This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

This book discusses the major Natural and Alternative treatments for the Herpes Family viruses that have been documented in the Scientific and Medical Literature. It discusses several nutritional supplements and inexpensive over-the-counter medications that boost the immune system. It also discusses several foods, supplements and herbs that have anti-viral properties. The emphasis is on correlating potential natural and alternative therapies with relevant published research. Some have substantial supporting research and others very little. Get the documented facts, not unfounded claims.

Get problem-oriented and disease-specific guidance in treating STDs-in one quick-access source Featuring the trusted, practical format of the CURRENT series, this authoritative, quick-access guide delivers a top-to-bottom overview of STDs commonly encountered in clinical practice. The book begins with an insightful introduction to the field that emphasizes the patient-doctor relationship, and then explores clinical problems with STDs in terms of diagnostic, management, and treatment considerations. Features A-to-Z, up-to-the-minute coverage of common STDs-filled with crucial point-of-care guidelines A focus on prevention interventions, including counseling, in recognition of the need to change high-risk sexual behaviors Practical diagnostic algorithms that summarize key protocols and facilitate patient management Detailed, easy-to-locate treatment tables that list specific drugs (generic and trade names), doses, and schedules A thought-provoking final chapter that includes a brief discussion of the latest STD research, plus unresolved questions and future concerns Useful appendices that include diagnostic protocols, treatment tables, and websites for further information Authoritative, on-the-spot information you can quickly apply to your practice - without sifting through pages of data An essential clinical companion for internists, family physicians, pediatricians, nurse practitioners, obstetricians-gynecologists, HIV care specialists, and other healthcare professionals who see patients with STDs Turn to any chapter on specific STDs, and you'll find expert perspectives on biology, epidemiology, clinical manifestations, diagnosis, treatment, prevention, and issues related to special populations

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Antiviral chemotherapy has come of age, and, after an initial slow pro gress, the development of new antiviral agents has proceeded at a more rapid pace and the perspectives for their clinical use have increased considerably. Now, 25 years after the first antiviral assay (idoxuridine) was introduced in the clinic, it is fitting to commemorate the beginning of the antivirals' era. In its introductory chapter B.E. Juel-Jensen touches on what may be con sidered as five of the most fundamental requirements of an antiviral drug : efficacy, relative non-toxicity, easy solubility, ready availability and rea sonable cost. Surely, the antiviral drugs that have so far been used in the clinic could still be improved upon as one or more of these five essential demands are concerned. How is all began is narrated by W.H. Prusoff. The first antiviral drugs to be used in humans were methisazone and idoxuridine, the former, which is now of archival interest, in the prevention of smallpox, the latter, which was approved for clinical use in the United States in 1962, for the topical treatment of herpetic keratitis. In terms of potency, also because of solubility reasons, idoxuridine has been superseded by trifluridine in the topical treatment of herpes simplex epithelial keratitis. H.E. Kaufman did not find trifluridine or acyclovir ef fective in the treatment of deep stromal keratitis or iritis and he reckons that other antiviral drugs (i.e. bromovinyldeoxyuridine) would not be effec tive either.

This work brings together knowledge about the pain of herpes zoster and postherpetic neuralgia. The volume aims to expand knowledge not only of this specialized syndrome, but of every kind of chronic pain. It deals with all the basic scientific information on the acute and chronic stages of herpes zoster, as well as knowledge of all the possible treatments for this terrible affliction. A variety of treatment modalities are described, and more people are now obtaining relief than was thought possible a decade ago. research, leading to a more thorough understanding of the problems and to pain relief for those who continue to suffer.

Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth study information on the structure and functions of polymerases and their roles in the lifecycle of viruses, and as drug targets. Viral polymerases constitute a vital component in the lifecycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favorable targets for the design and development of antiviral drugs. - Provides comprehensive, state-of-the-art coverage on virus infections, the virus lifecycle, and mechanisms of polymerase inhibition - Analyzes the structure-activity relationships of inhibitors of each viral polymerase - Presents a consistent and comprehensive coverage of all aspects of viral polymerases, including structure, function and their role as antiviral drug targets