A biography of the man who invented the heart-lung machine, making modern heart surgery possible.

John Heysham Gibbon, Jr., M.D., was the first researcher to develop a heart-lung machine that could fully support an adult's cardiac and respiratory functions during surgical procedures to repair defects in the heart and lungs. The difficulty of such a task can be seen in the number of people who attempted it for over a century: the list is long. Gibbon succeeded on May 6, 1953, when he repaired an atrial-septal defect with the patient supported entirely by the machine for 27 minutes. Ada Romaine-Davis contends that few realize how long Gibbon worked to achieve this success. To rectify the situation, Romaine-Davis here provides a thorough study of Gibbon and his accomplishment. She shows how Gibbon overcame discouragement from his peers and mentors and obtained crucial support from IBM Board Chairman Thomas Watson. She examines each of the models produced by Gibbon and puts his achievement into historical perspective. Gibbon himself chose not to pursue cardiac surgery; he remained a thoracic surgeon. Others went on to develop the knowledge and skills that today make open-heart surgery as safe as other major surgical procedures. As Romaine-Davis amply demonstrates, these pioneers stand on the shoulders of a stubborn, persevering, single-minded genius whose determination to leave a legacy to his profession resulted in the one thing essential for sustained progress in heart surgery: John Gibbon's heart-lung machine. This meticulously researched study will make fascinating reading for physicians—especially surgeons—as well as for students and scholars of medical history and science and technology.

This edition includes 90% new material reflecting advances in the field, covering natural history and diagnosis, new trends and new operations. It has more detailed information about standard operations and still covers indications and outcomes for all types of surgery.

Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.

Since the publication of the first edition of Core Topics in Cardiac Anaesthesia, the clinical landscape has undergone significant change. Recent developments include the increased use of electrophysiology, the resurgence of primary percutaneous intervention in acute coronary syndromes, the use of percutaneous devices in patients previously considered inoperable, and the withdrawal of aprotinin. Against this landscape, this invaluable resource has been fully updated. New chapters are dedicated to right heart valves, pulmonary vascular disease, cardiac tumours and cardiac trauma. All other chapters have been updated according to the latest international guidelines. Written and edited by an international author team with a wealth of expertise in all aspects of the perioperative care of cardiac patients, topics are presented in an easy to digest and a readily accessible manner. Core Topics in Cardiac Anaesthesia, Second Edition is essential reading for residents and fellows in anaesthesia and cardiac surgery and clinical perfusionists.

The clinical practice of anesthesia has undergone many advances in the past few years, making this the perfect time for a new state-of-the-art anesthesia textbook for practitioners and trainees. The goal of this book is to provide a modern, clinically focused textbook giving rapid access to comprehensive, succinct knowledge from experts in the field. All clinical topics of relevance to anesthesiology are organized into 29 sections consisting of more than 180 chapters. The print version contains 166 chapters that cover all of the essential clinical topics, while an additional 17 chapters on subjects of interest to the more advanced practitioner can be freely accessed at www.cambridge.org/vacanti. Newer techniques such as ultrasound nerve blocks, robotic surgery and transesophageal echocardiography are included, and numerous illustrations and tables assist the reader in rapidly assimilating key information. This authoritative text is edited by distinguished Harvard Medical School faculty, with contributors from many of the leading academic anesthesiology departments in the United States and an introduction from Dr S. R. Mallampati. This book is your essential companion when preparing for board review and recertification exams and in your daily clinical practice.

Cardiopulmonary Bypass, 2nd edition, offers a complete introduction to this specialist technique for medical and technical personnel involved in extracorporeal cardiopulmonary support. A clinically based overview of the subject is provided and updated chapters incorporate the most current developments in the field. Introductory chapters cover equipment and preparation of the cardiopulmonary bypass machine, safety and monitoring, routine conduct of bypass, and the process of weaning from mechanical to physiological circulation. Specialist chapters on mechanical support, ECMO, special surgical procedures, blood conservation techniques, and particular medical conditions that affect the conduct of cardiopulmonary bypass are also included. This new edition includes self-assessment multiple choice questions at the end of each chapter, allowing readers to test their own understanding of the material. Written and edited by specialists from leading cardiac centres in the UK and USA, this is an invaluable resource for clinical perfusion scientists, cardiac surgeons and cardiothoracic anaesthetists in training.