"The impact of the M1 tank cannot be overstated; while applying lessons learned from mistakes of the past, this new tank defined tanks and armored warfare for the foreseeable future. It redefined how the U.S. Army thought, planned, trained, and fought. The M1 carried the army into an order-of-magnitude change that ran the gamut of ground warfare. The speed that the army moved across the battlefield was increased, the methods used to supply this faster-moving force were redefined and mastered, the methods used to provide supporting fire from artillery and close-air-support aircraft were redefined and mastered, and the decision-making process used by the leadership at virtually all levels was accelerated. For the first time in history, the U.S. Army had the best tank in the world. The M1 Abrams became the yardstick for foreign countries potential enemies, and friends alike, to measure the capabilities of their own tanks ... the M1 embodied what arguably may be the ultimate balance of the three classic tank design criteria - firepower, mobility, and protection"--Introduction.

The M1 Garand gave the US infantryman a marked edge during World War II. It shot faster and further than enemy infantry rifles and hit harder. No less an authority on killing the enemy than General George S. Patton called the Garand, “The greatest battle implement ever devised.” At a time when opposing forces were armed with bolt-action rifles, US troops had a highly reliable self-loader. The eight-round clips which were used to load the M1 Garand were, however, viewed with mixed emotions by the troops on the ground. Some Army and Marine Corps troops allegedly felt that the distinctive “twang” as the Garand's clip was ejected when empty alerted the enemy that the soldiers were reloading and resulted in an attack. But the Garand became the defining mankiller of the war, despite its weight and magazine problems, and many US combat veterans consider it one of the key reasons they survived the war.

Extensive excavations by MOLA (Museum of London Archaeology) near Houghton Regis and Toddington, in south Central Bedfordshire, provide a detailed multi-period dataset for regional and national comparison. Evidence ranges from middle/late Bronze Age pits to medieval settlements.

In 1938 the US Chief of Infantry requested that the Ordnance Department develop a carbine to be used by service and support troops, artillerymen, machine-gun crews, tankers, mortar crews and other troops not needing the power of the M1 Garand rifle. The development of this new weapon was given an added impetus by Germany's successful use of airborne and glider troops early on in World War II. This caused a fear amongst US officers that troops normally considered 'behind the lines' personnel might have to fight elite German troops and would therefore require a more effective weapon than their standard pistols. The resulting M1 Carbine was a not a shortened version of the standard service rifle but instead a brand-new design chambering a new cartridge. Eventually numerous manufacturers would combine to produce over six million M1 Carbines before the end of the war. This book charts the complete story of the weapon, from its design, to its operational history and its impact upon warfare.

Macrophages have unique and diverse functions necessary for survival. And, in humans (and other species), they are the most abundant leukocytes in tissues. The Innate functions of macrophages that are best known are their unusual ability to either “Kill” or “Repair”. Since killing is a destructive process and repair is a constructive process, it was stupefying how one cell could exhibit these 2 polar – opposite functions. However, in the late 1980’s, it was shown that macrophages have a unique ability to enzymatically metabolize Arginine to Nitric Oxide (NO, a gaseous non – specific killer molecule) or to Ornithine (a precursor of polyamines and collagen for repair). The dual Arginine metabolic capacity of macrophages provided a functional explanation for their ability to kill or repair. Macrophages predominantly producing NO are called M1 and those producing Ornithine are called M2. M1 and M2 – dominant responses occur in lower vertebrates, and in T cell deficient vertebrates being directly driven by Damage and Pathogen Associated Molecular Patterns (DAMP and PAMP). Thus, M1 and M2 are Innate responses that protect the host without Adaptive Immunity. In turn, M1/M2 is supplanting previous models in which T cells were necessary to “activate” or “alternatively activate” macrophages (the Th1/Th2 paradigm). M1 and M2 macrophages were named such because of the additional key findings that these macrophages stimulate Th1 and Th2 – like responses, respectively. So, in addition to their unique ability to kill or repair, macrophages also govern Adaptive Immunity. All of the foregoing would be less important if M1 or M2 – dominant responses were not observed in disease. But, they are. The best example to date is the predominance of M2 macrophages in human tumors where they act like wound repair macrophages and actively promote growth. More generally, humans have become M2 – dominant because sanitation, antibiotics and vaccines have lessened M1 responses. And, M2 dominance seems the cause of ever - increasing allergies in developed countries. Obesity represents a new and different circumstance. Surfeit energy (e.g., lipoproteins) causes monocytes to become M1 dominant in the vessel walls causing plaques. Because M1 or M2 dominant responses are clearly causative in many modern diseases, there is great potential in developing the means to selectively stimulate (or inhibit) either M1 or M2 responses to kill or repair, or to stimulate Th1 or Th2 responses, depending on the circumstance. The contributions here are meant to describe diseases of M1 or M2 dominance, and promising new methodologies to modulate the fungible metabolic machinery of macrophages for better health.