Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

Pesticide resistance has had a substantial impact on crop production and has been an important driver of change in modern agriculture, animal production and human health. Due to increased selection pressure, this resistance can be linked to export/import health and phytosanitary standards, invasive species eradication projects and global pandemics. However, the development of new biological and chemical products and the use of integrated pest management strategies have been successful in reducing pesticide resistance. Focusing specifically on arthropods, this book provides a comprehensive review of relevant issues in pesticide resistance. Detailed listings and references to all documented reports of resistance from around the world are included as well as discussions on the mechanisms and evolution of resistance and management techniques.

This book contains 20 chapters, which are divided into 5 sections. Section 1 covers different aspects of insecticide resistance of selected economically important plant insect pests, whereas section 2 includes chapters about the importance, development and insecticide resistance management in controlling malaria vectors. Section 3 is dedicated to some general questions in insecticide resistance, while the main topic of section 4 is biochemical approaches of insecticide resistance mechanisms. Section 5 covers ecologically acceptable approaches for overcoming insecticide resistance, such are the use of mycoinsecticides, and understanding the role of some plant chemical compounds, which are important in interactions between plants, their pests and biological control agents.

For over 160 years, pyrethrum has been safely and effectively used as a pesticide the world over. The flowers of this daisy, which contain a mixture of pleasant-smelling esters called the pyrethrins, have highly unusual insecticidal properties. Unique in their ability to repel most insect pests while posing virtually no threat to the environment, pyrethrins have been the subject of great interest to a wide variety of scientists. This book presents for the first time in over twenty years an in-depth look at the many issues surrounding the use of pyrethrins. John E. Casida, a world-renowned authority on the subject, has assembled a group of distinguished contributors to discuss topics ranging from the relationship between pyrethrum and synthetic pyrethroids to cultivation to metabolism to mammalian and environmental toxicology. Along the way, the history of pyrethrum flowers and pyrethrins, the chemistry of active pyrethrin ingredients, the mode of action and resistance, the control of pests, and residues and tolerances are also expertly treated. As safety aspects of pesticides are reevaluated with regard to current regulatory, social, and political implications, pyrethrum has increasingly been seen as the prototype for safe, natural pesticides. Engaging and profusely illustrated, Pyrethrum Flowers is the perfect introduction to the most important natural botanical pesticide. It will appeal to all scientists concerned with pesticides, including botanists, geneticists, biochemists, entomologists, and ecologists.

**The instant New York Times bestseller.** *An international bestseller.* Finalist for the Lane Anderson Award Finalist for the RBC Taylor Award “Hugely impressive, a major work.”—NPR A pioneering and groundbreaking work of narrative nonfiction that offers a dramatic new perspective on the history of humankind, showing how through millennia, the mosquito has been the single most powerful force in determining humanity’s fate Why was gin and tonic the cocktail of choice for British colonists in India and Africa? What does Starbucks have to thank for its global domination? What has protected the lives of popes for millennia? Why did Scotland surrender its sovereignty to England? What was George Washington's secret weapon during the American Revolution? The answer to all these questions, and many more, is the mosquito. Across our planet since the dawn of humankind, this nefarious pest, roughly the size and weight of a grape seed, has been at the frontlines of history as the grim reaper, the harvester of human populations, and the ultimate agent of historical change. As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power. The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village. Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable. Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito’s reign through human history and her indelible impact on our modern world order.

Bruce E. Tabashnik and Richard T. Roush Pesticide resistance is an increasingly urgent worldwide problem. Resistance to one or more pesticides has been documented in more than 440 species of insects and mites. Resistance in vectors of human dise8se, particularly malaria-transmit ting mosquitoes, is a serious threat to public health in many nations. Agricultural productivity is jeopardized because of widespread resistance in crop and livestock pests. Serious resistance problems are also evident in pests of the urban environ ment, most notably cockroaches. Better understanding of pesticide resistance is needed to devise techniques for managing resistance (Le. , slowing, preventing, or reversing development of resistance in pests and promoting it in beneficial natural enemies). At the same time, resistance is a dramatic example of evolution. Knowledge of resistance can thus provide fundamental insights into evolution, genetics, physiology, and ecology. Resistance management can help to reduce the harmful effects of pesticides by decreasing rates of pesticide use and prolonging the efficacy of environmentally safe pesticides. In response to resistance problems, the concentration or frequency of pesticide applications is often increased. Effective resistance management would reduce this type of increased pesticide use. Improved monitoring of resis tance would also decrease the number of ineffective pesticide applications that are made when a resistance problem exists but has not been diagnosed. Resistance often leads to replacement of one pesticide with another that is more expensive and less compatible with alternative controls.