Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.

An easy-to-use dictionary of over 80,000 rhyming words.

Bound Lives chronicles the lived experience of race relations in northern coastal Peru during the colonial era. Rachel Sarah O'Toole examines how Andeans and Africans negotiated and employed casta, and in doing so, constructed these racial categories. Royal and viceregal authorities separated "Indians" from "blacks" by defining each to specific labor demands. Casta categories did the work of race, yet, not all casta categories did the same type of work since Andeans, Africans, and their descendants were bound by their locations within colonialism and slavery. The secular colonial legal system clearly favored indigenous populations. Andeans were afforded greater protections as "threatened" native vassals. Despite this, in the 1640s during the rise of sugar production, Andeans were driven from their assigned colonial towns and communal property by a land privatization program. Andeans did not disappear, however; they worked as artisans, muleteers, and laborers for hire. By the late seventeenth and early eighteenth centuries, Andeans employed their legal status as Indians to defend their prerogatives to political representation that included the policing of Africans. As rural slaves, Africans often found themselves outside the bounds of secular law and subject to the judgments of local slaveholding authorities. Africans therefore developed a rhetoric of valuation within the market and claimed new kinships to protect themselves in disputes with their captors and in slave-trading negotiations. Africans countered slaveholders' claims on their time, overt supervision of their labor, and control of their rest moments by invoking customary practices. Bound Lives offers an entirely new perspective on racial identities in colonial Peru. It highlights the tenuous interactions of colonial authorities, indigenous communities, and enslaved populations and shows how the interplay between colonial law and daily practice shaped the nature of colonialism and slavery.