Regulation of Tissue Oxygenation, Second Edition

Regulation of Tissue Oxygenation, Second Edition
Title Regulation of Tissue Oxygenation, Second Edition PDF eBook
Author Roland N. Pittman
Publisher Biota Publishing
Pages 117
Release 2016-08-18
Genre Medical
ISBN 1615047212

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This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

Mechanisms of Systemic Regulation

Mechanisms of Systemic Regulation
Title Mechanisms of Systemic Regulation PDF eBook
Author Norbert Heisler
Publisher Springer Science & Business Media
Pages 251
Release 2012-12-06
Genre Science
ISBN 3642796664

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Mechanisms of Systemic Regulation: Acid—Base Regulation, Ion-Transfer and Metabolism

Mechanisms of Systemic Regulation: Acid—Base Regulation, Ion-Transfer and Metabolism
Title Mechanisms of Systemic Regulation: Acid—Base Regulation, Ion-Transfer and Metabolism PDF eBook
Author Norbert Heisler
Publisher Springer Science & Business Media
Pages 276
Release 2012-12-06
Genre Science
ISBN 3642523633

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The Cerebral Circulation

The Cerebral Circulation
Title The Cerebral Circulation PDF eBook
Author Marilyn J. Cipolla
Publisher Biota Publishing
Pages 82
Release 2016-07-28
Genre Medical
ISBN 1615047239

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This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Quantifying Systemic Risk

Quantifying Systemic Risk
Title Quantifying Systemic Risk PDF eBook
Author Joseph G. Haubrich
Publisher University of Chicago Press
Pages 286
Release 2013-01-24
Genre Business & Economics
ISBN 0226319288

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In the aftermath of the recent financial crisis, the federal government has pursued significant regulatory reforms, including proposals to measure and monitor systemic risk. However, there is much debate about how this might be accomplished quantitatively and objectively—or whether this is even possible. A key issue is determining the appropriate trade-offs between risk and reward from a policy and social welfare perspective given the potential negative impact of crises. One of the first books to address the challenges of measuring statistical risk from a system-wide persepective, Quantifying Systemic Risk looks at the means of measuring systemic risk and explores alternative approaches. Among the topics discussed are the challenges of tying regulations to specific quantitative measures, the effects of learning and adaptation on the evolution of the market, and the distinction between the shocks that start a crisis and the mechanisms that enable it to grow.

Regulation of Coronary Blood Flow

Regulation of Coronary Blood Flow
Title Regulation of Coronary Blood Flow PDF eBook
Author Michitoshi Inoue
Publisher Springer Science & Business Media
Pages 330
Release 2013-11-09
Genre Medical
ISBN 4431683674

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Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

Systemic Risk, Crises, and Macroprudential Regulation

Systemic Risk, Crises, and Macroprudential Regulation
Title Systemic Risk, Crises, and Macroprudential Regulation PDF eBook
Author Xavier Freixas
Publisher MIT Press
Pages 487
Release 2015-06-19
Genre Business & Economics
ISBN 0262028697

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A framework for macroprudential regulation that defines systemic risk and macroprudential policy, describes macroprudential tools, and surveys the effectiveness of existing macroprudential regulation. The recent financial crisis has shattered all standard approaches to banking regulation. Regulators now recognize that banking regulation cannot be simply based on individual financial institutions' risks. Instead, systemic risk and macroprudential regulation have come to the forefront of the new regulatory paradigm. Yet our knowledge of these two core aspects of regulation is still limited and fragmented. This book offers a framework for understanding the reasons for the regulatory shift from a microprudential to a macroprudential approach to financial regulation. It defines systemic risk and macroprudential policy, cutting through the generalized confusion as to their meaning; contrasts macroprudential to microprudential approaches; discusses the interaction of macroprudential policy with macroeconomic policy (monetary policy in particular); and describes macroprudential tools and experiences with macroprudential regulation around the world. The book also considers the remaining challenges for establishing effective macroprudential policy and broader issues in regulatory reform. These include the optimal size and structure of the financial system, the multiplicity of regulatory bodies in the United States, the supervision of cross-border financial institutions, and the need for international cooperation on macroprudential policies.