Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

The first integrated analysis of the causes and effects of diverging views of drug use within the international community.

Analysing arguably one of the most controversial areas in public policy, this pioneering Research Handbook brings together contributions from expert researchers to provide a global overview of the shifting dynamics of drug policy. Emphasising connections between the domestic and the international, contributors illustrate the intersections between drug policy, human rights obligations and the 2030 Sustainable Development Agenda, offering an insightful analysis of the regional dynamics of drug control and the contemporary and emerging problems it is facing.