Visceral leishmaniasis (VL), (also known as black fever or Kala-azar) is a life-threatening disease first reported from the Indian subcontinent. VL ranks as the world’s second largest parasitic disease killer and is a neglected tropical disease. Most of those infected by this life-threatening disease are uneducated daily wagers working to support their families, and vectors easily disseminate the disease to their neighbors. Owing to recent involvement of stakeholders, the number of patients is decreasing, but eradication remains a distant goal. This second edition presents latest reports of visceral Leishmaniasis by specialists working at the forefront of the endemic areas in Indian subcontinent. It also introduces vaccine development and inhibitors to Trypanosomatidae; some of them describing feasibility studies in visceral Leishmaniasis for the first time. Recent progress of the Science and Technology Research Partnership for Sustainable Development (SATREPS) is also reviewed and the contents share this collaborative research from the forefront of endemic sites in Bangladesh. Widely covering basic, clinical, epidemiological and entomological aspects, this volume will be of great interest to dedicated researchers interested inLeishmaniasis and to experts of NTDs in global health. There is a tide in the affairs of men. Which, taken at the flood, leads on to fortune; Omitted, all the voyage of disease control is bound in shallows and in miseries. ~modified from Shakespeare ~

Therapeutic regimens for visceral leishmaniasis (also Kala-azar, Dum-dum fever or black fever), caused by parasitic protozoa of the Leishmania genus, evolve at a pace never seen before. Spread by tiny and abundant sand flies, the parasite infects internal organs and bone marrow and if left untreated will almost always result in the death of the host. In developing countries successful diagnosis and treatment are complicated by asymptomatic cases, undernutrition and Kala-azar/HIV co-infections. This book brings together world-renown experts writing state-of-arts review on the progress in diagnosis and treatment of visceral leishmaniasis, ultimately leading to the complete elimination of this fatal disease from South Asia. The chapters provide valuable information for disease control as well as therapy and the diagnostic improvements necessary for early treatment, subclinical detection and drug-resistant cases. The presented methods allow for points-of-care testing in the endemic area, enabling rapid detection in resource-poor settings with easy handling and low costs. This book provides essential information for scientists, medical practitioners and policy makers involved in the diagnosis, treatment and elimination of Kala-azar.

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This book addresses the current challenges in controlling Kala-azar disease (Visceral leishmaniasis) in India and other VL-endemic areas, and aims to develop and apply a geo-environmental risk model based on primary and secondary data with the aid of remote sensing and GIS technologies to assess and mitigate Kala-azar transmission. Through case studies carried out in India, the book provides insight into the relationship between geo-environmental variables and encroachments of Kala-azar, and identifies potential pathways for VL introduction to develop mitigation strategies using GIS and remote sensing technologies. The book critically assesses existing VL mitigation measures that do not adequately account for geo-environmental conditions, and analyzes the environmental factors that aid Kala-azar transmission using remote sensing, spatial statistics and data mining techniques. The book will be of interest to epidemiologists, researchers and practitioners using geospatial data practices to study disease transmission and associated monitoring technologies.

Delve into the urgent and compelling narrative of "Tackling the Kala-Azar Menace in Bihar" by Ganga Kumar and Ragini Mishra, a groundbreaking exploration of one of India's most pressing public health challenges. Prepare to be enlightened and inspired by the tireless efforts of those on the front lines of the fight against this devastating disease. Follow the insightful analysis of Kumar and Mishra as they shine a spotlight on the deadly threat of Kala-Azar and the efforts being made to combat its spread in the state of Bihar. Through their meticulous research and compassionate storytelling, readers are given a firsthand glimpse into the struggles and triumphs of those working to eradicate this ancient scourge. Themes of resilience, innovation, and the power of collective action permeate "Tackling the Kala-Azar Menace in Bihar," offering readers a profound insight into the challenges and opportunities facing public health initiatives in India. Kumar and Mishra's compassionate portrayal sheds light on the human cost of the disease and the efforts being made to save lives and alleviate suffering. Characterized by its rigorous analysis and heartfelt empathy, "Tackling the Kala-Azar Menace in Bihar" immerses readers in the complex world of disease control and prevention, where every breakthrough brings hope and every setback serves as a reminder of the work that remains to be done. Kumar and Mishra's vivid descriptions and vivid characterizations bring to life the tireless efforts of health workers, researchers, and policymakers as they strive to overcome formidable obstacles. Since its publication, "Tackling the Kala-Azar Menace in Bihar" has been hailed as a seminal work in the field of public health research, shedding light on an often-overlooked aspect of India's healthcare system. Kumar and Mishra's comprehensive analysis and compassionate storytelling offer readers a deeper understanding of the challenges facing communities affected by Kala-Azar and the strategies being employed to combat its spread. As you delve into the pages of "Tackling the Kala-Azar Menace in Bihar," you'll find yourself inspired by the resilience and determination of those working to eradicate this devastating disease. Kumar and Mishra's groundbreaking research is a testament to the power of knowledge and collaboration to effect positive change in the world. Don't miss your chance to learn more about the fight against Kala-Azar in Bihar. Let Ganga Kumar and Ragini Mishra's insightful exploration inspire you to join the global effort to eliminate this ancient scourge. Grab your copy now and become part of the solution to one of India's most pressing public health challenges.

​Leishmania-related illnesses remain among the world’s deadliest neglected tropical diseases, affecting approximately 12 million people in 88 countries. The mortality rate is substantial, contributing to nearly two million disability-adjusted life years. As more is understood about this parasite and its effects, work toward prevention, control, and treatment continues apace. Leishmania and Leishmaniasis will address the parasite and its attendant disease, which manifests in three syndromes: Visceral (VL), Cutaneous (CL) and Mucocutaneous Leishmaniasis (ML). The morphology and life cycles of the various species will be among the topics addressed in Part One. Part Two will focus on immunology, including host-immune response to Leishmania infection, cross-immunity between the different species and adoptive transfer of immunity. Parts Three and Four will address how Leishmania invade and survive, the clinical features of the disease, and its diagnosis. Drugs, vaccines and treatment will be thoroughly explored, including experimental models of therapeutics. Leishmania and Leishmaniasis will provide a thorough examination of a parasite, the illnesses it causes and the misery it continues to visit upon large segments of the population.​