This book bridges the gap between data scientists and clinicians by introducing all relevant aspects of machine learning in an accessible way, and will certainly foster new and serendipitous applications of machine learning in the clinical neurosciences. Building from the ground up by communicating the foundational knowledge and intuitions first before progressing to more advanced and specific topics, the book is well-suited even for clinicians without prior machine learning experience. Authored by a wide array of experienced global machine learning groups, the book is aimed at clinicians who are interested in mastering the basics of machine learning and who wish to get started with their own machine learning research. The volume is structured in two major parts: The first uniquely introduces all major concepts in clinical machine learning from the ground up, and includes step-by-step instructions on how to correctly develop and validate clinical prediction models. It also includes methodological and conceptual foundations of other applications of machine learning in clinical neuroscience, such as applications of machine learning to neuroimaging, natural language processing, and time series analysis. The second part provides an overview of some state-of-the-art applications of these methodologies. The Machine Intelligence in Clinical Neuroscience (MICN) Laboratory at the Department of Neurosurgery of the University Hospital Zurich studies clinical applications of machine intelligence to improve patient care in clinical neuroscience. The group focuses on diagnostic, prognostic and predictive analytics that aid in decision-making by increasing objectivity and transparency to patients. Other major interests of our group members are in medical imaging, and intraoperative applications of machine vision.

This book constitutes the refereed proceedings of the Third International Workshop on Machine Learning in Clinical Neuroimaging, MLCN 2020, and the Second International Workshop on Radiogenomics in Neuro-oncology, RNO-AI 2020, held in conjunction with MICCAI 2020, in Lima, Peru, in October 2020.* For MLCN 2020, 18 papers out of 28 submissions were accepted for publication. The accepted papers present novel contributions in both developing new machine learning methods and applications of existing methods to solve challenging problems in clinical neuroimaging. For RNO-AI 2020, all 8 submissions were accepted for publication. They focus on addressing the problems of applying machine learning to large and multi-site clinical neuroimaging datasets. The workshop aimed to bring together experts in both machine learning and clinical neuroimaging to discuss and hopefully bridge the existing challenges of applied machine learning in clinical neuroscience. *The workshops were held virtually due to the COVID-19 pandemic.

This book constitutes the refereed proceedings of the 5th International Workshop on Machine Learning in Clinical Neuroimaging, MLCN 2022, held in Conjunction with MICCAI 2022, Singapore in September 2022. The book includes 17 papers which were carefully reviewed and selected from 23 full-length submissions. The 5th international workshop on Machine Learning in Clinical Neuroimaging (MLCN2022) aims to bring together the top researchers in both machine learning and clinical neuroscience as well as tech-savvy clinicians to address two main challenges: 1) development of methodological approaches for analyzing complex and heterogeneous neuroimaging data (machine learning track); and 2) filling the translational gap in applying existing machine learning methods in clinical practices (clinical neuroimaging track). The papers are categorzied into topical sub-headings: Morphometry; Diagnostics, and Aging, and Neurodegeneration.

Machine Learning is an area of artificial intelligence involving the development of algorithms to discover trends and patterns in existing data; this information can then be used to make predictions on new data. A growing number of researchers and clinicians are using machine learning methods to develop and validate tools for assisting the diagnosis and treatment of patients with brain disorders. Machine Learning: Methods and Applications to Brain Disorders provides an up-to-date overview of how these methods can be applied to brain disorders, including both psychiatric and neurological disease. This book is written for a non-technical audience, such as neuroscientists, psychologists, psychiatrists, neurologists and health care practitioners. - Provides a non-technical introduction to machine learning and applications to brain disorders - Includes a detailed description of the most commonly used machine learning algorithms as well as some novel and promising approaches - Covers the main methodological challenges in the application of machine learning to brain disorders - Provides a step-by-step tutorial for implementing a machine learning pipeline to neuroimaging data in Python

This book constitutes the refereed proceedings of the 6th International Workshop on Machine Learning in Clinical Neuroimaging, MLCN 2023, held in Conjunction with MICCAI 2023 in Vancouver, Canada, in October 2023. The book includes 16 papers which were carefully reviewed and selected from 28 full-length submissions. The 6th International Workshop on Machine Learning in Clinical Neuroimaging (MLCN 2023) aims to bring together the top researchers in both machine learning and clinical neuroscience as well as tech-savvy clinicians to address two main challenges: 1) development of methodological approaches for analyzing complex and heterogeneous neuroimaging data (machine learning track); and 2) filling the translational gap in applying existing machine learning methods in clinical practices (clinical neuroimaging track). The papers are categorzied into topical sub-headings on Machine Learning and Clinical Applications.

Big Data in Psychiatry and Neurology provides an up-to-date overview of achievements in the field of big data in Psychiatry and Medicine, including applications of big data methods to aging disorders (e.g., Alzheimer's disease and Parkinson's disease), mood disorders (e.g., major depressive disorder), and drug addiction. This book will help researchers, students and clinicians implement new methods for collecting big datasets from various patient populations. Further, it will demonstrate how to use several algorithms and machine learning methods to analyze big datasets, thus providing individualized treatment for psychiatric and neurological patients. As big data analytics is gaining traction in psychiatric research, it is an essential component in providing predictive models for both clinical practice and public health systems. As compared with traditional statistical methods that provide primarily average group-level results, big data analytics allows predictions and stratification of clinical outcomes at an individual subject level. - Discusses longitudinal big data and risk factors surrounding the development of psychiatric disorders - Analyzes methods in using big data to treat psychiatric and neurological disorders - Describes the role machine learning can play in the analysis of big data - Demonstrates the various methods of gathering big data in medicine - Reviews how to apply big data to genetics

This Open Access volume provides readers with an up-to-date and comprehensive guide to both methodological and applicative aspects of machine learning (ML) for brain disorders. The chapters in this book are organized into five parts. Part One presents the fundamentals of ML. Part Two looks at the main types of data used to characterize brain disorders, including clinical assessments, neuroimaging, electro- and magnetoencephalography, genetics and omics data, electronic health records, mobile devices, connected objects and sensors. Part Three covers the core methodologies of ML in brain disorders and the latest techniques used to study them. Part Four is dedicated to validation and datasets, and Part Five discusses applications of ML to various neurological and psychiatric disorders. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting, Machine Learning for Brain Disorders is a valuable resource for researchers and graduate students who are new to this field, as well as experienced researchers who would like to further expand their knowledge in this area. This book will be useful to students and researchers from various backgrounds such as engineers, computer scientists, neurologists, psychiatrists, radiologists, and neuroscientists.