A textbook of an intermediate level, this work shows how binary data can be analyzed using a modelling approach, dwelling on practical aspects, incorporating recent work on checking the adequacy of fitted models and showing how computational facilities can be exploited.

Providing reliable information on an intervention effect, meta-analysis is a powerful statistical tool for analyzing and combining results from individual studies. Meta-Analysis of Binary Data Using Profile Likelihood focuses on the analysis and modeling of a meta-analysis with individually pooled data (MAIPD). It presents a unifying approac

Bayesian and Frequentist Regression Methods provides a modern account of both Bayesian and frequentist methods of regression analysis. Many texts cover one or the other of the approaches, but this is the most comprehensive combination of Bayesian and frequentist methods that exists in one place. The two philosophical approaches to regression methodology are featured here as complementary techniques, with theory and data analysis providing supplementary components of the discussion. In particular, methods are illustrated using a variety of data sets. The majority of the data sets are drawn from biostatistics but the techniques are generalizable to a wide range of other disciplines.

Since the original publication of the bestselling Modelling Binary Data, a number of important methodological and computational developments have emerged, accompanied by the steady growth of statistical computing. Mixed models for binary data analysis and procedures that lead to an exact version of logistic regression form valuable additions to the statistician's toolbox, and author Dave Collett has fully updated his popular treatise to incorporate these important advances. Modelling Binary Data, Second Edition now provides an even more comprehensive and practical guide to statistical methods for analyzing binary data. Along with thorough revisions to the original material-now independent of any particular software package- it includes a new chapter introducing mixed models for binary data analysis and another on exact methods for modelling binary data. The author has also added material on modelling ordered categorical data and provides a summary of the leading software packages. All of the data sets used in the book are available for download from the Internet, and the appendices include additional data sets useful as exercises.

Since the original publication of the bestselling Modelling Binary Data, a number of important methodological and computational developments have emerged, accompanied by the steady growth of statistical computing. Mixed models for binary data analysis and procedures that lead to an exact version of logistic regression form valuable additions to the

This book provides a theoretical foundation for the analysis of discrete data such as count and binary data in the longitudinal setup. Unlike the existing books, this book uses a class of auto-correlation structures to model the longitudinal correlations for the repeated discrete data that accommodates all possible Gaussian type auto-correlation models as special cases including the equi-correlation models. This new dynamic modelling approach is utilized to develop theoretically sound inference techniques such as the generalized quasi-likelihood (GQL) technique for consistent and efficient estimation of the underlying regression effects involved in the model, whereas the existing ‘working’ correlations based GEE (generalized estimating equations) approach has serious theoretical limitations both for consistent and efficient estimation, and the existing random effects based correlations approach is not suitable to model the longitudinal correlations. The book has exploited the random effects carefully only to model the correlations of the familial data. Subsequently, this book has modelled the correlations of the longitudinal data collected from the members of a large number of independent families by using the class of auto-correlation structures conditional on the random effects. The book also provides models and inferences for discrete longitudinal data in the adaptive clinical trial set up. The book is mathematically rigorous and provides details for the development of estimation approaches under selected familial and longitudinal models. Further, while the book provides special cares for mathematics behind the correlation models, it also presents the illustrations of the statistical analysis of various real life data. This book will be of interest to the researchers including graduate students in biostatistics and econometrics, among other applied statistics research areas. Brajendra Sutradhar is a University Research Professor at Memorial University in St. John’s, Canada. He is an elected member of the International Statistical Institute and a fellow of the American Statistical Association. He has published about 110 papers in statistics journals in the area of multivariate analysis, time series analysis including forecasting, sampling, survival analysis for correlated failure times, robust inferences in generalized linear mixed models with outliers, and generalized linear longitudinal mixed models with bio-statistical and econometric applications. He has served as an associate editor for six years for Canadian Journal of Statistics and for four years for the Journal of Environmental and Ecological Statistics. He has served for 3 years as a member of the advisory committee on statistical methods in Statistics Canada. Professor Sutradhar was awarded 2007 distinguished service award of Statistics Society of Canada for his many years of services to the society including his special services for society’s annual meetings.

Basic concepts of stationary processes; Sufficient statistics for binary Markov chains; The distribution of the number of axis-crossing; Upcrossings of a high level by a stationary process; Clipping a gaussian process; Estimation in ar(1) after hard limiting; Estimation in ar(p); Runs and estimates of correlations; Spectral analysis after clipping; Extremes in stationary time series; A central limit (ACL); Prediction in binary data.