Molecular Aspects of Bioelectricity describes the self-organization in molecular and cellular networks. This book evaluates the chemical representation of ion flux gating in excitable biomembranes and addresses the theoretical implication of liganding reactions in axonal sodium channel gating. It also strongly demonstrates the ligand interactions of crustacean axonal membrane. The opening chapters deal with the biochemical studies of the structure, mechanism, and differentiation of the voltage-sensitive sodium channel; and biochemical cycle of impedance variation in axonal membranes. The succeeding chapters examine the effect of various compounds on the phosphorylation of nerve proteins and the molecular aspects of the actions of cyclic nucleotides at synapses. These topics are followed by discussions of the acetylcholine and choline acetyltransferase, as well as the polymorphism of cholinesterase in vertebrates. The closing chapters are devoted to the physical factors determining gated flux from and into sealed membrane fragments. The book can provide useful information to biologists, students, and researchers.

Recent advances in technology have led to the unprecedented accuracy in measurements of endogenous electric fields around sites of tissue disruption. State-of-the-art molecular approaches demonstrate the role of bioelectricity in the directionality and speed of cell migration, proliferation, apoptosis, differentiation, and orientation. New informat

Bioimpedance and Bioelectricity Basics, 3rd Edition paves an easier and more efficient way for people seeking basic knowledge about this discipline. This book's focus is on systems with galvanic contact with tissue, with specific detail on the geometry of the measuring system. Both authors are internationally recognized experts in the field. The highly effective, easily followed organization of the second edition has been retained, with a new discussion of state-of-the-art advances in data analysis, modelling, endogenic sources, tissue electrical properties, electrodes, instrumentation and measurements. This book provides the basic knowledge of electrochemistry, electronic engineering, physics, physiology, mathematics, and model thinking that is needed to understand this key area in biomedicine and biophysics. - Covers tissue immittance from the ground up in an intuitive manner, supported with figures and examples - New chapters on electrodes and statistical analysis - Discusses in detail dielectric and electrochemical aspects, geometry and instrumentation as well as electrical engineering concepts of network theory, providing a cross-disciplinary resource for engineers, life scientists, and physicists

This open access book describes modern applications of computational human modeling with specific emphasis in the areas of neurology and neuroelectromagnetics, depression and cancer treatments, radio-frequency studies and wireless communications. Special consideration is also given to the use of human modeling to the computational assessment of relevant regulatory and safety requirements. Readers working on applications that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest developments in computational modelling and human phantom development to assess a given technology’s safety and efficacy in a timely manner. Describes construction and application of computational human models including anatomically detailed and subject specific models; Explains new practices in computational human modeling for neuroelectromagnetics, electromagnetic safety, and exposure evaluations; Includes a survey of modern applications for which computational human models are critical; Describes cellular-level interactions between the human body and electromagnetic fields.

Despite the fact that many years have elapsed since the first microcalorimetric measurements of an action potential were made, there is still among the research workers involved in the study of bioelectrogenesis a complete overlooking of the most fundamental principle governing any biological phenomenon at the molecular scale of dimension. This is surprising, the more so that the techniques of molecular biology are applied to characterize the proteins forming the ionic conducting sites in living membranes. For reasons that are still obscure to us the molecular aspects of bioelectrogenesis are completely out of the scope of the dynamic aspects of biochemistry. Even if it is sometimes recognized that an action potential is a free energy-consuming, entropy-producing process, the next question that should reasonably arise is never taken into consideration. There is indeed a complete evasion of the problem of biochemical energy coupling thus reducing the bioelectrogenesis to only physical interactions of membrane proteins with the electric field: the inbuilt postulate is that no molecular transformations, in the chemical sense, could be involved.

Chemical and Molecular Basis of Nerve Activity contains 16 chapters that discuss the significant advances in the study of the molecular events underlying bioelectricity and nerve excitability. After briefly describing the physiology and mechanisms of the nervous system, this book goes on examining the physiologically significant features and nerve activity roles of acetylcholines and acetylcholinesterase. A chapter highlights the mechanism of acetylcholinerase inhibition by nerve gases and insecticides. Other chapters explore the characteristic properties of choline acetylase enzyme; the relationships between chemical forces and electrical activity; and the effect of acetylcholine and analog compounds on the isolation of receptor protein and on synaptic junctions. The remaining chapters deal with the essential role of acetylcholine in the generation of bioelectric current and the differences between axonal conduction and synaptic transmission. The supplementary texts look into the progress in the biochemistry of excitability and present an integral model of nerve excitability. This book will be of great benefit to biologists and neurologists.