This manual is a comprehensive compilation of "methods that work" for deriving, characterizing, and differentiating hPSCs, written by the researchers who developed and tested the methods and use them every day in their laboratories. The manual is much more than a collection of recipes; it is intended to spark the interest of scientists in areas of stem cell biology that they may not have considered to be important to their work. The second edition of the Human Stem Cell Manual is an extraordinary laboratory guide for both experienced stem cell researchers and those just beginning to use stem cells in their work. - Offers a comprehensive guide for medical and biology researchers who want to use stem cells for basic research, disease modeling, drug development, and cell therapy applications - Provides a cohesive global view of the current state of stem cell research, with chapters written by pioneering stem cell researchers in Asia, Europe, and North America - Includes new chapters devoted to recently developed methods, such as iPSC technology, written by the scientists who made these breakthroughs

This entertaining book presents a collection of 180 famous mathematical puzzles and intriguing elementary problems that great mathematicians have posed, discussed, and/or solved. The selected problems do not require advanced mathematics, making this book accessible to a variety of readers. Mathematical recreations offer a rich playground for both amateur and professional mathematicians. Believing that creative stimuli and aesthetic considerations are closely related, great mathematicians from ancient times to the present have always taken an interest in puzzles and diversions. The goal of this book is to show that famous mathematicians have all communicated brilliant ideas, methodological approaches, and absolute genius in mathematical thoughts by using recreational mathematics as a framework. Concise biographies of many mathematicians mentioned in the text are also included. The majority of the mathematical problems presented in this book originated in number theory, graph theory, optimization, and probability. Others are based on combinatorial and chess problems, while still others are geometrical and arithmetical puzzles. This book is intended to be both entertaining as well as an introduction to various intriguing mathematical topics and ideas. Certainly, many stories and famous puzzles can be very useful to prepare classroom lectures, to inspire and amuse students, and to instill affection for mathematics.

This series balances the need for thorough, comprehensive grammar practice with exercises and illustrations. The series is designed for beginning and intermediate level English language students. Each book contains clear grammar explanations, regular revision units and recycled grammar practice.

The Cambridge History of Classical Literature, Volume 1 offers a comprehensive survey of Greek literature from Homer to end of the period of stable Graeco-Roman civilation in the third century A.D. It embodies the advances made by recent classical scholarship and pays particular attention to texts that have become known in modern times. After its success in hardcover, this volume is now being issued in four paperback parts, providing individual texts on early Greek poetry, Greek drama, philosophy, history and oratory, and on the literature of the Hellenistic period and the Empire. A chapter on books and readers in the Greek world concludes Part 4. Each part has its own appendix of authors and works, a list of works cited, and an index.

There is no more important area of the body for an athlete than the core, the region of our body from our chest to our knees. The core is our engine, our hub of activity. Strength there makes life easier for shoulders and knees. It produces speed and explosiveness. Endurance and grit. The core is so important. So why has it remained such a medical mystery? This book will explain that. Introducing the Core: Demystifying the Body of an Athlete traces the arc of the journey from injury to restoration of power to the return to normal life. Dr. William Meyers is the nation’s foremost authority on core health. Along with over 40 world-renowned expert contributors, Dr. Meyers explains how the core functions through stories from his work in locker rooms, the operating room, and the playing fields of elite athletes, giving readers a thorough understanding of the core’s widespread influence on athleticism and the human anatomy. The book: Dissects the events that led Dr. Meyers and his team of experts to their new appreciation of this anatomy Brings multiple world-renowned arthroscopists into the overall core picture, providing their perspectives on how the core works, with the pubic bone as “the sun” of the body’s universe Offers insight into the many causes of pelvic pain, demonstrating why the term “sports hernia,” should be banished forever Emphasizes the fact that a wide spectrum of professionals treat the core -- from traditional surgeons to alternative therapists Brings it all together and proposes a new future, and perhaps a new medical specialty, that is the core “Strength, power, and endurance all flow from the core. This book, and the work Bill Meyers has done in the field, will bring good core health to the forefront and help everyone—elite athletes and others.” —Michael William Krzyzewski “Even in baseball, injury patterns in the shoulder and elbow are related to core imbalance. This book has been needed for a long time... Bill has helped the idea of core strength become more popular, and this book could be what is needed to get it more attention.” —James Rheuben Andrews, MD “To understand the core, you must put on new eyes.” —Marshawn Lynch

Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.