Molecular mechanisms underlying polycystic kidney disease: From the smallest bricks to the big scenario
Title | Molecular mechanisms underlying polycystic kidney disease: From the smallest bricks to the big scenario PDF eBook |
Author | Annarita Di Mise |
Publisher | Frontiers Media SA |
Pages | 170 |
Release | 2024-05-29 |
Genre | Science |
ISBN | 2832549802 |
Cystogenesis
Title | Cystogenesis PDF eBook |
Author | Jong Hoon Park |
Publisher | Springer |
Pages | 128 |
Release | 2016-10-12 |
Genre | Medical |
ISBN | 9811020418 |
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Molecular Mechanisms of Polycystic Kidney Disease
Title | Molecular Mechanisms of Polycystic Kidney Disease PDF eBook |
Author | |
Publisher | |
Pages | 155 |
Release | 2011 |
Genre | |
ISBN |
Molecular Mechanism of Functions of Polycystic Kidney Disease (PKD) Proteins
Title | Molecular Mechanism of Functions of Polycystic Kidney Disease (PKD) Proteins PDF eBook |
Author | Parul Kashyap |
Publisher | |
Pages | 216 |
Release | 2018 |
Genre | |
ISBN |
Porth
Title | Porth PDF eBook |
Author | Carol Mattson Porth |
Publisher | |
Pages | 0 |
Release | 2009 |
Genre | |
ISBN | 9781608312986 |
The Metabolic Ghetto
Title | The Metabolic Ghetto PDF eBook |
Author | Jonathan C. K. Wells |
Publisher | Cambridge University Press |
Pages | 625 |
Release | 2016-07-21 |
Genre | Business & Economics |
ISBN | 1107009472 |
A multidisciplinary analysis of the role of nutrition in generating hierarchical societies and cultivating a global epidemic of chronic diseases.
Concepts and Principles of Pharmacology
Title | Concepts and Principles of Pharmacology PDF eBook |
Author | James E. Barrett |
Publisher | Springer Nature |
Pages | 466 |
Release | 2019-12-24 |
Genre | Medical |
ISBN | 3030353621 |
Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.