Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Provides an introduction to American pulp fiction during the twentieth century with brief author biographies and lists of their works.

Featuring a number of pioneering essays by the internationally known Russian cultural historians Boris Uspenskij and Victor Zhivov, this collection includes a number of essays appearing in English for the fi rst time. Focusing on several of the most interesting and problematic aspects of Russia's cultural development, these essaysexamine the survival and the reconceptualization of the past in later cultural systems and some of the key transformations of Russian cultural consciousness. The essays in this collection contain some important examples of Russian cultural semiotics and remain indispensable contributions to the history of Russian civilization.