Excerpt from National Cancer Institute, Office of the Director Annual Report, 1989 Prepared two case studies on health care cost savings resulting from nci supported applied research and clinical trials for use by nih Director and others. Cost savings for cisplatin chemotherapy use in testicular cancer were detailed in one report, while the second report estimated savings derived from early detection of melanoma. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.

Excerpt from National Cancer Institute Annual Report, Vol. 1: October 1, 1988 Through September 30, 1989 CM-09283-05 Control of Human interferon-gamma Gene Expression CM-09303-03 Drug Resistance in Cancer Cells. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.

Excerpt from National Cancer Institute Annual Report, Vol. 1: October 1, 1986 Through September 30, 1987 Various compounds showing promise against the aids virus are being system atically investigated to obtain structural and electronic properties which may help elucidate the mechanism of their action and thus lead to improved analogs. The x-ray structures of -dideoxyadenosine (dda) and -dideoxycytidine (ddc) have been determined. Strain energies and quantum calculations have been carried out on these compounds. Calculations have been completed on the eight possible epimers of 3'-azido - dideoxy thymidine (azt), as well as the corresponding bases: cytidine, adenosine, inosine, 2'-deoxycytidine and 3'-amino-3'-deoxyadenosine for comparison. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.

Excerpt from National Cancer Institute, Office of the Director: 1984 Annual Report; October 1, 1983 September 30, 1984 The functions of the Office of the Associate Director can best be described as those which involve scientific coordination among scientific divisions of the National Cancer Institute. The formation and rearrangement of scientific units, the incorporation of new developments in science into intramural management structures, and the general consideration of contract support for intramural research are of major concern. The Frederick Cancer Research Facility system of research and support contracts is a major responsibility. Coordination of intramural science also extends to the questions of outside activities and the determination of patent status rights in derivative inventions. Several major areas of activity took place in the past year. These blended basic science expertise in various segments of cancer research to effect major intramural scientific decisions. In general, two major types of events are influenced and modified by the Associate Director. The first is the formation or restructuring of basic science laboratories. This has occurred and is occurring with all Divisions. Close advisory and consulting activity with the Director and Division Directors is mandatory. Eventually a concensus option is reached relative to the final proposed laboratory structure. This is discussed and decided upon by the Executive Committee. The second element involves inter-laboratory, inter-divisional cooperation on timely topics, usually in breakthrough areas of science. At times, these interactions are intense but not structured. Areas of key national importance may be considered. Close input occurs on a regular basis by pertinent intramural personnel as well as by members of the NCI advisory bodies. The information is transmitted to the Director, NCI, on an ongoing basis, because he makes the final decisions in the areas of dramatic scientific paradigm changes. The commitment of the Institute to new activities results from this input. A major activity of the past year has been the potential acquisition of the first supercomputer to be dedicated to biomedicine. A reformulation of the Laboratory of Molecular Biology in DCBD was to take place around advanced computing capabilities. In a series of input meetings it became apparent that there is a present and ever-increasing need for supercomputing in several areas of cancer research. The office of the Associate Director collaborated closely with DCBD in selecting a new Laboratory Chief and the acquisition of the instrumentation as well as its support. The location at the FCRF, and the structuring of the operation within NCI's large technical and support contract, was considered to be the most expeditious and advantageous solution. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.

Excerpt from National Cancer Institute Annual Report, Vol. 2: October 1, 1986 Through September 30, 1987 About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.

Excerpt from National Cancer Institute, Annual Report, Vol. 1: October 1, 1977 Through September 30, 1978; Office of the Director No program level changes are anticipated in the Division of Cancer Control and Rehabilitation (dccr). About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.