“Oliver Sacks meets Stephen King”* in this propulsive, haunting journey into the life of the most studied human research subject of all time, the amnesic known as Patient H.M. For readers of The Immortal Life of Henrietta Lacks comes a story that has much to teach us about our relentless pursuit of knowledge. Winner of the PEN/E.O. Wilson Literary Science Writing Award • Los Angeles Times Book Prize Winner NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The Washington Post • New York Post • NPR • The Economist • New York • Wired • Kirkus Reviews • BookPage In 1953, a twenty-seven-year-old factory worker named Henry Molaison—who suffered from severe epilepsy—received a radical new version of the then-common lobotomy, targeting the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry was left profoundly amnesic, unable to create long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today. Patient H.M. is, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves. Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons, as they called themselves, conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide. “An exciting, artful blend of family and medical history.”—The New York Times *Kirkus Reviews (starred review)

In 1953, 27-year-old Henry Gustave Molaison underwent an experimental "psychosurgical" procedure -- a targeted lobotomy -- in an effort to alleviate his debilitating epilepsy. The outcome was unexpected -- when Henry awoke, he could no longer form new memories, and for the rest of his life would be trapped in the moment. But Henry's tragedy would prove a gift to humanity. As renowned neuroscientist Suzanne Corkin explains in Permanent Present Tense, she and her colleagues brought to light the sharp contrast between Henry's crippling memory impairment and his preserved intellect. This new insight that the capacity for remembering is housed in a specific brain area revolutionized the science of memory. The case of Henry -- known only by his initials H. M. until his death in 2008 -- stands as one of the most consequential and widely referenced in the spiraling field of neuroscience. Corkin and her collaborators worked closely with Henry for nearly fifty years, and in Permanent Present Tense she tells the incredible story of the life and legacy of this intelligent, quiet, and remarkably good-humored man. Henry never remembered Corkin from one meeting to the next and had only a dim conception of the importance of the work they were doing together, yet he was consistently happy to see her and always willing to participate in her research. His case afforded untold advances in the study of memory, including the discovery that even profound amnesia spares some kinds of learning, and that different memory processes are localized to separate circuits in the human brain. Henry taught us that learning can occur without conscious awareness, that short-term and long-term memory are distinct capacities, and that the effects of aging-related disease are detectable in an already damaged brain. Undergirded by rich details about the functions of the human brain, Permanent Present Tense pulls back the curtain on the man whose misfortune propelled a half-century of exciting research. With great clarity, sensitivity, and grace, Corkin brings readers to the cutting edge of neuroscience in this deeply felt elegy for her patient and friend.

Clive Wearing has one of the most extreme cases of amnesia ever known. In 1985, a virus completely destroyed a part of his brain essential for memory, leaving him trapped in a limbo of the constant present. Every conscious moment is for him as if he has just come round from a long coma, an endlessly repeating loop of awakening. A brilliant conductor and BBC music producer, Clive was at the height of his success when the illness struck. As damaged as Clive was, the musical part of his brain seemed unaffected, as was his passionate love for Deborah, his wife. For seven years he was kept in the London hospital where the ambulance first dropped him off, because there was nowhere else for him to go. Deborah desperately searched for treatments and campaigned for better care. After Clive was finally established in a new special hospital, she fled to America to start her life over again. But she found she could never love another the way she loved Clive. Then Clive's memory unaccountably began to improve, ten years after the illness first struck. She returned to England. Today, although Clive still lives in care, and still has the worst case of amnesia in the world, he continues to improve. They renewed their marriage vows in 2002. This is the story of a life lived outside time, a story that questions and redefines the essence of what it means to be human. It is also the story of a marriage, of a bond that runs deeper than conscious thought.

A welcome re-issue of an English translation of Alexander Luria's famous case-history of hypermnestic man. The study remains the classic paradigm of what Luria called 'romantic science,' a genre characterized by individual portraiture based on an assessment of operative psychological processes. The opening section analyses in some detail the subject's extraordinary capacity for recall and demonstrates the association between the persistence of iconic memory and a highly developed synaesthesia. The remainder of the book deals with the subject's construction of the world, his mental strengths and weaknesses, his control of behaviour and his personality. The result is a contribution to literature as well as to science. (Psychological Medicine ).

Finalist for the International Booker Prize and the National Book Award A haunting Orwellian novel about the terrors of state surveillance, from the acclaimed author of The Housekeeper and the Professor. On an unnamed island, objects are disappearing: first hats, then ribbons, birds, roses. . . . Most of the inhabitants are oblivious to these changes, while those few able to recall the lost objects live in fear of the draconian Memory Police, who are committed to ensuring that what has disappeared remains forgotten. When a young writer discovers that her editor is in danger, she concocts a plan to hide him beneath her f loorboards, and together they cling to her writing as the last way of preserving the past. Powerful and provocative, The Memory Police is a stunning novel about the trauma of loss. ONE OF THE BEST BOOKS OF THE YEAR THE NEW YORK TIMES * THE WASHINGTON POST * TIME * CHICAGO TRIBUNE * THE GUARDIAN * ESQUIRE * THE DALLAS MORNING NEWS * FINANCIAL TIMES * LIBRARY JOURNAL * THE A.V. CLUB * KIRKUS REVIEWS * LITERARY HUB American Book Award winner

In the aftermath of a shattering illness, Lonni Sue Johnson lives in a "perpetual now," where she has almost no memories of the past and a nearly complete inability to form new ones. The Perpetual Now is the moving story of this exceptional woman, and the groundbreaking revelations about memory, learning, and consciousness her unique case has uncovered. Lonni Sue Johnson was a renowned artist who regularly produced covers for The New Yorker, a gifted musician, a skilled amateur pilot, and a joyful presence to all who knew her. But in late 2007, she contracted encephalitis. The disease burned through her hippocampus like wildfire, leaving her severely amnesic, living in a present that rarely progresses beyond ten to fifteen minutes. Remarkably, she still retains much of the intellect and artistic skills from her previous life, but it's not at all clear how closely her consciousness resembles yours or mine. As such, Lonni Sue's story has become part of a much larger scientific narrative—one that is currently challenging traditional wisdom about how human memory and awareness are stored in the brain. In this probing, compassionate, and illuminating book, award-winning science journalist Michael D. Lemonick uses the unique drama of Lonni Sue Johnson's day-to-day life to give us a nuanced and intimate understanding of the science that lies at the very heart of human nature.