Alle relevanten Informationen zu Eisenoxiden, von der Struktur und Transformation über Charakterisierungsverfahren bis hin zu den neuesten AnwendungEN. Ein Muss für alle, die in dem Fachgebiet arbeiten.

Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, ­biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer ­therapeutics—featuring discussion of current problems, ­proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.

The manipulation and control of cells and sub-cellular structures through magnetic nanoparticle-based actuation is a relatively new technique that has led to novel and exciting biomedical applications. Nanomagnetic actuation is being used in laboratory studies of stem cells to determine how these mechanical cues can be used to control stem cell differentiation for regenerative medicine applications. This book explores this rapidly expanding field. It will interest industry bioscientists and biomedical engineers as well as academics in cellular biomechanics, cell and tissue engineering, and regenerative medicine. Key Features Focuses on the fundamentals and applications of magnetic actuation Includes contributions by world-class researchers from several countries and is edited by a well-known researcher in this field Offers multidisciplinary coverage and applications Supplies extensive references at the end of each chapter

What Is Magnetic Nanoparticles Magnetic nanoparticles are a class of nanoparticle that can be manipulated using magnetic fields. Such particles commonly consist of two components, a magnetic material, often iron, nickel and cobalt, and a chemical component that has functionality. While nanoparticles are smaller than 1 micrometer in diameter, the larger microbeads are 0.5–500 micrometer in diameter. Magnetic nanoparticle clusters that are composed of a number of individual magnetic nanoparticles are known as magnetic nanobeads with a diameter of 50–200 nanometers. Magnetic nanoparticle clusters are a basis for their further magnetic assembly into magnetic nanochains. The magnetic nanoparticles have been the focus of much research recently because they possess attractive properties which could see potential use in catalysis including nanomaterial-based catalysts, biomedicine and tissue specific targeting, magnetically tunable colloidal photonic crystals, microfluidics, magnetic resonance imaging, magnetic particle imaging, data storage, environmental remediation, nanofluids, optical filters, defect sensor, magnetic cooling and cation sensors. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Magnetic nanoparticles Chapter 2: Nanoparticle Chapter 3: Coprecipitation Chapter 4: Thermal decomposition Chapter 5: Microemulsion Chapter 6: Iron oxide nanoparticle Chapter 7: Magnetic nanoparticles (II) Answering the public top questions about magnetic nanoparticles. (III) Real world examples for the usage of magnetic nanoparticles in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of magnetic nanoparticles' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of magnetic nanoparticles.

Fe3O4-magetite nanoparticles have received wide interest as prominent agents for various biomedical applications, ranging from target-specific cancer treatment, gene therapy, and Magnetic Particle Imaging (MPI). However, Fe3O4-magnetite nanoparticles, synthesized by chemical methods beyond a certain size, present challenges in controlling size distribution and shape. Similarly, Fe3O4-magnetite nanoparticles fabricated by conventional top-down lithographic methods present difficulty of controlling defects and lead to agglomeration due to large size. In order to overcome the difficulties associated with the conventional chemical and top-down lithographic methods, it is critical to develop a fabrication method which produces homogeneous nanoparticles in large quantities with the control of size, defects, and structure. Furthermore, the concept of cell death induced by mechanical perturbation has received wide attention as a way to maximize the cancer cell death with minimal side effects. Previous study has proposed the use of permalloy disk-shaped vortex state microparticles, in order to create cancer cell death by mechanical force. However, insufficient biocompatibility, inadequate mechanical force created by vortex switching, and inability to control the particle size have been critical issues to be further researched and proceeded for in vivo application. Hence, we studied physical and magnetic properties of Fe3O4 as a material in thin film form and proceeded to develop Fe3O4 based synthetic antiferromagnetic (SAF) thin films. Then, we combined these favorable physical/magnetic properties with nanoimprint lithography to fabricate homogeneously patterned synthetic antiferromagnetic (SAF) nanoparticles (wafer area >1 x 1 cm2) with the control of size, shape and structure. Then we demonstrated the release of these particles in an aqueous environment. The fabrication process combines a tetrafluoroethylene (ETFE) "working stamp", a bi-layer resist lift-off, defect-free nanoimprint and sputtering in order to fabricate synthetic antiferromagnetic (SAF) nanoparticles. SAF nanoparticles are composed of alternating magnetic/non-magnetic multilayers to prevent any agglomeration in spite of the ferromagnetic nature of the particles. This heterostructure gives rise to nearly zero magnetic remanence and coercivity values and also prevents possible oxidation of Fe3O4. The superparamagnet-like behavior (nearly zero remanence and coercivity) of SAF nanoparticles suggests that the SAF nanoparticles with favorable geometry fabricated by top-down methods have potential for biomedical application. In order to prove the suitability of SAF nanoparticles for biomedical application, we initially controlled the movement of these SAF nanoparticles with A.C magnetic field, and mechanically rotated them in solution. After we have studied field frequency dependence on mechanical rotation, these SAF nanoparticles were implemented in in vitro environment to test the biocompatibility of these SAF nanoparticlesn, and also to confirm the effectiveness of mechanical force created by A.C magnetic field in order to kill cancer cells. This proof of concept successfully eradicated cancer cells with these SAF nanoparticles. We have demonstrated the effective cancer death after 16 minutes of exposure to mechanically rotating SAF nanoparticles under frequency of 1 Hz (>92% cell death). Furthermore, under the same frequency and exposure time, we have shown that up to 1:4 (nanoparticles:cell) concentration, the mechanical perturbation is effective to kill cancer cells (>80% cell death). However, we suggest to further study the biological mechanism of cancer cell death by mechanical perturbation to truly understand this phenomenon.

Cell mechanics is the field of study that looks at how cells detect, modify, and respond to the physical properties of the cell environment. Cells communicate with each other through chemical and physical signals which are involved in a range of process from embryogenesis and wound healing to pathological conditions such as cancerous invasion. Similar principles are also likely to be critical for success in regenerative medicine. Cell mechanics is thus central to understanding these principles. As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and mathematics, this book aims not only to provide a collection of research methods, but also to develop a common language among scientists who share the interest in cell mechanics but enter the field with diverse backgrounds. To this end all of the contributing authors have sought to explain in plain language the nature of the biological problems, the rationale for the approaches, in addition to the methods themselves. In addition, to balance practical utility against conceptual advances, Cell Mechanics has intentionally included both chapters that provide detailed recipes and those that emphasize basic principles. - Presents a distinctive emphasis on matrix mechanics and their interplay with cell functions - Includes highly significant topics relevant to basic and translational research, as well as tissue engineering - Emphasizes mechanical input and output of cells

This volume provides a comprehensive overview of recent developments in magnetic particle imaging (MPI), a novel imaging modality. Using various static and oscillating magnetic fields, and tracer materials made from iron oxide nanoparticles, MPI can perform background-free measurements of the particles’ local concentration. The method exploits the nonlinear remagnetization behavior of the particles and has the potential to surpass current methods for the detection of iron oxide in terms of sensitivity and spatiotemporal resolution. Starting from an introduction to the technology, the topics addressed include setting up an imaging device, assessment of image quality, development of new MPI tracer materials, and the first preclinical results. This is the first book to be published on magnetic particle imaging, and it will be an invaluable source of information for everyone with an interest in this exciting new modality.