Isotope Dilution Mass Spectrometry (IDMS) has become an essential tool in research laboratories and is increasingly used in routine analysis labs (including environmental, food safety and clinical applications). This is the first textbook to present a comprehensive and instructive view of the theory and applications of this growing technique. The main objective of this book is to cover the theory and applications of Isotope Dilution in Analytical Chemistry. The scope is comprehensive to include elemental analysis, speciation analysis, organic analysis and biochemical and clinical analysis together with applications in metabolism studies and traceability of goods. Until now there have been no books published with the same general scope (only book chapters on particular applications). This is a textbook focused at post-graduate level covering the basic knowledge required for doctoral studies in this field. Isotope Dilution Mass Spectrometry will also outline practical applications of interest for routine testing laboratories where isotope dilution procedures are implemented or can be implemented in the future. This unique book covers all the theoretical and practical aspects of Isotope Dilution Mass Spectrometry (IDMS). Due to the increasing application of IDMS in many research laboratories and the increasing implementation of IDMS methodologies in routine testing laboratories, scientists in industry and working in or affiliated to this area will this an invaluable source of information. Concerning the theoretical aspects, the authors present a uniform theoretical background which grows from previous developments in Organic, Speciation and Elemental analysis both in their own laboratory and in other laboratories around the world. This general approach will be simpler and will also include new emerging fields such as quantitative proteomics and metabolism studies.

International Series of Monographs in Analytical Chemistry, Volume 49: Isotope Dilution Analysis focuses on the method of isotope dilution analysis (IDA). The book first discusses the principles, types, and theory of IDA. Classification of the methods of IDA; precision, accuracy, and sensitivity of IDA; and types of IDA are described. The text also examines experimental techniques, separation, and mass determination. The separation of components, reagents and tracers, and amount of substance separated are underscored. The text takes a look at the inorganic applications of IDA, including determination of elements and selected procedures. The text examines the applications of IDA in organic chemistry and biochemistry, particularly in the analysis of alcohols and ethers, steroids, penicillin, proteins and amino acids, and insecticides. The book discusses IDA with stable isotopes. Methods for the determination of isotopic composition, fundamentals and technique, and practical applications are underscored. The text also emphasizes the special applications of isotope dilution. Determination of the content of isotopic carriers in radioactive preparations; determination of the coefficient of self-absorption and specific activity; and determination of radioactive contaminants are discussed. The text is a vital reference for readers interested in isotope dilution analysis.

The isotope dilution mass spectrometry (IDMS) technique is well known and widely reported in the literature. However, its application can present considerable difficulties with regard to obtaining reliable results. Produced jointly by the Royal Society of Chemistry's Analytical Methods Committee and the Valid Analytical Measurement (VAM) programme, the aim of this book is to provide a simplified yet robust methodology, together with adequate guidance, to enable laboratories wishing to use the technique to obtain reliable data. The methodologies, for inorganic and organic mass spectrometry, which use exact and approximate matching, are illustrated with worked examples and clear diagrammatic representations. A comprehensive glossary of terms, references to key publications and an extensive IDMS bibliography are also provided. Clear and comprehensive in coverage, Guidelines for Achieving High Accuracy in Isotope Dilution Mass Spectrometry (IDMS) will provide valuable assistance to a wide variety of analytical chemists interested in applying the IDMS technique to their own measurement applications.

Edited by two very well-known and respected scientists in the field, this excellent practical guide is the first to cover the fundamentals and a wide range of applications, as well as showing readers how to efficiently use this increasingly important technique. From the contents: * The Isotopic Composition of the Elements * Single-Collector ICP-MS * Multi-Collector ICP-MS * Advances in Laser Ablation - Multi-Collector ICP-MS * Correction for Instrumental Mass Discrimination in Isotope Ratio Determination with Multi-Collector ICP-MS * Reference Materials in Isotopic Analysis * Quality Control in Isotope Ratio Applications * Determination of Trace Elements and Elemental Species Using Isotope Dilution ICP-MS * Geochronological Dating * Application of Multi-Collector ICP-MS to Isotopic Analysis in Cosmochemistry * Establishing the Basis for Using Stable Isotope Ratios of Metals as Paleoredox Proxies * Isotopes as Tracers of Elements Across the Geosphere-Biosphere Interface * Archaeometric Applications * Forensics Applications * Nuclear Applications * The Use of Stable Isotope Techniques for Studying Mineral and Trace Element Metabolism in Humans * Isotopic Analysis via Multi-Collector ICP-MS in Elemental Speciation A must-have for newcomers as well as established scientists seeking an overview of isotopic analysis via ICP-MS.

Determination of Toxic Organic Chemicals in Natural Waters, Sediments and Soils: Determination and Analysis reviews the latest techniques for the determination and assessment of both current and emerging organic compounds in a range of important environmental contexts. A wide range of organic compounds in non-saline waters are discussed in the opening chapters, including hydrocarbons, surface active agents and volatile organic compounds. This is followed by multiorganics, pesticides and organometallic compounds in non-saline waters. Organic compounds in aqueous precipitation are then explored before the book goes on to discuss compounds in soils, including extraction techniques, insecticides, herbicides and fungicides, and organometallic compounds. Finally, the concluding chapters focus on compounds in sediments, providing readers with the latest information in the field and supporting them as they address the important issue surrounding organic material throughout ecosystems. - Highlights the latest methods for analyzing a wide range of organic compounds - Supports researchers by providing detailed information across a range of ecosystems - Includes detailed guidance for assessing complex mixtures of organic compounds in the environment