Measurement and Analysis of Kinetic Isotope Effects
Title | Measurement and Analysis of Kinetic Isotope Effects PDF eBook |
Author | |
Publisher | Academic Press |
Pages | 634 |
Release | 2017-09-12 |
Genre | Medical |
ISBN | 0128122749 |
Experimental Analysis of Enzyme Mechanism Using Isotope Effects, Volume 596, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this comprehensive update include Measurement of enzyme binding isotope effects, Chemical ligation and isotope labeling to locate dynamic effects, Measurement of heavy enzyme isotope effects, Extracting kinetic isotope effects from a global analysis of reaction progress curves, KIE of metabolic flux and enzymes, Solvent and Primary KIE on Flavin Enzymes, and The Rapid Determination of Primary Deuterium Isotope Effects on Enzyme-Catalyzed Proton Transfer at Carbon in 50/50 HOH/DOD. Readers who are interested in applying or understanding this research will find useful methods currently used for measuring isotope effects on solution and enzyme reactions. Written by pioneers of modern isotope effect research Is the only collection of modern kinetic isotope effect methods currently available
Isotope Effects In Chemistry and Biology
Title | Isotope Effects In Chemistry and Biology PDF eBook |
Author | Amnon Kohen |
Publisher | CRC Press |
Pages | 1092 |
Release | 2005-11-01 |
Genre | Medical |
ISBN | 1420028022 |
The field of isotope effects has expanded exponentially in the last decade, and researchers are finding isotopes increasingly useful in their studies. Bringing literature on the subject up to date, Isotope Effects in Chemistry and Biology covers current principles, methods, and a broad range of applications of isotope effects in the physical, biolo
Isotope Effects on Reaction Rates
Title | Isotope Effects on Reaction Rates PDF eBook |
Author | Lars C. S. Melander |
Publisher | |
Pages | 200 |
Release | 1960 |
Genre | Chemical kinetics |
ISBN |
Enzyme Mechanism from Isotope Effects
Title | Enzyme Mechanism from Isotope Effects PDF eBook |
Author | Paul F. Cook |
Publisher | CRC Press |
Pages | 656 |
Release | 1991-09-20 |
Genre | Medical |
ISBN | 9780849353123 |
Isotope effects have become one of the most powerful tools available to the enzymologist for probing enzymic mechanisms. Enzyme Mechanism from Isotope Effects presents the basic theory underlying isotope effects, including the latest findings on proton tunneling and coupled atomic notions. Specific theoretical applications are emphasized in regard to the types of information that can be obtained using isotope effects. The book also examines recent theoretical treatments of the product dependence of deuterium isotope effects, multiple isotope effects and isotope effects on intermediate partitioning. Other topics include a complete discussion of methods for measuring isotope effects, including a detailed description of the use of the isotope ratio mass spectrometer to obtain isotope effects, and a review of the literature regarding mechanistic information obtained from isotope effects for individual classes of enzyme-catalyzed reactions. Enzyme Mechanism from Isotope Effects is an excellent reference source for investigators using isotope effects in their research. The book is also valuable for reference libraries and instructors teaching courses in enzyme mechanism.
Heavy Atom Isotope Effects
Title | Heavy Atom Isotope Effects PDF eBook |
Author | E. Buncel |
Publisher | |
Pages | 368 |
Release | 1992 |
Genre | Chemical kinetics |
ISBN |
The Elucidation of Mechanism and Transition State Structure for Enzyme and Non-enzyme Catalyzed Reactions with the Aid of Novel Methods for the Measurement of Oxygen-18 Isotope Effects
Title | The Elucidation of Mechanism and Transition State Structure for Enzyme and Non-enzyme Catalyzed Reactions with the Aid of Novel Methods for the Measurement of Oxygen-18 Isotope Effects PDF eBook |
Author | Steven Rosenberg |
Publisher | |
Pages | 692 |
Release | 1978 |
Genre | |
ISBN |
Understanding Organometallic Reaction Mechanisms and Catalysis
Title | Understanding Organometallic Reaction Mechanisms and Catalysis PDF eBook |
Author | Valentin P. Ananikov |
Publisher | John Wiley & Sons |
Pages | 483 |
Release | 2014-08-29 |
Genre | Science |
ISBN | 3527678220 |
Exploring and highlighting the new horizons in the studies of reaction mechanisms that open joint application of experimental studies and theoretical calculations is the goal of this book. The latest insights and developments in the mechanistic studies of organometallic reactions and catalytic processes are presented and reviewed. The book adopts a unique approach, exemplifying how to use experiments, spectroscopy measurements, and computational methods to reveal reaction pathways and molecular structures of catalysts, rather than concentrating solely on one discipline. The result is a deeper understanding of the underlying reaction mechanism and correlation between molecular structure and reactivity. The contributions represent a wealth of first-hand information from renowned experts working in these disciplines, covering such topics as activation of small molecules, C-C and C-Heteroatom bonds formation, cross-coupling reactions, carbon dioxide converison, homogeneous and heterogeneous transition metal catalysis and metal-graphene systems. With the knowledge gained, the reader will be able to improve existing reaction protocols and rationally design more efficient catalysts or selective reactions. An indispensable source of information for synthetic, analytical, and theoretical chemists in academia and industry.