Modelling and Control of Biotechnological Processes contains the proceedings of the International Federation of Automatic Control's First Symposium on Modeling and Control of Biotechnological Processes held in Noordwijkerhout, The Netherlands, on December 11-13, 1985. The papers explore modeling and control of biotechnological processes such as fermentation and biological wastewater treatment. This book consists of 37 chapters divided into 11 sections and begins with a discussion on the control of fermentation processes; modeling of biotechnical processes; and application of measurement and estimation techniques to biotechnology. The following sections focus on adaptive control theory, applications of adaptive control, and control and modeling of bioreactors. The reader is also introduced to measurement techniques and sensors, with emphasis on pyrolysis mass spectrometry; rapid bioelectrochemical methods; and a self-tuning controller for multiloop controlled fed-batch fermentation. The remaining sections deal with parameter identification and estimation; Kalman filtering techniques; optimization of production processes; modeling of microkinetics; and optimization theory. This monograph will be of interest to researchers and practitioners in the field of biotechnology.

Alongside presenting the fundamentals, this book reviews the state of the art of mathematical modeling and control of bioprocesses, while demonstrating the application in various biological systems important to industry. At the same time, the application of different types of models and control strategies are illustrated, taking into account the recent developments in reactor modeling. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.

Richard Fox Chairman, Scientific Programme Committee Between 25th and 29th September, 1988, 243 people who either apply or research the use of computers in fermentation gathered together at Robinson College, Cambridge, UK. They came from 30 countries. The conference brought together two traditions. Firstly, it continued the series on Computer Applications in Fermentation Technology (ICCAFT) inaugurated by Henri Blanchere in Dijon in 1973 and carried forward in Philadelphia and Manchester. Secondly, it brought the expertise of the many members of the International Federation of Automatic Control (IFAC), who focused their attention on biotechnology at Noordwijkerhout in the Netherlands in December, 1985. I am happy to say that the tradition carries on and a successor meeting will hopefully take place in the USA in 1991. If you find these proceedings useful or stimulating, then we hope to see you there. We set out to make ICCAFT4 a close-knit friendly conference. We housed all who cared to in Robinson College itself and organised no parallel sessions. Because we, the organisers, experience difficulty with the jargon of our colleagues from other disciplines, we asked Bruce Beck to present a breakfast tutorial on modern control and modelling techniques, and we set up informal panel discussions after dinner on two evenings. Neville Fish chaired a forum on the microbiological principles behind models, while Professors Derek Linkens and Ron Leigh led a discussion on expert systems in control.

Modeling and Control of Biotechnical Processes covers the proceedings of the First International Federation of Automatic Control Workshop by the same title, held in Helsinki, Finland on August 17-19, 1982. This book is organized into seven sections encompassing 37 chapters. The opening section deals with the measurement techniques in fermentation processes and the use of automated analyzers to control microbial processes. The next sections consider the concepts of bioreactor modeling and related problems, as well as the modeling and control of biological wastewater treatment processes. Other sections discuss the economic and static optimization, the computer control of production processes, and the application of estimation and identification methods to biotechnological processes. The final sections explore the principles of real-time analysis, use of computer control in specific biotechnical production, process control design, and the modeling of adaptive control. This book is of great value to biotechnologists, biochemists, and control engineers.

Mostindustrialbiotechnologicalprocessesareoperatedempirically.Oneofthe major di?culties of applying advanced control theories is the highly nonlinear nature of the processes. This book examines approaches based on arti?cial intelligencemethods,inparticular,geneticalgorithmsandneuralnetworks,for monitoring, modelling and optimization of fed-batch fermentation processes. The main aim of a process control is to maximize the ?nal product with minimum development and production costs. This book is interdisciplinary in nature, combining topics from biotechn- ogy, arti?cial intelligence, system identi?cation, process monitoring, process modelling and optimal control. Both simulation and experimental validation are performed in this study to demonstrate the suitability and feasibility of proposed methodologies. An online biomass sensor is constructed using a - current neural network for predicting the biomass concentration online with only three measurements (dissolved oxygen, volume and feed rate). Results show that the proposed sensor is comparable or even superior to other sensors proposed in the literature that use more than three measurements. Biote- nological processes are modelled by cascading two recurrent neural networks. It is found that neural models are able to describe the processes with high accuracy. Optimization of the ?nal product is achieved using modi?ed genetic algorithms to determine optimal feed rate pro?les. Experimental results of the corresponding production yields demonstrate that genetic algorithms are powerful tools for optimization of highly nonlinear systems. Moreover, a c- bination of recurrentneural networks and genetic algorithms provides a useful and cost-e?ective methodology for optimizing biotechnological processes.

Biochemical Engineering and Biotechnology, 2nd Edition, outlines the principles of biochemical processes and explains their use in the manufacturing of every day products. The author uses a diirect approach that should be very useful for students in following the concepts and practical applications. This book is unique in having many solved problems, case studies, examples and demonstrations of detailed experiments, with simple design equations and required calculations. - Covers major concepts of biochemical engineering and biotechnology, including applications in bioprocesses, fermentation technologies, enzymatic processes, and membrane separations, amongst others - Accessible to chemical engineering students who need to both learn, and apply, biological knowledge in engineering principals - Includes solved problems, examples, and demonstrations of detailed experiments with simple design equations and all required calculations - Offers many graphs that present actual experimental data, figures, and tables, along with explanations