This is a practical guide for safe and effective use of blood as a drug. It has a practical focus, with a format that blends transfusion science with clinical concerns, and includes contributions from the areas of pathology, internal medicine, surgery, anaesthesiology and paediatrics. This new edition includes 15 new chapters, and the Organization of Blood Services section has been restructured to guide the reader through the intensified regulatory environment and the use of computers a control devices. The text also discusses how blood banks can meet the FDA's tight new guidelines, using audit and error management as the key to process control.