In this issue of Neuroimaging Clinics, guest editors Drs. Frederik Barkhof and Yaou Liu bring their considerable expertise to the topic of Multiple Sclerosis and Associated Demyelinating Disorders. Top experts in the field discuss advanced brain imaging in CNS demyelinating diseases; new imaging markers in MS and related disorders: smoldering inflammation and central vein sign; the use of AI in MS and white matter disease; optic nerve imaging in MS and related disorders; atypical demyelinating disorders; and more. Co-Editor Frederik Barkhof, MD, has received the National Multiple Sclerosis Society and the American Academy of Neurology's 2018 John Dystel Prize for Multiple Sclerosis Research for his many years of outstanding research in the field of MS, especially in advancing the understanding and clinical use of brain imaging. - Contains 12 relevant, practice-oriented topics including diagnostic criteria for MS, NMOSD and MOGAD; routine MRI protocol and standardization in CNS demyelinating diseases; spinal cord imaging in MS and related disorders; treatment monitoring in MS: efficacy and safety; cognitive impairment in MS and related disorders; and more. - Provides in-depth clinical reviews on multiple sclerosis and associated demyelinating disorders, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue reviews the state of the art in pediatric demyelinating diseases. Articles cover topics on childhood transverse myelitis, neuromyelitis optica, multiple sclerosis, acute demyelinating encephalopathy, and more.

Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.

This issue of Neuroimaging Clinics focuses on Evidence-Based Vascular Neuroimaging and is edited by Drs. Ajay Malhotra and Dheeraj Gandhi. Articles will include: Unruptured Intracranial Aneurysms: Duration, Frequency and Modality Used for Surveillance; Vasospasm: Role of Imaging in Detection and Monitoring Treatment; Extracranial Vascular Disease: Carotid Stenosis and Plaque Imaging; Subarachnoid Hemorrhage: Distribution and Role of Imaging; Acute Ischemic Stroke: MRI-based Paradigms; Imaging of Intracranial Hemorrhage (Non-subarachnoid Hemorrhage); Brain Arteriovenous Malformations: The Role of Imaging in Treatment Planning and Monitoring Response; Intracranial Vascular Disease and Vessel Wall Imaging; Acute Ischemic Stroke: CT/CTA/CTP and Their Role; Imaging for Treated Aneurysms (including clipping, coiling, stents, flow-diverters); and more!

This issue of Neuroimaging Clinics of North America focuses on Imaging of Multiple Sclerosis: Diagnosis and Management, and is edited by Dr. Àlex Rovira Cañellas. Articles will include: Multiple Sclerosis: Epidemiological, Clinical and Therapeutic Aspects; Brain and Spinal Cord MR Imaging Features in Multiple Sclerosis and Variants; Neuromyelitis Optica Spectrum Disorders; Radiologically Isolated Syndrome; MRI in Monitoring and Predicting Treatment Response in Multiple Sclerosis; Cortical Grey Matter MR Imaging in Multiple Sclerosis; Brain Atrophy in Multiple Sclerosis: Technical Aspects and Clinical Relevance; Iron Mapping in Multiple Sclerosis; Microstructural MR Techniques in Multiple Sclerosis; Molecular and Metabolic Imaging in Multiple Sclerosis; Insights from Ultra-high Field Imaging in Multiple Sclerosis; Pediatric Multiple Sclerosis: Distinguishing Clinical and MRI Features, and more!

Multiple sclerosis (MS) is an immune-mediated neurodegenerative disorder of the human central nervous system (CNS) which usually affects young adults with certain genetic backgrounds who are then exposed to certain precipitating environmental antigen(s). Despite major advances of the past two decades in understanding the pathophysiology of MS, and in spite of the introduction of new immunomodulatory and immuno-suppressive agents which may slow down disease progression and delay the onset of disability, the "cause and the "cure for MS remain elusive. This volume of International Review of Neurobiology focuses on MS and related disorders. The volume can be divided into various sections with the main emphasis on MS pathogenesis, clinical features and epidemiology, neuroimaging, and treatment. The ultimate goal of this book is to encourage further research into the pathogenesis of this elusive disease.

In this issue of Neuroimaging Clinics, guest editors Drs. Mahmud Mossa-Basha, Carlos Zamora, and Mauricio Castillo bring their considerable expertise to the topic of Vasculitis. Both conventional and advanced imaging play a central role in the diagnosis of vasculitides, and in this issue, top experts in the field discuss classification, guidelines, diagnosis, pathology, and imaging of every major type of vasculitis. - Contains 14 relevant, practice-oriented topics including classification and guidelines for diagnosis of vasculitis; clinical diagnosis, manifestations and treatment of infectious and post-infectious vasculopathies; usefulness of different imaging methods in the diagnosis of cerebral vasculopathy; imaging of vasculitis associated with systemic disease (RA, lupus, sarcoid); and more. - Provides in-depth clinical reviews on vasculitis, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.