ experience teaching and researching in this subject, has written a book of great clarity, which is an extremely valuable tool for scientists, practitioners and students working and studying across a broad range of allied health sciences including nutrition, dietetics, sports science and nursing. Students of medicine, physiology, biochemistry and biological sciences will also find much of great use and interest in this book. All libraries in research establishments, universities and medical schools where these subjects are studied and taught should have multiple copies of this excellent book on their shelves. Keith Frayn is Professor of Human Metabolism at the University of Oxford, UK.Reviews of the First Edition ‘This is an excellent textbook’: Trends in Endocrinology and Metabolism ‘The coverage is excellent for students following courses such as nutrition and human biology’:Biologist ‘This book is ideal for medical students’:Australian Society for Biochemistry and Molecular Biology

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on the pancreatic beta cell. Expertise of the contributors Coverage of a vast array of subjects In depth current information at the molecular to the clinical levels Three-dimensional structures in color Elaborate signaling pathways