This thesis presents the first measurement of charmed D0 meson production relative to the reaction plane in Pb–Pb collisions at the center-of-mass energy per nucleon-nucleon collision of √sNN = 2.76 TeV. It also showcases the measurement of the D0 production in p–Pb collisions at √sNN = 5.02 TeV with the ALICE detector at the CERN Large Hadron Collider. The measurement of the D0 azimuthal anisotropy with respect to the reaction plane indicates that low- momentum charm quarks participate in the collective expansion of the high-density, strongly interacting medium formed in ultra-relativistic heavy-ion collisions, despite their large mass. This behavior can be explained by charm hadronization via recombination with light quarks from the medium and collisional energy loss. The measurement of the D0 production in p–Pb collisions is crucial to separate the effect induced by cold nuclear matter from the final- state effects induced by the hot medium formed in Pb–Pb collisions. The D0 production in p–Pb collisions is consistent with the binary collision scaling of the production in pp collisions, demonstrating that the modification of the momentum distribution observed in Pb–Pb collisions with respect to pp is predominantly induced by final-state effects such as the charm energy loss.

Charged-particle spectra at midrapidity are measured in Pb-Pb collisions at the centre-of-mass energy per nucleon-nucleon pair √sNN = 5.02 TeV and presented in centrality classes ranging from most central (0-5%) to most peripheral (95-100%) collisions. Possible medium effects are quantified using the nuclear modification factor (RAA) by comparing the measured spectra with those from proton-proton collisions, scaled by the number of independent nucleon-nucleon collisions obtained from a Glauber model. At large transverse momenta (8

Abstract: Heavy-flavour hadron production provides information about the transport properties and microscopic structure of the quark-gluon plasma created in ultra-relativistic heavy-ion collisions. A measurement of the muons from semileptonic decays of charm and bottom hadrons produced in Pb+Pb and pp collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV with the ATLAS detector at the Large Hadron Collider is presented. The Pb+Pb data were collected in 2015 and 2018 with sampled integrated luminosities of and , respectively, and pp data with a sampled integrated luminosity of were collected in 2017. Muons from heavy-flavour semileptonic decays are separated from the light-flavour hadronic background using the momentum imbalance between the inner detector and muon spectrometer measurements, and muons originating from charm and bottom decays are further separated via the muon track's transverse impact parameter. Differential yields in Pb+Pb collisions and differential cross sections in pp collisions for such muons are measured as a function of muon transverse momentum from 4 GeV to 30 GeV in the absolute pseudorapidity interval . Nuclear modification factors for charm and bottom muons are presented as a function of muon transverse momentum in intervals of Pb+Pb collision centrality. The bottom muon results are the most precise measurement of b quark nuclear modification at low transverse momentum where reconstruction of B hadrons is challenging. The measured nuclear modification factors quantify a significant suppression of the yields of muons from decays of charm and bottom hadrons, with stronger effects for muons from charm hadron decays

The pT-differential production cross sections of the prompt charmed mesons D0, D+, D*+, and D+s and their charge conjugate in the rapidity interval –0.96 ysubcms/sub 0.04 were measured in p–Pb collisions at a center-of-mass energy √ssubNN/sub = 5.02 TeV with the ALICE detector at the LHC. The nuclear modification factor RsubpPb/sub, quantifying the D-meson yield in p–Pb collisions relative to the yield in pp collisions scaled by the number of binary nucleon-nucleon collisions, is compatible within the 15%–20% uncertainties with unity in the transverse momentum interval 1 psubT

Here, the production of prompt Ds+ mesons was measured for the first time in collisions of heavy nuclei with the ALICE detector at the LHC. The analysis was performed on a data sample of Pb-Pb collisions at a centre-of-mass energy per nucleon pair, √sNN, of 2.76 TeV in two different centrality classes, namely 0-10% and 20-50%. Ds+ mesons and their antiparticles were reconstructed at mid-rapidity from their hadronic decay channel Ds+ → [Phi][pi]+, with [Phi] → K-K+, in the transverse momentum intervals 4