Document from the year 2020 in the subject Chemistry - Macromolecular Chemistry, Polymer Chemistry, grade: 2, , language: English, abstract: This work gives an overview over core modified Porphyrinoids. Specifically: Smaragdyrins, Expanded Porphyrinoids and Corroles. It does so by, in two chapters, defining each of the aforementioned chemical combinations ́ synthesis and characterization, properties and respective dyads. Smaragdyrin is a pentapyrrolic 22π-electron expanded porphyrin system bearing two direct pyrrole-pyrrole bonds. This macrocycle and its core modified derivative i.e. 25-oxasmaragdyrin have received upsurge interest in recent years due to their notable optical and electrochemical properties. Corroles are aromatic tetrapyrrolic macrocycles containing one meso carbon less compared to porphyrins and have one direct pyrrole-pyrrole linkage. This class of macrocycle possesses novel spectral, electrochemical and luminescence properties that can be exploited in material applications. In this book, we have discussed the synthesis, properties and their limited coordination chemistry of expanded porphyrinoid 25-oxasmaragdyrin and core-modified corroles. Corroles, on the other hand, are tetrapyrrolic contracted porphyrins, fully conjugated 18π electron macrocyles containing three methine bridges and one direct pyrrole-pyrrole linkage.

Paperback. The porphyrins are a class of naturally-occurring macrocycles and are ubiquitous in our world. As such, they have been called the Pigments of Life. This auspicious designation reflects their importance in numerous biological functions. Indeed, life as we understand it relies on the full range of biological processes that are either performed by or catalyzed by porphyrin-containing proteins. Chlorophyll-containing photosynthetic reaction centers in plants, for instance, convert light energy into chemical energy while producing oxygen along the way. It is this oxygen, evolved from photosynthesis, that is transported, stored, and reduced by heme-containing proteins in many organisms, including mammals. Not surprisingly, therefore, these molecules remain of fundamental interest to chemists and biochemists. Indeed, they continue to be intensely investigated by researchers world-wide.Inspired by the importance of the porphyrins, a new research di

The Chemistry and Biology of Nitroxyl (HNO) provides first-of-its-kind coverage of the intriguing biologically active molecule called nitroxyl, or azanone per IUPAC nomenclature, which has been traditionally elusive due to its intrinsically high reactivity. This useful resource provides the scientific basis to understand the chemistry, biology, and technical aspects needed to deal with HNO. Building on two decades of nitric oxide and nitroxyl research, the editors and authors have created an indispensable guide for investigators across a wide variety of areas of chemistry (inorganic, organic, organometallic, biochemistry, physical, and analytical); biology (molecular, cellular, physiological, and enzymology); pharmacy; and medicine. This book begins by exploring the unique molecule's structure and reactivity, including important reactions with small molecules, thiols, porphyrins, and key proteins, before discussing chemical and biological sources of nitroxyl. Advanced chapters discuss methods for both trapping and detecting nitroxyl by spectroscopy, electrochemistry, and fluorescent inorganic cellular probing. Expanding on the compound's foundational chemistry, this book then explores its molecular physiology to offer insight into its biological implications, pharmacological effects, and practical issues. - Presents the first book on HNO (nitroxyl or azanone), an increasingly important molecule in biochemistry and pharmaceutical research - Provides a valuable coverage of HNO's chemical structure and significant reactions, including practical guidance on working with this highly reactive molecule - Contains high quality content from recognized experts in both industry and academia

Synthetically useful organic reactions or reagents are often referred to by the name of the discoverer(s) or developer(s). Older name reactions are described in text books, but more recently developed synthetically useful reactions that may have been associated occasionally with a name are not always well known. For neither of the above are experimental procedures or references easy to find. In this monograph approximately 500 name reactions are included, of which over 200 represent newer name reactions and modern reagents. Each of these reactions are extremely useful for the contemporary organic chemistry researcher in industry or academic institutions. This book provides the information in an easily accessible form. In addition to seminal references and reviews, one or more examples for each name reaction are provided and a complete typical experimental procedure is included, to enable the student or researcher to immediately evaluate reaction conditions. Besides an alphabetical listing of reactions and reagents, cross references permit the organic practitioner to find those name reactions or reagents that enable specific transformations, such as, conversion of amines to nitriles, stereoselective reduction, fluoroalkylation, phenol alkynylation, asymmetric syntheses, allylic alkylation, nucleoside synthesis, cyclopentanation, hydrozirconation, to name a few. Emphasis has been placed on stereoselective and regioselective transformations as well as on enantioselective processes. The listing of reactions and reagents is supported by four indexes.

Provides essential information for any chemist or technologist who needs to use or apply organometallic compounds. Provides a comprehensive overview of recent developments in the field and attempts to predict trends in the field over the next ten years.

Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

π-Conjugated molecules with an even number of π-electrons usually have a closed-shell ground state. However, recent studies have demonstrated that a certain type of molecules could show open-shell singlet ground state and display diradical-like (diradicaloid) behavior. Their electronic structure can be understood in terms of the “diradical character” and “aromaticity” concepts. They display very different electronic properties from traditional closed-shell π-conjugated molecules and could be used as next-generation molecular materials. This book provides a comprehensive review on the chemistry, physics, and material applications of open-shell singlet diradicaloids. Particularly, it elaborates the fundamental structure–diradical character–electronic property relationships both theoretically and experimentally. The book has been written by leading scientists in the field from Japan, Germany, Spain, Italy, China, and Singapore.