This book is part of a two-volume work that constitutes the refereed proceedings of the International Conference on Life System Modeling and Simulation, LSMS 2007, held in Shanghai, China, September 2007. Coverage includes modeling and simulation of societies and collective behavior, computational methods and intelligence in biomechanical systems, tissue engineering and clinical bioengineering, computational intelligence in bioinformatics and biometrics, and brain stimulation.

This easy to read text provides a broad introduction to the fundamental concepts of modeling and simulation (M&S) and systems engineering, highlighting how M&S is used across the entire systems engineering lifecycle. Features: reviews the full breadth of technologies, methodologies and uses of M&S, rather than just focusing on a specific aspect of the field; presents contributions from specialists in each topic covered; introduces the foundational elements and processes that serve as the groundwork for understanding M&S; explores common methods and methodologies used in M&S; discusses how best to design and execute experiments, covering the use of Monte Carlo techniques, surrogate modeling and distributed simulation; explores the use of M&S throughout the systems development lifecycle, describing a number of methods, techniques, and tools available to support systems engineering processes; provides a selection of case studies illustrating the use of M&S in systems engineering across a variety of domains.

This book constitutes the first part of the refereed proceedings of the International Conference on Life System Modeling and Simulation, LSMS 2014, and of the International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2014, held in Shanghai, China, in September 2014. The 159 revised full papers presented in the three volumes of CCIS 461-463 were carefully reviewed and selected from 572 submissions. The papers of this volume are organized in topical sections on biomedical signal processing, imaging, and visualization; computational methods and intelligence in modeling genetic and chemical networks and regulation; computational methods and intelligence in organism modeling; computational methods and intelligence in modeling and design of synthetic biological systems; computational methods and intelligence in biomechanical systems, tissue engineering and clinical bioengineering; intelligent medical apparatus and clinical applications; modeling and simulation of societies and collective behaviour; innovative education in systems modeling and simulation; data analysis and data mining of biosignals; feature selection; robust optimization and data analysis.

The 2010 International Conference on Life System Modeling and Simulation (LSMS 2010) and the 2010 International Conference on Intelligent Computing for Sustainable Energy and Environment (ICSEE 2010) were formed to bring together researchers and practitioners in the fields of life system modeling/simulation and intelligent computing applied to worldwide sustainable energy and environmental applications. A life system is a broad concept, covering both micro and macro components ra- ing from cells, tissues and organs across to organisms and ecological niches. To c- prehend and predict the complex behavior of even a simple life system can be - tremely difficult using conventional approaches. To meet this challenge, a variety of new theories and methodologies have emerged in recent years on life system modeling and simulation. Along with improved understanding of the behavior of biological systems, novel intelligent computing paradigms and techniques have emerged to h- dle complicated real-world problems and applications. In particular, intelligent c- puting approaches have been valuable in the design and development of systems and facilities for achieving sustainable energy and a sustainable environment, the two most challenging issues currently facing humanity. The two LSMS 2010 and ICSEE 2010 conferences served as an important platform for synergizing these two research streams.

This book is part I of a two-volume work that contains the refereed proceedings of the International Conference on Life System Modeling and Simulation, LSMS 2010 and the International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2010, held in Wuxi, China, in September 2010. The 194 revised full papers presented were carefully reviewed and selected from over 880 submissions and recommended for publication by Springer in two volumes of Lecture Notes in Computer Science (LNCS) and one volume of Lecture Notes in Bioinformatics (LNBI). This particular volume of Lecture Notes in Computer Science (LNCS) includes 55 papers covering 7 relevant topics. The 55 papers in this volume are organized in topical sections on intelligent modeling, monitoring, and control of complex nonlinear systems; autonomy-oriented computing and intelligent agents; advanced theory and methodology in fuzzy systems and soft computing; computational intelligence in utilization of clean and renewable energy resources; intelligent modeling, control and supervision for energy saving and pollution reduction; intelligent methods in developing vehicles, engines and equipments; computational methods and intelligence in modeling genetic and biochemical networks and regulation.

This user’s reference is a companion to the separate book also titled “Guide to Modelling and Simulation of Systems of Systems.” The principal book explicates integrated development environments to support virtual building and testing of systems of systems, covering in some depth the MS4 Modelling EnvironmentTM. This user’s reference provides a quick reference and exposition of the various concepts and functional features covered in that book. The topics in the user’s reference are grouped in alignment with the workflow displayed on the MS4 Modeling EnvironmentTM launch page, under the headings Atomic Models, System Entity Structure, Pruning SES, and Miscellaneous. For each feature, the reference discusses why we use it, when we should use it, and how to use it. Further comments and links to related features are also included.

This book develops the mathematical tools essential for students in the life sciences to describe interacting systems and predict their behavior. From predator-prey populations in an ecosystem, to hormone regulation within the body, the natural world abounds in dynamical systems that affect us profoundly. Complex feedback relations and counter-intuitive responses are common in nature; this book develops the quantitative skills needed to explore these interactions. Differential equations are the natural mathematical tool for quantifying change, and are the driving force throughout this book. The use of Euler’s method makes nonlinear examples tractable and accessible to a broad spectrum of early-stage undergraduates, thus providing a practical alternative to the procedural approach of a traditional Calculus curriculum. Tools are developed within numerous, relevant examples, with an emphasis on the construction, evaluation, and interpretation of mathematical models throughout. Encountering these concepts in context, students learn not only quantitative techniques, but how to bridge between biological and mathematical ways of thinking. Examples range broadly, exploring the dynamics of neurons and the immune system, through to population dynamics and the Google PageRank algorithm. Each scenario relies only on an interest in the natural world; no biological expertise is assumed of student or instructor. Building on a single prerequisite of Precalculus, the book suits a two-quarter sequence for first or second year undergraduates, and meets the mathematical requirements of medical school entry. The later material provides opportunities for more advanced students in both mathematics and life sciences to revisit theoretical knowledge in a rich, real-world framework. In all cases, the focus is clear: how does the math help us understand the science?