INTERNATIONAL BESTSELLER • A bestselling dystopian novel that tackles surveillance, privacy and the frightening intrusions of technology in our lives—a “compulsively readable parable for the 21st century” (Vanity Fair). When Mae Holland is hired to work for the Circle, the world’s most powerful internet company, she feels she’s been given the opportunity of a lifetime. The Circle, run out of a sprawling California campus, links users’ personal emails, social media, banking, and purchasing with their universal operating system, resulting in one online identity and a new age of civility and transparency. As Mae tours the open-plan office spaces, the towering glass dining facilities, the cozy dorms for those who spend nights at work, she is thrilled with the company’s modernity and activity. There are parties that last through the night, there are famous musicians playing on the lawn, there are athletic activities and clubs and brunches, and even an aquarium of rare fish retrieved from the Marianas Trench by the CEO. Mae can’t believe her luck, her great fortune to work for the most influential company in the world—even as life beyond the campus grows distant, even as a strange encounter with a colleague leaves her shaken, even as her role at the Circle becomes increasingly public. What begins as the captivating story of one woman’s ambition and idealism soon becomes a heart-racing novel of suspense, raising questions about memory, history, privacy, democracy, and the limits of human knowledge.

This volume summarizes the state-of-the-art in the fast growing research area of modeling the influence of information-driven human behavior on the spread and control of infectious diseases. In particular, it features the two main and inter-related “core” topics: behavioral changes in response to global threats, for example, pandemic influenza, and the pseudo-rational opposition to vaccines. In order to make realistic predictions, modelers need to go beyond classical mathematical epidemiology to take these dynamic effects into account. With contributions from experts in this field, the book fills a void in the literature. It goes beyond classical texts, yet preserves the rationale of many of them by sticking to the underlying biology without compromising on scientific rigor. Epidemiologists, theoretical biologists, biophysicists, applied mathematicians, and PhD students will benefit from this book. However, it is also written for Public Health professionals interested in understanding models, and to advanced undergraduate students, since it only requires a working knowledge of mathematical epidemiology.

This unique book is a serious study of clinical endodontics that underscores the biologic foundation of endodontic treatment and seeks to bridge the gap between basic endodontic knowledge and advanced endodontic biology. Written by a well-established clinician and a researcher with extensive background in endodontic microbiology, this book combines invaluable histologic illustrations of endodontic disease with a robust clinical text that (1) describes the pathologies affecting dental tissues as well as their reactions to the clinical procedures and (2) uses clinical microbiology to explain the observed phenomena. Treatments of complex endodontic infections are presented for both vital and nonvital pulp therapy, and the influence of periradicular pathology are addressed in detail. Moreover, the authors wade into controversial topics with detailed and comprehensive analysis, including the implications of lateral canals on treatment and the causes of treatment failures and how to avoid them. The purpose of this book is to improve endodontic treatment, and the authors demonstrate how an in-depth knowledge of endodontic infections can help clinicians to synthesize the data from patient examinations in order to visualize what has taken place, understand the processes at work, and predict what will occur with the patient. An essential clinical text for comprehensive endodontic study.

Endodontic pain is a complex symptom that poses unique challenges for the dentist. This book is a concise, well-structured guide to the assessment and treatment of patients who present with endodontic pain, in which step-by-step descriptions are complemented by informative images and flow charts. The advantages, disadvantages, and significance of specific diagnostic and treatment procedures are clearly described, as is a pharmacotherapeutic approach to the prevention and treatment of pain. In addition, the causes and biological basis of endodontic pain are explained and guidance is provided on further strategies for pain prevention. The crisp narrative, efficient design and visual detail are notable features of this book that will make it an ideal chairside resource for the clinician and a dependable reference for the student.

This volume describes culture media and solutions used in human ART; how they have been developed for in vitro human pre-implantation embryo development, the function and importance of the various components in media and solutions and how they interact, and how the systems in which these are used can influence outcomes. Chapters discuss inorganic solutes, energy substrates, amino acids, macromolecules, cytokines, growth factors, buffers, pH, osmolality, and the interaction of these parameters. The role of incubators and other physical factors are reviewed, along with the relevance and prospects of emerging technologies: morphokinetic analysis using time-lapse imaging and dynamic fluid incubation systems. Results of prospective randomized trials are emphasized to ascertain the added value of these techniques for selecting viable embryos. This comprehensive guide will be invaluable for embryologists, physicians and all personnel involved in the fluid products used in human ART seeking to optimize their successful use of these components.

Ideas and information that can enhance education about the constitutional rights of individuals in U.S. history and the current system of government in the United States are included in this book. The resource guide contains nine distinct parts dealing with aspects of learning and teaching about the Bill of Rights in both elementary and secondary schools. Part I, Background Papers, features four essays for teachers on the origins, enactment, and development of the federal Bill of Rights. A fifth paper discusses the substance and strategies for teaching Bill of Rights topics and issues. Part II, A Bill of Rights Chronology, is a timetable of key dates and events in the making of the federal Bill of Rights. Part III, Documents, includes 11 primary sources about the origins, enactment, and substance of the federal Bill of Rights. Part IV, Lessons on the Bill of Rights, consists of nine exemplary lessons. The remaining five parts include: Papers in ERIC on Constitutional Rights; Select Annotated Bibliography of Curriculum Materials; Periodical Literature on Teaching the Bill of Rights; Bill of Rights Bookshelf for Teachers; and Directory of Key Organizations and Persons. (DB)