Since the middle of the last century we have progressively built up a comprehensive descriptive model of the allied mechanisms that maintain our muscles at a size and strength appropriate to the functional demands upon them and that rapidly repair damaged muscles. This volume is an assemblage of the collective experience from the pick of major research groups investigating these aspects of muscle cell biology. It provides up-to-date coverage and presents a broad range of topics.

This volume focuses on the cell biology and physiology of skeletal muscle regeneration. This Book is a collection of classic and cutting edge protocols optimized for mice, but in most cases adaptable to rat or other mammalian models, that will allow an investigator to develop and implement a research study on skeletal muscle regeneration. Chapters address the three major areas of study: provoking regeneration by inducing damage to muscle, analyzing the progenitor cells of skeletal muscle, and quantifying overall muscle function. Subjects discussed include: inducing skeletal muscle injury by eccentric contraction; volumetric muscle loss; single myofiber isolation and culture; satellite cell transplantation; muscle clearing for whole mount immunostaining; luciferase tracking of muscle stem cells; mitochondrial and mitophagy flux analysis; in vivo assessment of muscle contractility; force measurements on single isolated myofibers; and analysis of aerobic respiration in intact skeletal muscle tissue by microplate respirometry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to each respective topic, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and practical, Skeletal Muscle Regeneration in the Mouse: Methods and Protocols is an essential laboratory reference for research in skeletal muscle growth, damage, repair, degeneration, and regenerative therapy in the mouse model system.

The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.

It was a long and troublesome history but an inspiring and excltmg one too-from the time of Zielonko, a Russian pathologist who in 1874 first transplanted muscles, to the present day microneurovascular muscle graft. Today we know that for functional recovery of muscle tissue vascularisation and neurotisation are of equal importance. With the establishment of microsurgery of small vessels and nerves, its application for myopias tic operations has gained increasing interest. It was my intention to bring together leading authorities from all over the world in the field of muscle transplantation. Open questions and unsolved problems had to be discussed between research workers in the basic medical sciences and our clinical colleagues; in this way progress can best be accomplished. This publication is the result of the "Vienna Muscle Symposium" (June 13-14, 1980). It gives an up-to-date viewpoint and should act as a stimulus to all who are interested in this particular field. I wish to express my sincere thanks to those who have contributed to this publication, to the two co-editors J. Holle and B. M. Carlson for their effective cooperation, and to Springer-Verlag Wien for their prompt and most efficient work.

Muscle Biology: The Life History of a Muscle looks at the story of a muscle from its embryonic beginnings, through its growth and ability to adapt to changing functional circumstances during adult life, to its eventual decline in both structure and function as old age progresses. Injury occurs to muscle during normal activity, after trauma, and during the source of certain diseases. Chapters on both muscle regeneration and muscle diseases emphasize the possibilities and limitsations of the healing capacity of muscle fibers. Muscle Biology begins with a brief review about the structure and function of a normal mature muscle and then proceeds to follow the developmental history of a muscle from the embryo to old age in a manner that gives the reader a perspective about not only developmental controls but also how at any stage of development a muscle is able to adapt to its functional environment. The book discusses both normal and abnormal changes in the muscle, the mechanisms behind those changes and how to mitigate deleterious changes from disease, 'normal' aging, and disuse/lack of physical activity. This is a must-have reference for students, researchers and practitioners in need of a comprehensive overview of muscle biology. - Provides an overview of muscle biology over the course of one's entire lifespan - Explains the important elements of each aspect of muscle biology without drowning the reader in excessive detail - Contains over 300 illustrations and includes chapter summaries

Providing valuable insights into an element of European nationalism and modernist culture, this book explores the development of the 'Zionist body' as opposed to the traditional stereotype of the physically weak, intellectual Jew. It charts the cultural and intellectual history showing how the 'Muscle Jew' developed as a political symbol of national regeneration.