Malaria and Rome is the first comprehensive study of malaria in ancient Italy since the research of the distinguished Italian malariologist Angelo Celli in the early twentieth century. It demonstrates the importance of disease patterns and history in understanding the demography of ancient populations. Robert Sallares argues that malaria became increasingly prevalent in Roman times in central Italy as a result of ecological change and alterations to the physical landscapesuch as deforestation. Making full use of contemporary sources and comparative material from other periods, he shows that malaria had a significant effect on mortality rates in certain regions of Roman Italy.Robert Sallares incorporates all the important advances made in many relevant fields since Celli's time. These include recent geomorphological research on the evolution of the coastal environments of Italy that were notorious for malaria in the past, biomolecular research on the evolution of malaria, ancient DNA as a new source of evidence for malaria in antiquity, the differentiation of mosquito species that permits understanding of the phenomenon of anophelism without malaria (where theclimate is optimal for malaria and Anopheles mosquitoes are present, but there is no malaria), and recent medical research on the interactions between malaria and other diseases.The argument develops with a careful interplay between the modern microbiology of the disease and the Greek and Latin literary texts. Both contemporary sources and comparative material from other periods are used to interpret the ancient sources. In addition to the medical and demographic effects on the Roman population, Malaria and Rome considers the social and economic effects of malaria, for example on settlement patterns and on agricultural systems. Robert Sallares also examinesthe varied human responses to and interpretations of malaria in antiquity, ranging from the attempts at rational understanding made by the Hippocratic authors and Galen to the demons described in the magical papyri.

Malaria and Rome is the first comprehensive study of malaria in ancient Italy since the research of the distinguished Italian malariologist Angelo Celli in the early twentieth century. It demonstrates the importance of disease patterns and history in understanding the demography of ancient populations. Robert Sallares argues that malaria became increasingly prevalent in Roman times in central Italy as a result of ecological change and alterations to the physical landscape such as deforestation. Making full use of contemporary sources and comparative material from other periods, he shows that malaria had a significant effect on mortality rates in certain regions of Roman Italy. Robert Sallares incorporates all the important advances made in many relevant fields since Celli's time. These include recent geomorphological research on the evolution of the coastal environments of Italy that were notorious for malaria in the past, biomolecular research on the evolution of malaria, ancient DNA as a new source of evidence for malaria in antiquity, the differentiation of mosquito species that permits understanding of the phenomenon of anophelism without malaria (where the climate is optimal for malaria and Anopheles mosquitoes are present, but there is no malaria), and recent medical research on the interactions between malaria and other diseases. The argument develops with a careful interplay between the modern microbiology of the disease and the Greek and Latin literary texts. Both contemporary sources and comparative material from other periods are used to interpret the ancient sources. In addition to the medical and demographic effects on the Roman population, Malaria and Rome considers the social and economic effects of malaria, for example on settlement patterns and on agricultural systems. Robert Sallares also examines the varied human responses to and interpretations of malaria in antiquity, ranging from the attempts at rational understanding made by the Hippocratic authors and Galen to the demons described in the magical papyri.

During the last 1500 years, Rome was the inspiration of artists, the coronation stage of German emperors, the distant desire of pilgrims, and the seat of the Roman popes. Yet Rome also lies within the northern range of P. falciparum malaria, the deadliest strain of the disease, against which northern Europeans had no intrinsic or acquired defenses. As a result, Rome lured a countless number of unacclimated transalpine Europeans to their deaths in the period from 500 to 1850 AD. This book examines how Rome's allure to European visitors and its resident malaria species impacted the historical development of Europe. It covers the environmental and biological factors at play and focuses on two of the periods when malaria potentially had the greatest impact on the continent: the heyday of the medieval German Empire and its conflicts with the papacy (c. 800-1300) and the Protestant Reformation (c.1500). Through explorations into the history of religion, empire, disease, and culture, this book tells the story of how the veritable capital of the world became the graveyard of nations.

At the outset of the twentieth century, malaria was Italy’s major public health problem. It was the cause of low productivity, poverty, and economic backwardness, while it also stunted literacy, limited political participation, and undermined the army. In this book Frank Snowden recounts how Italy became the world center for the development of malariology as a medical discipline and launched the first national campaign to eradicate the disease. Snowden traces the early advances, the setbacks of world wars and Fascist dictatorship, and the final victory against malaria after World War II. He shows how the medical and teaching professions helped educate people in their own self-defense and in the process expanded trade unionism, women’s consciousness, and civil liberties. He also discusses the antimalarial effort under Mussolini’s regime and reveals the shocking details of the German army’s intentional release of malaria among Italian civilians—the first and only known example of bioterror in twentieth-century Europe. Comprehensive and enlightening, this history offers important lessons for today’s global malaria emergency.

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.

**The instant New York Times bestseller.** *An international bestseller.* Finalist for the Lane Anderson Award Finalist for the RBC Taylor Award “Hugely impressive, a major work.”—NPR A pioneering and groundbreaking work of narrative nonfiction that offers a dramatic new perspective on the history of humankind, showing how through millennia, the mosquito has been the single most powerful force in determining humanity’s fate Why was gin and tonic the cocktail of choice for British colonists in India and Africa? What does Starbucks have to thank for its global domination? What has protected the lives of popes for millennia? Why did Scotland surrender its sovereignty to England? What was George Washington's secret weapon during the American Revolution? The answer to all these questions, and many more, is the mosquito. Across our planet since the dawn of humankind, this nefarious pest, roughly the size and weight of a grape seed, has been at the frontlines of history as the grim reaper, the harvester of human populations, and the ultimate agent of historical change. As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power. The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village. Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable. Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito’s reign through human history and her indelible impact on our modern world order.

A fascinating and shocking historical exposé, The Malaria Project is the story of America's secret mission to combat malaria during World War II—a campaign modeled after a German project which tested experimental drugs on men gone mad from syphilis. American war planners, foreseeing the tactical need for a malaria drug, recreated the German model, then grew it tenfold. Quickly becoming the biggest and most important medical initiative of the war, the project tasked dozens of the country’s top research scientists and university labs to find a treatment to remedy half a million U.S. troops incapacitated by malaria. Spearheading the new U.S. effort was Dr. Lowell T. Coggeshall, the son of a poor Indiana farmer whose persistent drive and curiosity led him to become one of the most innovative thinkers in solving the malaria problem. He recruited private corporations, such as today's Squibb and Eli Lilly, and the nation’s best chemists out of Harvard and Johns Hopkins to make novel compounds that skilled technicians tested on birds. Giants in the field of clinical research, including the future NIH director James Shannon, then tested the drugs on mental health patients and convicted criminals—including infamous murderer Nathan Leopold. By 1943, a dozen strains of malaria brought home in the veins of sick soldiers were injected into these human guinea pigs for drug studies. After hundreds of trials and many deaths, they found their “magic bullet,” but not in a U.S. laboratory. America 's best weapon against malaria, still used today, was captured in battle from the Nazis. Called chloroquine, it went on to save more lives than any other drug in history. Karen M. Masterson, a journalist turned malaria researcher, uncovers the complete story behind this dark tale of science, medicine and war. Illuminating, riveting and surprising, The Malaria Project captures the ethical perils of seeking treatments for disease while ignoring the human condition.