Development of the brain and the emergence of the mind constitute some of the most important concerns of contemporary biology. Disturbances during fetal life may have profound implications for a child's future neurological and psychological development, which can in turn impact society. The new edition of this highly respected work presents a comprehensive review of the basic mechanisms of brain development and the pathophysiology of disorders of the infant brain, written by a team of distinguished neuroscientists, neonatologists, and neuropediatricians. The book follows the main milestones of brain development, from formation of the neural tube and wiring of the neurons in the brain. Neurotrophic factors, neurotransmitters, glial cell biology, cerebral circulation development of sensory functions are all described in detail. Furthermore, there are more philosophical chapters on the evolution of the brain and the emergence of consciousness. Clinical considerations are highlighted where relevant.

A complete update of the highly acclaimed handbook with data on all neurotransmitters and the majority of neuromodulators. The coverage is now even more comprehensive, with 15% more entries on neuropeptides, "classic" neurotransmitters and related substances in a clear, alphabetical format. The methodological section has been expanded by 50% and now includes color figures, plus new chapters on genomics, proteomics, databases, microarrays, MALDI-TOF, neutrophins, FGF, endocannabinoids and neuroimaging. The text provides clearly structured information on the biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system, with all substances uniformly treated for an easy comparison of data. Furthermore, introductory chapters on receptors, transporters, and the blood-brain barrier make this an indispensable tool for researchers, teachers, and advanced students, as well as a must-have for every neuroscientist.

The series CNS Neurotransmitters and Neuromodulators is destined to be the definitive reference work on the physiology and pharmacology of the central nervous system. Written by an outstanding group of international authors, chapters cover a wide range of interdisciplinary aspects of the subject. This first volume includes an in-depth examination of acetylcholine, ranging from the localization of synthetic enzymes through electrophysiology, pharmacology, and molecular biology to behavioral importance in learning and memory. This indispensable and comprehensive reference keeps you abreast of new developments in several areas of neuroscience.

This book is a result of a Symposium* organized by the Editors in October 1984 at San Diego. Almost all of the present and past investigators of the Crustacean Stomatogastric Nervous Systems participated. However, this book should not, by any means, be considered a sympo sium report. Its goal is to present not only the most recent results obtained with this system, but also a complete and comprehensive view of the con tributions made by this preparation to fundamental concepts in neurobiol ogy. This has been possible only with the cooperation of all of the investiga tors concerned and we must gratefully thank all of our colleagues who have agreed to let the authors of the chapters include some unpublished results. Short appendices have been added to several chapters to clarify some key points which are still unpublished or to illustrate briefly some recent promis ing new findings. We would also like to acknowledge as a whole the many journals which have permitted us to reproduce some Original figures. Maurice Moulins and Allen I. Selverston * Supported by the National Science Foundation and the Centre National de la Re cherche Scientifique. Contents Introduction. M. Moulins and A.1. Selverston. (With 4 Figures) . . . . . 1 1 Functional Anatomy and Behavior. B.J. Claiborne and J. Ayers (With 11 Figures). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 1.1 Functional Anatomy . . . . . . . . . . . . . . . . . . . .. . . 9 . . . . . 1.1.1 Ossicles.. . . . . . . . . . . . . . . . . . . . . . .. . . . 9 . . . . . 1.1.2 Musculature . . . . . . . . . . . . . . . . . . . . .. . . 11 . . . . . . 1.1.3 Nervous System . . . . . . . . . . . . . . . . . . .. . . 13 . . . . .

This volume is one of those published from the proceedings of the invited lectures to the First International Congress of Comparative Physiology and Biochemistry I organized at Liege (Belgium) in August 1984 under the auspices of the Section of Comparative Physiology and Biochemistry of the International Union of Biological Sciences. In a general foreword to these different volumes, it seems to me appropriate to consider briefly what may be the comparative approach. Living organisms, beyond the diversity of their morphological forms, have evolved a widespread range of basic solutions to cope with the different problems, both organismal and environmental with which they are faced. Soon after the turn of the century, some biologists realized that these solutions can be best comprehended in the frame work of a comparative approach integrating results of physiological and biochemical studies done at the organismic, cellular and molecular levels. The development of this approach amongst both physiologists and biochemists remained, however, extremely slow until recently.

It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.

Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.