In this issue of Clinics in Chest Medicine, Guest Editors Harold R Collard, Luca Richeldi, and Kerri A. Johannson bring their considerable expertise to the topic of Next-generation Interstitial Lung Disease. Provides concise and comprehensive coverage of the issues physicians face every day. Presents the latest information on a timely, focused topic under the leadership of experienced editors in the field.

In this issue of Clinics in Chest Medicine, Guest Editors Harold R Collard, Luca Richeldi, and Kerri A. Johannson bring their considerable expertise to the topic of Next-generation Interstitial Lung Disease. Provides concise and comprehensive coverage of the issues physicians face every day. Presents the latest information on a timely, focused topic under the leadership of experienced editors in the field.

This issue of Clinics in Chest Medicine, guest-edited by Dr. Aaron B Waxman and Dr. Inderjit Singh, is focused on Pulmonary Hypertension. Topics discussed in this issue include but are not limited to: Integrative omics to characterize and classify pulmonary vascular disease, Contemporary Pharmacotherapeutic Approach in Pulmonary Arterial Hypertension, Personalized Medicine: The Future Management of Pulmonary Hypertension Requires A New Taxonomy, Sex differences in Pulmonary Hypertension and Pulmonary Hypertension in Pregnancy

This issue of Clinics in Chest Medicine, guest-edited by Drs. Carrie A. Redlich, Kristin J. Cummings, and Peggy Lai, is focused on Advances in Occupational and Environmental Lung Diseases. Topics discussed in this issue include but are not limited to: Master Clinician – selected occupational and environmental pulmonary cases; Chest imaging in the Diagnosis of Occupational Lung Diseases; Harnessing electronic medical records to enhance the diagnosis of work-related lung diseases; The impact of health disparities on lung disease; Respiratory health effects of exposure to cleaning products; Occupational upper airways disorders, including laryngeal dysfunction; Occupational bronchiolitis – including flavoring-related lung disease, deployment; Coal workers pneumoconiosis and other mining-related lung disease: the re-emergence of an old disease (including COPD in miners); Occupational contributions to ILD (including asbestos, overlap HP and ILD); Silicosis – Persistence of an old disease, old and new exposure settings and prevention; Occupational respiratory cancer: Chest CT screening; Occupational respiratory Infections: pneumonia, healthcare workers; Update on climate change: its impact on respiratory health at work, home, and at play; The changing nature of wildfires: update on the respiratory health of first responders and communities; The microbiome and damp Indoor environments; The on-going impact of World Trade Center exposures on respiratory health; The impact of Electronic cigarettes and smoking cessation; The respiratory risks of ambient /outdoor air pollution; and Indoor air pollution and respiratory health.

This issue of Clinics in Chest Medicine focuses on Viral and Atypical Pneumonia. Editors Charles Dela Cruz and Richard Wunderlink have assembled an expert team of authors on topics such as: Epidemiology of Viral Pneumonia; Diagnostic Testing for Viral and Atypical Infections;Lung Microbiome: Atypical Infections and Viruses; RSV Pneumonia in the Young and Old;Viral infections in Chronic Lung Diseases; Viral Pneumonia and ARDS;Viruses in the Immunocompromised; Atypical Bacterial Pneumonia; Other Community Respiratory Viruses; Pandemic Viruses; Epidemic and Emerging Coronaviruses; Post-Viral Complications; Antiviral Treatments; and Vaccines in the Prevention of Viral Pneumonia.

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

The guest editors for this issue, Talmadge King, Harold Collard, celebrated pulmonary specialists from UCSF, and Luca Richeldi, renowned visiting professor to UCSF from University of Modena, Italy, bring together a state-of-the-art issue on the important topic of Interstitial Lung Diseases (ILD). This comprehensive issue reviews the approach to diagnosis of ILD, radiology if ILD, pathology of ILD. Idiopathic pulmonary fibrosis is discussed, including phenotypes and comorbidities, acute exacerbation and accelerated decline, management, and pathobiology of novel approaches to therapy. Connective Tissue ILD, Chronic Hypersensitivity Pneumonitis, familial ILD and smoking-related ILD, and non-specific interstitial pneumonia are reviewed. In the final article, lung transplantation is discussed.